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antituberculosis activity

" in MedChemExpress (MCE) Product Catalog:

57

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Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151514
    Antituberculosis agent-5

    		Bacterial Infection
    Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC50 value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .
    Antituberculosis agent-5
  • HY-168946
    InhA-IN-9

    		Bacterial Infection
    InhA-IN-9 (compound 7h) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor. InhA-IN-9 could bind to InhA. InhA-IN-9 shows a antituberculosis activity at MIC value of 2 μg/mL .
    InhA-IN-9
  • HY-152136
    Antituberculosis agent-6

    		Bacterial Fungal Infection
    Antituberculosis agent-6 (compound 9g) is a potent antimycobacterial agent. Antituberculosis agent-6 shows significant activity against M. tuberculosis, with a MIC of 3.49 μM. Antituberculosis agent-6 also shows good antifungal activity against A. niger, with a MIC of 62.50 μM. Antituberculosis agent-6 shows high GI absorption .
    Antituberculosis agent-6
  • HY-151205
    Antituberculosis agent-3

    		Bacterial Infection Inflammation/Immunology
    Antituberculosis agent-3 (Compound 2) is an antituberculosis agent. Antituberculosis agent-3 shows anti-mycobacterial activity, and can inhibit M. tuberculosis H37Rv strain growth (MIC=12.5 μg/mL) .
    Antituberculosis agent-3
  • HY-146057
    Antituberculosis agent-2

    		Bacterial Infection
    Antituberculosis agent-2 (Compound 8d) is an antituberculosis agent against agent-sensitive and multidrug-resistant tuberculosis. Antituberculosis agent-2 shows anti-tuberculosis activity with MIC values of 0.454, 1.757 and 1.644 μg/mL against M. tuberculosis H37Rv, 13946 and 14862, respectively. Antituberculosis agent-2 displays favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability .
    Antituberculosis agent-2
  • HY-W716673
    Ftivazide

    Phthivazide

    		 Bacterial Infection
    Ftivazide has anti-tuberculosis activity .
    Ftivazide
  • HY-152137
    Antituberculosis agent-7

    		Bacterial Fungal Antibiotic Infection Inflammation/Immunology
    Antituberculosis agent-7, an oxetanyl-quinoline derivative, has shown good antibacterial activity against P. mirabilis with a MIC of 31.25 μM. Antituberculosis agent-7 shows good antifungal activity against A. niger with a MIC of 62.5 μM. Antituberculosis agent-7 shows excellent antimycobacterial activity with MIC 3.41 μM for M. tuberculosis H37Rv .
    Antituberculosis agent-7
  • HY-163486
    Antituberculosis agent-10

    		Bacterial Infection
    Antituberculosis agent-10 (Compound 9) has excellent antibacterial activity against Mycobacterium tuberculosis (MIC = 0.3 μM). Antituberculosis agent-10 inhibits protein synthesis by targeting the 50S ribosomal subunit of the bacterium, thus exerting its antibacterial effect. Antituberculosis agent-10 is orally active .
    Antituberculosis agent-10
  • HY-113834
    (R,R)-Ethambutol

    		Bacterial Infection
    (R,R)-Ethambutol is an antituberculosis compound with tuberculosis inhibitory activity. (R,R)-Ethambutol is often used in combination with other antituberculosis compounds to enhance the efficacy. (R,R)-Ethambutol can also be used to inhibit Mycobacterium avium complex infection and Mycobacterium kansasii infection .
    (R,R)-Ethambutol
  • HY-168860
    Antituberculosis agent-13

    		Bacterial Infection Cancer
    Antituberculosis agent-13 (Compound 11) inhibits Mycobacterium tuberculosis, that inhibits Mtb wildtype and mutated strains with IC50 of 4-62.5 nM. Antituberculosis agent-13 exhibits anti-leukemia activity that inhibits MOLM-13 with IC50 of 3.8 μM .
    Antituberculosis agent-13
  • HY-W129661
    Pyrazine-2-carbothioamide

    		Bacterial Infection
    Pyrazine-2-carbothioamide is an effective antituberculosis agent with inhibitory activity against mycobacterium in vitro .
    Pyrazine-2-carbothioamide
  • HY-152138
    Antituberculosis agent-8

    		Bacterial Fungal Infection
    Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal activity against A. niger with an MIC of 62.50 μM .
    Antituberculosis agent-8
  • HY-W716673R
    Ftivazide (Standard)

