Search Result

Results for "

antirheumatic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Deaminase (1) Amino Acid Derivatives (2) Antibiotic (6) Apoptosis (6) Autophagy (4) Bacterial (9) c-Fms (1) Calcium Channel (1) Carbonic Anhydrase (1) Caspase (2) Collagen (1) COX (12) Cuproptosis (1) Dihydroorotate Dehydrogenase (3) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) Ferroptosis (4) Fungal (1) HIV (1) IFNAR (1) Interleukin Related (4) Isotope-Labeled Compounds (4) JAK (1) Keap1-Nrf2 (1) Liposome (1) Macrophage migration inhibitory factor (MIF) (2) MMP (1) NF-κB (6) NO Synthase (1) P2X Receptor (1) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (1) PPAR (1) Reactive Oxygen Species (3) Toll-like Receptor (TLR) (1) VEGFR (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (4) Infection (9) Inflammation/Immunology (46) Metabolic Disease (2) Neurological Disease (1)

By Targets:

Adenosine Deaminase (1)

Amino Acid Derivatives (2)

Antibiotic (6)

Apoptosis (6)

Autophagy (4)

Bacterial (9)

c-Fms (1)

Calcium Channel (1)

Carbonic Anhydrase (1)

Caspase (2)

Collagen (1)

COX (12)

Cuproptosis (1)

Dihydroorotate Dehydrogenase (3)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Ferroptosis (4)

Fungal (1)

HIV (1)

IFNAR (1)

Interleukin Related (4)

Isotope-Labeled Compounds (4)

JAK (1)

Keap1-Nrf2 (1)

Liposome (1)

Macrophage migration inhibitory factor (MIF) (2)

MMP (1)

NF-κB (6)

NO Synthase (1)

P2X Receptor (1)

p38 MAPK (1)

Parasite (1)

Phosphodiesterase (PDE) (1)

PPAR (1)

Reactive Oxygen Species (3)

Toll-like Receptor (TLR) (1)

VEGFR (2)

By Research Areas:

Cancer (12)

Cardiovascular Disease (4)

Infection (9)

Inflammation/Immunology (46)

Metabolic Disease (2)

Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W173309

Lonazolac	Drug Intermediate	Inflammation/Immunology
Lonazolac is a non-steroidal antirheumatic agent. Anti-inflammatory effects .

HY-118530

Bucillamine SA96; Thiobutarit	VEGFR	Cardiovascular Disease Inflammation/Immunology
Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an *antirheumatic* agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .

HY-B1245

Salsalate 2 Publications Verification Salicylsalicylic acid; Disalicylic acid	Reactive Oxygen Species	Inflammation/Immunology Cancer
Salsalate is a potent antirheumatic drug with oral activity that reduces irritation during gastric absorption and avoids direct inhibition of cyclooxygenase. Salsalate not only has significant anti-inflammatory effects, but also reduces blood sugar levels, improves insulin resistance, and reduces the expression of cytokines. Salsalate can protect mice from metabolic disorders caused by high-fat diet and effectively improve the symptoms of type 2 diabetes, atherosclerosis and non-alcoholic steatohepatitis ^{[2 ]} .

HY-19440

Esonarimod KE-298	Others	Inflammation/Immunology
Esonarimod (KE-298) is an antirheumatic agent.

HY-14916

Camobucol AGIX 4207	Others	Inflammation/Immunology
Camobucol (AGIX 4207) is an orally active, phenolic antioxidant and anti-inflammatory compound with antirheumatic properties.

HY-B0083

Leflunomide 5+ Cited Publications HWA486; RS-34821; SU101	Dihydroorotate Dehydrogenase Endogenous Metabolite Bacterial	Cancer
Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.

HY-129761

AR 17048	Others	Inflammation/Immunology
AR 17048 is a potent antirheumatic agent .

HY-106325

AA 2379	Phosphodiesterase (PDE)	Inflammation/Immunology
AA 2379 is an orally active antirheumatic agent. AA 2379 has antiinflammatory, antipyretic activities and reduces pain sensation .

HY-118530R

Bucillamine (Standard)	VEGFR	Cardiovascular Disease Inflammation/Immunology
Bucillamine (Standard) is the analytical standard of Bucillamine. This product is intended for research and analytical applications. Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an *antirheumatic* agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .

HY-137149

Lonazolac hemicalcium	COX	Inflammation/Immunology
Lonazolac (hemicalcium) is the calcium salt form of Lonazolac. Lonazolac is a nonsteroidal antirheumatic agent with anti-inflammatory properties .

HY-101716

RP-54745 1 Publications Verification	Interleukin Related	Inflammation/Immunology
RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.

HY-76938

Actarit 4-Acetylaminophenylacetic acid; MS-932	Liposome Carbonic Anhydrase	Inflammation/Immunology
Actarit, an orally active antirheumatic compound, has the potential to treat type II collagen-induced arthritis .

