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Results for "

atypical antipsychotic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (41) Adrenergic Receptor (17) Apoptosis (4) Autophagy (4) Dopamine Receptor (44) Drug Metabolite (8) Histamine Receptor (4) Isotope-Labeled Compounds (8) mAChR (7) Mitophagy (4) Opioid Receptor (3) Sigma Receptor (3) Virus Protease (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (3) Infection (6) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (49)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0019A

Paliperidone palmitate 9-Hydroxyrisperidone palmitate	Dopamine Receptor 5-HT Receptor	Neurological Disease
Paliperidone palmitate (9-Hydroxyrisperidone palmitate), an atypical long-acting antipsychotic agent, is an ester proagent of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia .

HY-17410

Iloperidone 1 Publications Verification HP 873	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-B0731A

Perospirone SM-9018 free base	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT_2A receptor (K_i=0.6 nM) and dopamine D₂ receptor (K_i=1.4 nM), and also a partial agonist of 5-HT_1A receptor (K_i=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-B0731

Perospirone hydrochloride SM-9018	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT_1A receptor (K_i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-17410S1

Iloperidone-d3 hydrochloride	Dopamine Receptor 5-HT Receptor Isotope-Labeled Compounds	Neurological Disease
Iloperidone-d₃ hydrochloride is deuterated labeled Iloperidone (HY-17410). Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-119389

RGH-1756	Dopamine Receptor 5-HT Receptor	Neurological Disease
RGH-1756 is an atypical antipsychotic that has a strong and selective antagonist activity on human D₃ and less pronounced activity on human D_2L and 5HT_1A receptors .

HY-118575

DR-4004	5-HT Receptor	Neurological Disease
DR-4004 is a 5-HT₇ receptor antagonist that attenuates the decreased level of performance produced by mCPP and the performance levels after p-chloroamphetamine (PCA) lesion of the 5-HT system. DR-4004 also reverses amnesia induced by Scopolamine (HY-N0296) and Dizocilpine (HY-15084B). DR-4004 is promising for research of schizophrenia, cognitive deficits and atypical antipsychotic agents .

HY-B0731R

Perospirone hydrochloride (Standard)	5-HT Receptor Dopamine Receptor	Neurological Disease
Perospirone (hydrochloride) (Standard) is the analytical standard of Perospirone (hydrochloride). This product is intended for research and analytical applications. Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT_2A receptor (K_i of 0.6 nM) and dopamine D₂ receptor (K_i of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT_1A receptor (K_i of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research .

HY-118127

Rilapine	Others	Neurological Disease
Rilapine is an atypical antipsychotic agent .

HY-G0002

Lurasidone metabolite 14326	Drug Metabolite	Neurological Disease
Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone.

HY-G0002A

Lurasidone metabolite 14326 hydrochloride	Drug Metabolite	Neurological Disease
Lurasidone metabolite 14326 (hydrochloride) is an active metabolite of the atypical antipsychotic Lurasidone.

HY-117083

Clothiapine	5-HT Receptor	Neurological Disease
Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties .

HY-G0003

Iloperidone metabolite Hydroxy Iloperidone P88; Hydroxy Iloperidone	Drug Metabolite	Others
Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is a metabolite of Iloperidone, which is an atypical antipsychotic.

HY-13575S

Blonanserin-d8 AD-5423 d₈	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-13575S1

Blonanserin-d5 AD-5423-d₅	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-B1059

Levosulpiride RV-12309; S-(-)-Sulpiride	Dopamine Receptor	Neurological Disease
Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class.

HY-W741839

Aripiprazole N,N-Dioxide	Others	Metabolic Disease
Aripiprazole N,N-dioxide is a metabolite of the atypical antipsychotic aripiprazole (HY-14546). It is formed from aripiprazole via oxidation.

HY-17410A

Iloperidone hydrochloride HP 873 hydrochloride	5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone hydrochloride (HP 873 hydrochloride) is a D₂/5-HT₂ receptor antagonist. Iloperidone hydrochloride is an atypical antipsychotic for the schizophrenia symptoms .

HY-121301

Amperozide	5-HT Receptor	Neurological Disease
Amperozide is an atypical antipsychotic that acts as an antagonist of the 5-HT2 receptor with a K_i value of 26 nM. Amperozide has a low affinity for D2 receptors .