    		Bacterial Infection
    Ftivazide (Standard) is the analytical standard of Ftivazide. This product is intended for research and analytical applications. Ftivazide has anti-tuberculosis activity .
    Ftivazide (Standard)
  • HY-113095R
    γ-CEHC (Standard)

    		Drug Metabolite Endogenous Metabolite Others
    Ftivazide (Standard) is the analytical standard of Ftivazide. This product is intended for research and analytical applications. Ftivazide has anti-tuberculosis activity .
    γ-CEHC (Standard)
  • HY-B0276
    Ethionamide
    1 Publications Verification

    2-Ethylthioisonicotinamide

    		 Bacterial Antibiotic Infection
    Ethionamide (2-ethylthioisonicotinamide) is a second-line anti-tuberculosis antibiotic with antibacterial effect and oral activity .
    Ethionamide
  • HY-148478
    MMV688845

    (R)-GSK1729177A

    		 DNA/RNA Synthesis Infection
    MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .
    MMV688845
  • HY-125576
    Griselimycin

    		Bacterial Others
    Griselimycin is a compound with antituberculosis activity that exhibits good in vitro and in vivo activity against sensitive and resistant Mycobacterium tuberculosis, and its cyclohexyl derivative has high transformative potential.
    Griselimycin
  • HY-12485
    TBA-354

    		Bacterial Antibiotic Infection
    TBA-354 is a potent anti-tuberculosis compound; maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains.
    TBA-354
  • HY-139863
    Antibacterial agent 62

    		Bacterial Infection
    Antibacterial agent 62 is a novel redox cycling antituberculosis chemotype with potent bactericidal activity against growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria.
    Antibacterial agent 62
  • HY-117126
    BTZ-N3

    		Bacterial Infection
    BTZ-N3 is a potent reversible and noncovalent inhibitor of decaprenylphosphoryl-β-d-ribose 2′ oxidase (DprE1) that shows anti-tuberculosis activity .
    BTZ-N3
  • HY-Y0030
    3-Hydroxypicolinic acid

    3-hydroxypyridine-2-carboxylic acid

    		 Endogenous Metabolite Infection
    3-Hydroxypicolinic acid is a picolinic acid derivative, and belongs to the pyridine family. 3-hydroxypicolinic acid can be used to synthesize copper(II) complexes with anti-tuberculosis activity .
    3-Hydroxypicolinic acid
  • HY-126597
    Chaetoglobosin C

    		Bacterial Infection
    Chaetoglobosin C (Compound 4) is a anthraquinone-chromone compound derived from the fungus Chaetomium globosum KMITL-N0802. Chaetoglobosin C has anti-tuberculosis activity .
    Chaetoglobosin C
  • HY-122448A
    (Rac)-Sativan

    		Bacterial Fungal Infection
    (Rac)-Sativan is an isoflavanoid with a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi. (Rac)-Sativan exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 µg/mL .
    (Rac)-Sativan
  • HY-155067
    Antitubercular agent-38

    		Bacterial Infection
    Antitubercular agent-38 is an orally active Benzothiazinones (BTZs) derivate, with potent antituberculosis activity. Antitubercular agent-38 exhibits low cardiac toxicity, low cell cytotoxicity .
    Antitubercular agent-38
  • HY-162028
    GaMF1.39

    		Bacterial Infection
    GaMF1.39 is an antimycobacterial compound, targeting the F-ATP synthase subunit γ. GaMF1.39 displays enhanced anti-tuberculosis activity in combination with ETC inhibitors .
    GaMF1.39
  • HY-162094
    Antitubercular agent-44

    		Bacterial Infection
    Antitubercular agent-44 (compound 21b) has anti-tuberculosis (H37Rv MIC = 0.06 μM). Antitubercular agent-44 has oral activity .
    Antitubercular agent-44
  • HY-119166
    3,5,4'-Tribromosalicylanilide

    		Bacterial Others
    3,5,4'-Tribromosalicylanilide is a compound with antituberculosis and anti-Mycobacterium abscessus activities, which was found to inhibit the growth of Mycobacterium tuberculosis and Mycobacterium abscessus and affect gene expression by computational compound repositioning approach.
    3,5,4'-Tribromosalicylanilide
  • HY-134940
    Quabodepistat
    2 Publications Verification

    OPC-167832

    		 Bacterial Infection Inflammation/Immunology
    Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with an IC50 of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis .
    Quabodepistat
  • HY-151956
    Mtb-cyt-bd oxidase-IN-7