HY-13075

c-Fms-IN-3 1 Publications Verification	c-Fms	Inflammation/Immunology
c-Fms-IN-3 is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent.

HY-N8251

Cyclocurcumin	p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Cyclocurcumin is a potent p38α inhibitor. Cyclocurcumin shows antirheumatic, antivasoconstrictive and antioxidant activities .

HY-B0300S

Penicillamine-d3 D-(-)-Penicillamine-d₃	Drug Metabolite Isotope-Labeled Compounds Cuproptosis	Inflammation/Immunology
Penicillamine-d₃ is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.

HY-B0083R

Leflunomide (Standard)	Dihydroorotate Dehydrogenase Endogenous Metabolite Bacterial	Cancer
Leflunomide (Standard) is the analytical standard of Leflunomide. This product is intended for research and analytical applications. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.

HY-122154

FR234938	Adenosine Deaminase	Inflammation/Immunology
FR234938 is a non-nucleoside adenosine deaminase inhibitor with an IC₅₀ of 17 nM for recombinant human adenosine deaminase enzyme. FR234938 has anti-rheumatic and anti-inflammatory effects .

HY-127150

Clofezone Perclusone	Collagen	Inflammation/Immunology
Clofezone (Perclusone) is an antirheumatic agent that inhibits collagen formation in rat Chondrus granulomas. Clofezone can be used in the study of various rheumatic diseases, especially arthritis (RA) and ankylosing spondylitis (AS) .

HY-151241

Sinomenine N-oxide (+)-Sinomenine N-oxide	NO Synthase	Inflammation/Immunology
Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC₅₀ value of 23.04 μM .

HY-14655

Sulfasalazine Maximum Cited Publications 43 Publications Verification NSC 667219	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-120049

TAK-603	Interleukin Related IFNAR	Inflammation/Immunology
TAK-603 is a potent and orally active antirheumatic agent. TAK-603 inhibits Thl-type cytokine production. TAK-603 has the potential for the research of adjuvant arthritis .

HY-106027

Romazarit RO 31-3948	PPAR	Metabolic Disease Inflammation/Immunology
Romazarit (RO 31-3948) is an anti-inflammatory agent with antirheumatic effect. Romazarit exhibits PPARα agonist activity. Romazarit (30 mg/kg) inhibits the development of hindpaw inflammation in an adjuvant arthritis model .

HY-17490

Oxaceprol 1 Publications Verification N-Acetyl-L-hydroxyproline	Amino Acid Derivatives	Inflammation/Immunology
Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .

HY-169306

IL-17A inhibitor 4	Interleukin Related	Inflammation/Immunology
IL-17A inhibitor 4 (Example 449) is a potent IL-17A inhibitor. IL-17A inhibitor 4 inhibits HTRF and NHK cells viability with IC₅₀s of 0.028 and 0.0047 μM, respectively .

HY-17490R

Oxaceprol (Standard)	Amino Acid Derivatives	Inflammation/Immunology
Oxaceprol (Standard) is the analytical standard of Oxaceprol. This product is intended for research and analytical applications. Oxaceprol (N-Acetyl-L-hydroxyproline), an orally active derivative of L-proline, possesses distinct anti-inflammatory activity. Oxaceprol is usually used for the research of osteoarthritis and rheumatoid arthritis .

HY-B0083S

Leflunomide-d4	Dihydroorotate Dehydrogenase	Cancer
Leflunomide-d₄ (HWA486-d4) is the deuterium labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent[1][2].

HY-17361

Etofenamate	COX	Inflammation/Immunology
Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-B0212

Sulfapyridine	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits *recombinant P. carinii* dihydropteroate synthetase (DHPS) with an IC₅₀** of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-17009

Iguratimod 5 Publications Verification T614	Macrophage migration inhibitory factor (MIF) COX	Inflammation/Immunology
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC₅₀ of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC₅₀ of 6.81 μM.

HY-A0068

Aurothioglucose 1 Publications Verification Gold thioglucose	NF-κB HIV Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC₅₀ of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities .

HY-14750

Rabeximod ROB-803	Toll-like Receptor (TLR)	Neurological Disease Inflammation/Immunology
Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. Rabeximod (ROB-803) is used for rheumatoid arthritis (RA) research .

HY-14655S

Sulfasalazine-d4	Isotope-Labeled Compounds NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Sulfasalazine-d₄ is the deuterium labeled Sulfasalazine. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[1][2][3][4].

HY-14655R

Sulfasalazine (Standard)	NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Sulfasalazine (Standard) is the analytical standard of Sulfasalazine. This product is intended for research and analytical applications. Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-145455

Salazopyridazine	Bacterial	Infection
Salazopyridazine is an antibacterial agent. Salazopyridazine shows activities against ulcerative colitis. Salazopyridazine can be used for the research of rheumatic diseases .

HY-17361S

Etofenamate-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Etofenamate-d₄ is the deuterium labeled Etofenamate. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases[1][2][3].

