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Results for "

antitubercular activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (2) Bacterial (43) DNA/RNA Synthesis (2) Endogenous Metabolite (1) Fungal (4) MDM-2/p53 (1) p38 MAPK (1) Parasite (3)
By Research Areas:	Cancer (5) Infection (42) Inflammation/Immunology (5) Metabolic Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-143232

Antibacterial agent 73	Fungal Bacterial	Infection Cancer
Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC₅₀ of 8.20 μM .

HY-132928

Antitubercular agent-10	Bacterial	Infection
Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

HY-162684

Antitubercular agent-46	Bacterial	Infection Inflammation/Immunology
Antitubercular agent-46 (4B) is an anti-tubercular agent, with a MIC of 7.81 μg/ mL. Antitubercular agent-46 (4B) possesses antioxidant activity .

HY-132910

Antitubercular agent-9	Bacterial	Infection
Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM.

HY-149857

Antitubercular agent-37	Bacterial	Infection
Antitubercular agent-37 is an antibacterial agent. Antitubercular agent-37 has antimycobacterial activity with an MIC values of 0.16 μg/mL. Antitubercular agent-37 can be used for the research of tuberculosis .

HY-163033

Antitubercular agent-42	Bacterial	Infection
Antitubercular agent-42(19) is a selective fatty acyl-AMP ligase (FAAL) inhibitor (MIC₉₀ = 1.4 µg/mL for M. tuberculosis H37Rv). Antitubercular agent-42 shows antitubercular activity .

HY-147884

Antitubercular agent-28	Bacterial	Infection
Antitubercular agent-28 (compound 2) is a potent *antitubercular* agent with an IC₅₀ value of 1.5 µM, an MIC value of 4.5 µM, an IC₉₀ value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity .

HY-147883

Antitubercular agent-27	Bacterial	Infection
Antitubercular agent-27 (compound 1) is a potent *antitubercular* agent with an IC₅₀ value of 3.2 µM, an MIC value of 7.8 µM, an IC₉₀ value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity .

HY-146496

Antitubercular agent-20	Bacterial	Infection
Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .

HY-147505

Antitubercular agent-21	Bacterial Fungal	Infection
Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H₃₇R_v. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity .

HY-146495

Antitubercular agent-19	Bacterial	Infection
Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .

HY-156021

Antitubercular agent-40	Bacterial	Infection
Antitubercular agent-40 (compound 93) is a thieno[2,3-b]quinoline-2-carboxamide compound with potential antitubercular activity .

HY-155067

Antitubercular agent-38	Bacterial	Infection
Antitubercular agent-38 is an orally active Benzothiazinones (BTZs) derivate, with potent antituberculosis activity. Antitubercular agent-38 exhibits low cardiac toxicity, low cell cytotoxicity .

HY-162094

Antitubercular agent-44	Bacterial	Infection
Antitubercular agent-44 (compound 21b) has anti-tuberculosis (H37Rv MIC = 0.06 μM). Antitubercular agent-44 has oral activity .

HY-129943

Benzothiohydrazide	Bacterial	Infection
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC₁ and IC₂) .

HY-N12276

(±)-Emodin bianthrone	Parasite Bacterial Fungal	Infection
(±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .

HY-156361

Tuberculosis inhibitor 11	Bacterial	Infection
Tuberculosis inhibitor 11 (Compound 14) can sensitize the antimycobacterial activity of the antitubercular agent .

HY-119369

FadD32 Inhibitor-1	Bacterial	Infection
FadD32 Inhibitor-1 is a potent FadD32 inhibitor with anti-tubercular activity .

HY-117837

GSK1829820A	Antibiotic Bacterial	Infection
GSK1829820A has antitubercular activity which can inhibit Mycobacterium tuberculosis H37Rv .

HY-120555

Texaline	Bacterial	Infection
Texaline is a active product that can be isolated from Amyris species of plants in the Caribbean. Texaline has antitubercular activity .

HY-19750

TBA-7371 1 Publications Verification	Bacterial	Infection
TBA-7371 is a potent, noncovalent DprE1 inhibitor. TBA-7371 has potent antitubercular activity .

HY-W005327

1-Hydroxy-2-butanone	Bacterial Endogenous Metabolite	Infection Inflammation/Immunology
1-Hydroxy-2-butanone is a natural compound isolated from Bomboo Juice with antitubercular activity .