    		Bacterial Infection
    Mtb-cyt-bd oxidase-IN-7 is a cytochrome bd terminal oxidase (Cyt-bd) inhibitor with a Kd value of 4.17 μM. Mtb-cyt-bd oxidase-IN-7 shows anti-tuberculosis activities .
    Mtb-cyt-bd oxidase-IN-7
  • HY-169108
    DprE1-IN-11

    		Bacterial Infection
    DprE1-IN-11 (compound 3) is an orally active DprE1 inhibitor with antituberculosis activity against MTB H37Rv and MDR-MTB strains (MIC <0.029-0.095 μM) .
    DprE1-IN-11
  • HY-N13197
    5,6-Dihydro-6-methyl-2H-pyran-2-one

    		Antibiotic Bacterial Fungal Parasite Infection Inflammation/Immunology Cancer
    5,6-Dihydro-6-methyl-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities .
    5,6-Dihydro-6-methyl-2H-pyran-2-one
  • HY-116943
    MTC420

    		Bacterial Infection
    MTC420 (compound 42a) is a heterocyclic quinolone compound that targets the respiratory chain of Mycobacterium tuberculosis and exhibits antituberculosis activity (Rep Mtb: IC50=525 nM, Wayne Mtb: IC50=76 nM, MDR Mtb: IC50=140 nM) .
    MTC420
  • HY-114604
    Propioxatin B

    		Bacterial Others
    Propioxatin B is a tricyclic sesquiterpenoid compound isolated from the root of vetiver grass. It has anti-tuberculosis activity and inhibitory effects on a variety of drug-resistant mutants of Mycobacterium tuberculosis. In computer simulation docking studies, it showed binding affinity with bacterial DNA gyrase and has a certain safety in vivo.
    Propioxatin B
  • HY-162527
    Antibacterial agent 216

    		Bacterial Infection
    Antibacterial agent 216 (Compound 2a) is an antibacterial agent that exhibits significant bactericidal effects when combined with INH and RIF. Antibacterial agent 216 has demonstrated remarkable in vitro anti-tuberculosis activity against Mtb H37Rv and MDR clinical isolates and can be used for tuberculosis research .
    Antibacterial agent 216
  • HY-150967
    MmpL3-IN-1

    		Bacterial Infection
    MmpL3-IN-1 (compound 32) is a potent Mycobacterial membrane protein large 3 (MmpL3) inhibitor. MmpL3-IN-1 has anti-tuberculosis activity with the MIC<0.016 μg/mL in M. tuberculosis and can be used in studies of drug-resistant tuberculosis .
    MmpL3-IN-1
  • HY-117145
    Thiophene-2

    		Bacterial Infection
    Thiophene-2 (TP2) is a specific polyketide synthase 13 (Pks13) inhibitor. Thiophene-2 inhibits mycolic acid biosynthesis and rapidly leads to mycobacterial cell death. Thiophene-2 is active against Mycobacterium tuberculosis with a MIC value of 1 μM, and has potent anti-tuberculosis activity .
    Thiophene-2
  • HY-N1887
    4-Allylcatechol
    1 Publications Verification

    Hydroxychavicol; 4-Allylpyrocatechol

    		 Bacterial Antibiotic TNF Receptor Interleukin Related Infection Cardiovascular Disease Neurological Disease Cancer
    4-Allylcatechol (4-Allylpyrocatechol) is a xylan which has oral activity and can be isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC50 = 5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC = 27.6 μg/mL) .
    4-Allylcatechol
  • HY-129819
    (Rac)-DNDI-8219

    		Bacterial Infection
    (Rac)-DNDI-8219 is an antituberculosis compound with potent anti-leishmanial activity. (Rac)-DNDI-8219 demonstrated superior efficacy in the Leishmania donovani mouse model. (Rac)-DNDI-8219 showed promising activity in the Leishmania infantum hamster model. (Rac)-DNDI-8219 candidate compound R-6 provided excellent oral efficacy in the same hamster model .
    (Rac)-DNDI-8219
  • HY-146158
    Fudapirine

    WX-081

    		 Bacterial Potassium Channel Antibiotic Infection
    Fudapirine, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. Fudapirine exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. Fudapirine also inhibits hERG channel with the IC50 of 1.89 μM.
    Fudapirine
  • HY-159565
    VEGFR-2/InhA-IN-1