HY-14655S1

Sulfasalazine-d3,15N NSC 667219-d₃,¹⁵N	Antibiotic Autophagy NF-κB Apoptosis Bacterial Ferroptosis Isotope-Labeled Compounds	Infection Inflammation/Immunology Cancer
Sulfasalazine-d₃, ¹⁵N is ¹⁵N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

HY-B0212R

Sulfapyridine (Standard)	Bacterial Antibiotic	Infection Inflammation/Immunology
Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits *recombinant P. carinii* dihydropteroate synthetase (DHPS) with an IC₅₀** of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities .

HY-17009R

Iguratimod (Standard)	Macrophage migration inhibitory factor (MIF) COX	Inflammation/Immunology
Iguratimod (Standard) is the analytical standard of Iguratimod. This product is intended for research and analytical applications. Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC₅₀ of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC₅₀ of 6.81 μM.

HY-17361R

Etofenamate (Standard)	COX	Inflammation/Immunology
Etofenamate (Standard) is the analytical standard of Etofenamate. This product is intended for research and analytical applications. Etofenamate, a non-steroid anti-inflammatory agent (NSAID) and a non-selective COX inhibitor, possesses analgesic, anti-rheumatic, antipyretic and anti-inflammatory properties. Etofenamate is used in the research for osteoarthritis, arthritis and other inflammatory diseases .

HY-N5025

Bullatine A	P2X Receptor Apoptosis	Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed .

HY-105028

Tenidap CP-66248	COX	Inflammation/Immunology
Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC₅₀ values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties . Tenidap is also a specific SLC26A3 inhibitor .

HY-105028A

Tenidap sodium CP-66248 sodium	COX	Inflammation/Immunology
Tenidap is a non-steroidal anti-inflammatory active molecule and a selective inhibitor of COX-1, with IC₅₀ values of 0.03 μM for COX-1 and 1.2 μM for COX-2. Tenidap exhibits anti-inflammatory and anti-rheumatic effects. Tenidap is a specific inhibitor of SLC26A3 .

HY-B1245R

Salsalate (Standard) Salicylsalicylic acid (Standard); Disalicylic acid (Standard)	Reactive Oxygen Species	Inflammation/Immunology
Salsalate (Standard) is the analytical standard of Salsalate. This product is intended for research and analytical applications. Salsalate, a non-acetylated salicylate, is an effective antirheumatic agent that bypasses gastric absorption and also avoids cyclooxygenase inhibition. Salsalate has anti-inflammatory activity and reduces glucose levels, insulin resistance, and cytokine expression. Salsalate can be used in the research of type 2 diabetes .

HY-N0283

Diacerein 3 Publications Verification Diacerhein; Diacetylrhein	Interleukin Related Calcium Channel	Inflammation/Immunology
Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research .

HY-B1138

Fenbufen 1 Publications Verification CL-82204	COX Caspase	Inflammation/Immunology
Fenbufen (CL-82204) is an orally active *non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1* and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-B1138R

Fenbufen (Standard)	COX Caspase	Inflammation/Immunology
Fenbufen (Standard) is the analytical standard of Fenbufen. This product is intended for research and analytical applications. Fenbufen (CL-82204) is an orally active *non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1* and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-114275

Justicidin B	Fungal Parasite Apoptosis	Infection Cardiovascular Disease Cancer
Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation .

HY-105028S

Tenidap-d3 CP-66248-d₃	COX	Inflammation/Immunology
Tenidap-d₃ is the deuterium labeled Tenidap. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor[3].

HY-105028R

Tenidap (Standard)	COX	Inflammation/Immunology
Tenidap (Standard) is the analytical standard of Tenidap. This product is intended for research and analytical applications. Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC₅₀ values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties . Tenidap is also a specific SLC26A3 inhibitor .

HY-N0807

Swertiamarin	MMP NF-κB JAK Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .

Cat. No.	Product Name

HY-L210

Anti-Rheumatic Arthritis Compound Library

1,483 compounds

Rheumatoid Arthritis (RA) is a autoimmune disease characterized by persistent joint inflammation. The pathology of RA includes immune cell infiltration, synovial lining proliferation, pannus formation, and the destruction of joint cartilage and bone, which is highly disabling. Due to long-term chronic inflammation, RA not only severely affects the quality of life of patients but can also damage multiple organs, leading to lung diseases, cardiovascular diseases, and malignant tumors. The pathogenesis of RA is complex, involving genetic, environmental, and immune factors. With the advancement of high-throughput screening technology, screening for compounds targeting JAK, CCR, MEK, MMP targets may contribute to the development of more effective drugs against Rheumatoid Arthritis (RA).

MCE has collected 1,483 small molecule compounds with definite or potential anti-rheumatoid arthritis activity. This library is of significant value for researching the anti-RA drugs.

Cat. No.	Product Name	Target	Research Area