HY-156421

QST4	Bacterial	Infection
QST4 has antitubercular activity, with the MIC value of 6.25 μM in Mycobacterium tuberculosis H37Rv .

HY-124301

Penicolinate A	Bacterial	Infection
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

HY-148111

Antitubercular agent-33	Bacterial	Infection
Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

HY-117990

GSK572A	Bacterial	Infection
GSK572A is a potent EchA6 inhibitor with an K_d value of 1.9 µM. GSK572A shows anti-tubercular activity .

HY-123451

ACH-702	Bacterial	Infection
ACH-702 is a potent anti-tubercular agent. ACH-702 also shows broad-spectrum antibacterial activity .

HY-146051

Antitubercular agent-18	Bacterial	Infection
Antitubercular agent-18 (Compound 9a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-18 shows highly selective antimycobacterial effects .

HY-146050

Antitubercular agent-17	Bacterial	Infection
Antitubercular agent-17 (Compound 8a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-17 shows highly selective antimycobacterial effects .

HY-N0804

Narirutin 2 Publications Verification	Bacterial	Inflammation/Immunology
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-155332

AB131	Bacterial	Infection
AB131 is a MSMEG 6649 and Rv2172c inhibitor (K_d: 0.16 and 0.02 μM respectively). AB131 can sensitize the antimycobacterial activity of the antitubercular agent .

HY-160922

BAY 249716	MDM-2/p53 Bacterial	Infection Cancer
BAY 249716 stabilizes all three p53 protein variants. BAY 249716 also has antitubercular activity (IC₉₀: <0.10 μg/mL for Tuberculosis) .

HY-139424

SQ609	Bacterial	Cancer
SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .

HY-147819

DNA Gyrase-IN-3	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-3 (Compound 28) is a bacterial DNA gyrase B inhibitor with IC₅₀s of 5.41-15.64 µM for E. coli DNA gyrase. Anti-tubercular and antibacterial activity .

HY-124781

ML406	Bacterial Antibiotic	Infection
ML406 is a small molecule probe that shows *anti-tubercular* activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC₅₀ of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .

HY-N0804R

Narirutin (Standard)	Bacterial	Inflammation/Immunology
Narirutin (Standard) is the analytical standard of Narirutin. This product is intended for research and analytical applications. Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-N2208

4-Hydroxylonchocarpin 1 Publications Verification	p38 MAPK	Infection Metabolic Disease Inflammation/Immunology Cancer
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities .

HY-146374

Antibacterial agent 96	Bacterial	Infection
Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells .

HY-147818

DNA Gyrase-IN-2	Bacterial DNA/RNA Synthesis	Infection
DNA Gyrase-IN-2 (Compound 22a) is a bacterial DNA gyrase B inhibitor with IC₅₀s of 3.29-10.49 and 4.41-5.61 µM for E. coli DNA gyrase and M. tuberculosis DNA gyrase. Anti-tubercular and antibacterial activity .

HY-152138

Antituberculosis agent-8	Bacterial Fungal	Infection
Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against *M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal* activity against A. niger with an MIC of 62.50 μM .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Bacterial	Infection
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-151340

Antitubercular agent-32	Bacterial	Infection
Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC₅₀=3.9 μM) .

HY-126640

Phomoxanthone A	Parasite	Infection Cancer
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-14988

I-A09	Bacterial	Infection
I-A09 and its derivatives, specifically 1,2,3-triazole-adamantylacetamide hybrids (5a–u), exhibit significant antitubercular activity. These hybrids were synthesized using copper-catalyzed click chemistry, combining bioactive fragments from antitubercular I-A09 and substituted adamantyl urea. The compound N-(1-adamantyl)-2-azido acetamide was reacted with various alkyl/aryl acetylenes to produce new analogues. Among them, N-(1-adamantan-1-yl)-2-(4-(phenanthren-2-yl)-1H-1,2,3-triazol-1-yl)acetamide (5t) showed the most promise with a minimum inhibitory concentration (MIC) of 3.12 μg/mL against Mycobacterium tuberculosis H37Rv, and a selectivity index greater than 15 .

HY-155846

Antileishmanial agent-22	Parasite Bacterial	Infection
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC₅₀=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC₅₀), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM .

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antitubercular activity

Inhibitors & Agonists

NaturalProducts

Natural
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