    		Bacterial VEGFR Infection
    VEGFR-2/InhA-IN-1 is a pyrazole-based dual inhibitor of InhA-VEGFR with anti-tuberculosis and anti-angiogenic activities. VEGFR-2/InhA-IN-1 has good antibacterial activity against Mycobacterium tuberculosis H37Rv strain (MIC=6.25 μg/mL) and significantly inhibits VEGFR-2 (IC50=15.27 nM) .
    VEGFR-2/InhA-IN-1
  • HY-N12232
    Carbazomycin D

    		Parasite Bacterial Infection Cancer
    Carbazomycin D exhibits antituberculosis and antimalarial activities, that inhibits Plasmodium falciparum with an IC50 > 10 μg/mL, inhibits Mycobacterium tuberculosis with MIC of 25 μg/mL. Carbazomycin D exhibits cytotoxicity in cell MCF-7, KB, NCI-H187 and Vero, with IC50s of 21.3, 33.2, 12.9, and 34.3 μg/mL, respectively .
    Carbazomycin D
  • HY-B0276A
    Ethionamide hydrochloride

    2-Ethylthioisonicotinamide hydrochloride

    		 Bacterial Infection
    Ethionamide hydrochloride (2-Ethylthioisonicotinamide hydrochloride) is an antituberculosis drug with mycobacterial activity. Ethionamide hydrochloride interferes with the bacterial cell wall synthesis process by inhibiting the synthesis of fatty acids in the bacterial cell wall. Ethionamide hydrochloride may have bacteriostatic or bactericidal effects, depending on the concentration of the drug at the site of infection and the susceptibility of the associated microorganisms. Ethionamide hydrochloride combines with NAD+ to form an adduct, thereby exerting its antibacterial effect .
    Ethionamide hydrochloride
  • HY-158380
    UH-NIP-16

    		Bacterial Infection
    UH-NIP-16 exhibits antimicrobial activity against Mycobacterium tuberculosis, with MIC50 of 1.86 and 3.05 μM, for pathogenic mycobacterial strains H37Rv and CDC1551. UH-NIP-16 synergizes with Streptomycin (HY-B1906), Isoniazid (HY-B0329), Ethambutol (HY-B0535) and Bedaquiline (HY-14881), potentiates their anti-tuberculosis activities .
    UH-NIP-16
  • HY-155558
    MptpB-IN-2

    		Antibiotic Infection
    MptpB-IN-2 (compound 20) is a selective mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with IC50s of 0.64 μM, 4.06 μM and 4.14 μM for MptpB, MptpA and PTP1B, respectively. MptpB-IN-2 shows weak antituberculosis activity with a MIC of 64.9 μM for Mtb H37Rv .
    MptpB-IN-2
  • HY-138958
    HT1171

    		Bacterial Virus Protease Infection
    HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent .
    HT1171
  • HY-162508
    KSK-104

    		Bacterial Infection
    KSK-104 has potent antibacterial activity against Mycobacterium tuberculosis (MIC=0.78 μM). The role of KSK-104 is mainly involved in the synthesis and recovery pathways of pyridoxal 5'-phosphate (PLP), PLP-dependent enzymes and oxidative stress networks. KSK-104, as a candidate molecule for novel anti-tuberculosis drugs, can be used to develop research against drug-resistant mycobacterium tuberculosis .
    KSK-104
  • HY-162521
    Antibacterial agent 215

    		Bacterial Fungal Infection
    Antibacterial agent 215 (Compound 3b) is an inhibitor for carbonic anhydrase (CA), with Ki of 17.61, 5.14 and 43.74 nM, for hCA I, hCA II and AChE, respectively. Antibacterial agent 215 exhibits anti-tuberculosis, with MIC of 62.5 µg/ml against M. tuberculosis. Antibacterial agent 215 exhibits antifungal activities against Candida spp. strains ATCC 14053, ATCC 1369, and ATCC 15126, with MICs of 125 µg/ml .
    Antibacterial agent 215
  • HY-14743B
    Golotimod hydrochloride

    SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride

    		 Bacterial STAT Infection Inflammation/Immunology Cancer
    Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
    Golotimod hydrochloride
  • HY-145286
    IMPDH2-IN-2

    		Bacterial Infection Cancer
    IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent .
    IMPDH2-IN-2
  • HY-14743
    Golotimod

    SCV 07; Gamma-D-glutamyl-L-tryptophan

    		 Bacterial STAT Infection Inflammation/Immunology Cancer
    Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
    Golotimod

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