HY-B1059S

Levosulpiride-d3 RV-12309-d₃; S-(-)-Sulpiride-d₃	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Levosulpiride-d₃ is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class[1][2].

HY-B1059R

Levosulpiride (Standard)	Dopamine Receptor	Neurological Disease
Levosulpiride (Standard) is the analytical standard of Levosulpiride. This product is intended for research and analytical applications. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class.

HY-17410S

Iloperidone-d3	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Iloperidone-d₃ is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2].

HY-B1019

Sulpiride 5+ Cited Publications	Dopamine Receptor	Neurological Disease
Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

HY-13575A

Blonanserin dihydrochloride AD-5423 dihydrochloride	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Cardiovascular Disease Neurological Disease
Blonanserin dihydrochloride is a potent and orally active 5-HT_2A and dopamine D2 receptor antagonist, with K_i values of 0.812 and 0.142 nM, respectively. Blonanserin dihydrochloride is usually acts as an atypical antipsychotic agent, and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension .

HY-10121

Asenapine 1 Publications Verification Org 5222	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-10121B

Asenapine citrate Org 5222 citrate	5-HT Receptor Dopamine Receptor Adrenergic Receptor Histamine Receptor	Neurological Disease
Asenapine citrate, an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine citrate can be used in the research of schizophrenia and bipolar disorder .

HY-B1019R

Sulpiride (Standard)	Dopamine Receptor	Neurological Disease
Sulpiride (Standard) is the analytical standard of Sulpiride. This product is intended for research and analytical applications. Sulpiride is an orally active dopamine D2/D3 receptor antagonist. Sulpiride is an atypical antipsychotic agent of the benzamide family. Sulpiride can be used in research into anxiety, depression and breast cancer .

HY-13575

Blonanserin AD-5423	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Cardiovascular Disease Neurological Disease
Blonanserin (AD-5423) is a potent?and orally active 5-HT_2A?(K_i=0.812 nM) and?dopamine D2?receptor?(K_i=0.142?nM)?antagonist. Blonanserin is usually acts as an atypical antipsychotic?agent and can be used for the research of extrapyramidal symptoms, excessive?sedation, or?hypotension .

HY-G0021

N-Desmethylclozapine Norclozapine; Desmethylclozapine; Normethylclozapine	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .

HY-10121R

Asenapine (Standard)	5-HT Receptor Adrenergic Receptor Dopamine Receptor Histamine Receptor	Neurological Disease Endocrinology
Asenapine (Standard) is the analytical standard of Asenapine. This product is intended for research and analytical applications. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-13575R

Blonanserin (Standard)	5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Neurological Disease
Blonanserin (Standard) is the analytical standard of Blonanserin. This product is intended for research and analytical applications. Blonanserin (AD-5423) is a potent and orally active 5-HT_2A (K_i=0.812 nM) and dopamine D2 receptor (K_i=0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension .

HY-15780S

Brexpiprazole-d8 OPC-34712-d₈	5-HT Receptor Dopamine Receptor	Neurological Disease
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-10121S2

Asenapine-13C,d3 Org 5222-13C,d3	Adrenergic Receptor Histamine Receptor 5-HT Receptor Dopamine Receptor Isotope-Labeled Compounds	Neurological Disease Endocrinology
Asenapine- ¹³C,d₃ is ¹³C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-14782A

Adoprazine hydrochloride SLV313 hydrochloride	5-HT Receptor Dopamine Receptor
Adoprazine (SLV313) hydrochloride is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine hydrochloride is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics .

HY-A0019

Paliperidone 3 Publications Verification 9-Hydroxyrisperidone	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-A0019R

Paliperidone (Standard)	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor	Neurological Disease
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-133152

Brexpiprazole S-oxide DM-3411	5-HT Receptor Dopamine Receptor	Neurological Disease
Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT_1A and dopamine receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT_2A receptor antagonist with a K_i of 0.47 nM .

HY-14327

FAUC 213	Dopamine Receptor	Neurological Disease
FAUC 213 is an orally active and highly selective dopamine D₄ receptor complete antagonist with a K_i of 2.2 nM for hD_4.4. FAUC 213 has less activity on D₂ and D₃ receptors (K_is of 3.4 μM, 5.3 μM for hD₂, hD₃, respectively). FAUC 213 can cross the blood-brain barrier (BBB). FAUC 213 exhibits atypical antipsychotic characteristic .

