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Results for "

arthritic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) Bombesin Receptor (2) Carbonic Anhydrase (1) CXCR (2) DNA/RNA Synthesis (1) ERK (2) Fungal (2) HDAC (1) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (1) JAK (2) Lipoxygenase (1) mGluR (1) NF-κB (4) p38 MAPK (3) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (1) STAT (2) TNF Receptor (1) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (29) Metabolic Disease (3) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2513

β-Boswellic acid	Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-107360

Lobenzarit disodium CCA	Reactive Oxygen Species	Inflammation/Immunology Cancer
Lobenzarit disodium (CCA) is an anti-arthritic and anti-oxidative agent .

HY-W015600

2-Acetamidophenol Orthocetamol	Others	Inflammation/Immunology
Paracetamol (4-acetamidophenol). 2-Acetamidophenol is a promising analgesic and an anti-arthritic agent .

HY-N5010

Nepitrin Nepetin-7-glucoside	Others	Inflammation/Immunology
Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-N6647

Luteolin-7-rutinoside	Fungal	Infection Inflammation/Immunology
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

HY-107510

YM-230888	mGluR	Neurological Disease
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a K_i of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC₅₀ of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models .

HY-100142

Clozic ICI 55897; Clobuzarit	Others	Inflammation/Immunology
Clozic is a potential anti-arthritic agent.

HY-136540

Resolvin D3 RvD3	Others	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-120529

Aciculatin	Others	Others
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

HY-P0107

RC-3095	Bombesin Receptor	Inflammation/Immunology
RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-120677

AHR-15010	Carbonic Anhydrase	Inflammation/Immunology
AHR-15010 is an oral active carbonic anhydrase inhibitor with the IC₅₀ of 0.13 μM. AHR-15010 shows anti-arthritic activity and can be used for study of arthritis .

HY-N5010R

Nepitrin (Standard)	Others	Inflammation/Immunology
Nepitrin (Standard) is the analytical standard of Nepitrin. This product is intended for research and analytical applications. Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-P0107A

RC-3095 TFA 1 Publications Verification	Bombesin Receptor	Inflammation/Immunology
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-W015600R

2-Acetamidophenol (Standard)	Others	Inflammation/Immunology
2-Acetamidophenol (Standard) is the analytical standard of 2-Acetamidophenol. This product is intended for research and analytical applications. Paracetamol (4-acetamidophenol). 2-Acetamidophenol is a promising analgesic and an anti-arthritic agent .

HY-111149

PS372424	CXCR	Inflammation/Immunology
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation .

HY-111149A

PS372424 hydrochloride 1 Publications Verification	CXCR	Inflammation/Immunology
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation .

HY-N0705

Curculigoside Maximum Cited Publications 6 Publications Verification	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-108065

3'-Sialyllactose 3'-SL	NF-κB	Inflammation/Immunology
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-108065A

3'-Sialyllactose sodium 3'-SL sodium	NF-κB	Inflammation/Immunology
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-136540S

Resolvin D3-d5 RvD3-d₅	Isotope-Labeled Compounds	Inflammation/Immunology
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis ^[1][4].

HY-Y0585R

D-(-)-Mandelic acid (Standard)	Bacterial	Infection Inflammation/Immunology
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-129566

Withanolide B	ERK Wnt β-catenin	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N8458

Cryogenine NSC 272693	Others	Inflammation/Immunology
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC₅₀=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.

HY-18759

BMS-751324	p38 MAPK TNF Receptor	Inflammation/Immunology
BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model .

HY-N0705R

Curculigoside (Standard)	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-N2923

β-Amyrin acetate	HMG-CoA Reductase (HMGCR) Fungal	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase .

HY-12511

SKF-86002 3 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-108641

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-129566R

Withanolide B (Standard)	ERK Wnt β-catenin	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-163368

HDAC6-IN-34	HDAC	Inflammation/Immunology
HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC₅₀ of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat .

HY-115913

PDE4-IN-6	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC₅₀s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects .

Cat. No.	Product Name	Target	Research Area

HY-P0107A

RC-3095 TFA 1 Publications Verification	Bombesin Receptor	Inflammation/Immunology
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-P0107

RC-3095	Bombesin Receptor	Inflammation/Immunology
RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2513

β-Boswellic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-N5010

Nepitrin Nepetin-7-glucoside	Flavonoids Classification of Application Fields Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-N6647

Luteolin-7-rutinoside	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Fungal
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

HY-N0705

Curculigoside 5+ Cited Publications	Curculigo orchioides Gaertn. Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Plants Amaryllidaceae Disease Research Fields Cancer	JAK STAT NF-κB
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-108065A

3'-Sialyllactose sodium 3'-SL sodium	Structural Classification Polysaccharides Animals Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Saccharides	NF-κB
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Rosaceae Other Diseases Armeniaca vulgaris Lam. Plants Endogenous metabolite Disease Research Fields	Bacterial
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis ^[1][4].

HY-120529

Aciculatin	Structural Classification Flavonoids Flavones Gramineae Source classification Plants Themeda arguens (L.) Hack.	Others
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

HY-N5010R

Nepitrin (Standard)	Structural Classification Flavonoids Flavones Labiatae Source classification Cassia Phenols Polyphenols Plants	Others
Nepitrin (Standard) is the analytical standard of Nepitrin. This product is intended for research and analytical applications. Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-108065

3'-Sialyllactose 3'-SL	Structural Classification Natural Products Classification of Application Fields Animals Inflammation/Immunology Disease Research Fields	NF-κB
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-Y0585R

D-(-)-Mandelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Rosaceae Armeniaca vulgaris Lam. Plants Endogenous metabolite	Bacterial
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-129566

Withanolide B	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids	ERK Wnt β-catenin
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0705R

Curculigoside (Standard)	Curculigo orchioides Gaertn. Structural Classification Monophenols Source classification Phenols Plants Amaryllidaceae	JAK STAT NF-κB
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-N2923

β-Amyrin acetate	Triterpenes Structural Classification Ficus exasperata Vahl Source classification Plants Moraceae	HMG-CoA Reductase (HMGCR) Fungal
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase .

HY-129566R

Withanolide B (Standard)	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	ERK Wnt β-catenin
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

Cat. No.	Product Name	Chemical Structure

HY-136540S

Resolvin D3-d5
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].

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arthritic

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products