HY-14782

Adoprazine SLV313	5-HT Receptor Dopamine Receptor	Neurological Disease
Adoprazine (SLV313) is a full 5-HT_1A receptor agonist with a pEC₅₀ of 9 at cloned h5-HT_1A receptors. Adoprazine (SLV313) is a full D₂ and D₃ receptor antagonist with pA₂s of 9.3 and 8.9 at hD₂ and hD₃ receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics .

HY-G0021S

N-Desmethylclozapine-d8 Norclozapine-d₈; Desmethylclozapine-d₈; Normethylclozapine-d₈	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride Norclozapine-d₈ hydrochloride; Desmethylclozapine-d₈ hydrochloride; Normethylclozapine-d₈ hydrochloride	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-14546

Aripiprazole Maximum Cited Publications 8 Publications Verification OPC-14597	5-HT Receptor Dopamine Receptor	Infection Neurological Disease Inflammation/Immunology
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19 .

HY-15780

Brexpiprazole 3 Publications Verification OPC-34712	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM) .

HY-133152S

Brexpiprazole S-oxide-d8 DM-3411 d₈	Isotope-Labeled Compounds 5-HT Receptor Dopamine Receptor	Neurological Disease
Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-14546A

Aripiprazole monohydrate OPC-14597 monohydrate	5-HT Receptor Dopamine Receptor	Infection Neurological Disease Inflammation/Immunology
Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19 .

HY-15780A

Brexpiprazole hydrochloride OPC-34712 hydrochloride	5-HT Receptor Dopamine Receptor Adrenergic Receptor	Neurological Disease
Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D_2L receptor with K_is of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A receptor antagonist with a K_i of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α_1B (K_i=0.17 nM) and α_2C receptors (K_i=0.59 nM) .

HY-14541A

Olanzapine hydrochloride LY170053 hydrochloride	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Cancer
Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine hydrochloride is an atypical antipsychotic .

HY-14541

Olanzapine Maximum Cited Publications 8 Publications Verification LY170053	5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis	Neurological Disease Cancer
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

HY-14546R

Aripiprazole (Standard) OPC-14597 (Standard)	5-HT Receptor Dopamine Receptor	Infection Neurological Disease Inflammation/Immunology
Aripiprazole (Standard) is the analytical standard of Aripiprazole. This product is intended for research and analytical applications. Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19 .

HY-15780S1

Brexpiprazole-d8-1 OPC-34712-d₈-1	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0019

Paliperidone 3 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-A0019R

Paliperidone (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

Cat. No.	Product Name	Chemical Structure

HY-B1059S

Levosulpiride-d3
Levosulpiride-d₃ is the deuterium labeled Levosulpiride. Levosulpiride (RV-12309) is the (S)-enantiomer of sulpiride, which is a D2 receptor a antagonist, an atypical antipsychotic agent of the benzamide class[1][2].

HY-15780S

Brexpiprazole-d8
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-17410S1

Iloperidone-d3 hydrochloride
Iloperidone-d₃ hydrochloride is deuterated labeled Iloperidone (HY-17410). Iloperidone (HP 873) is a D₂/5-HT₂ receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms .

HY-13575S

Blonanserin-d8
Blonanserin-d₈ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-13575S1

Blonanserin-d5
Blonanserin-d₅ is a deuterium labeled Blonanserin. Blonanserin is a dopamine D2/5-HT2 receptor antagonist and an atypical antipsychotic[1][2].

HY-17410S

Iloperidone-d3
Iloperidone-d₃ is the deuterium labeled Iloperidone. Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2].

HY-10121S2

Asenapine-13C,d3

Asenapine- ¹³C,d₃ is ¹³C and deuterated labeled Asenapine (HY-10121). Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pK_i: 8.4-10.5), adrenoceptors (pK_i: 8.9-9.5), dopamine receptors (pK_i: 8.9-9.4) and histamine receptors (pK_i: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder .

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist[1][2].

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

HY-14541S2

Olanzapine-d8

Olanzapine-d8 is a deuterated labeled Olanzapine . Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (K_i=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (K_i=11 to 31 nM), muscarinic M1-5 (K_i=1.9-25 nM), and adrenergic α1 receptor (K_i=19 nM). Olanzapine is an atypical antipsychotic .

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