2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor
  4. Blonanserin

Blonanserin  (Synonyms: AD-5423)

Cat. No.: HY-13575 Purity: 99.62%
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Blonanserin (AD-5423) is a potent?and orally active 5-HT2A?(Ki=0.812 nM) and?dopamine D2?receptor?(Ki =0.142?nM)?antagonist. Blonanserin is usually acts as an atypical antipsychotic?agent and can be used for the research of extrapyramidal symptoms, excessive?sedation, or?hypotension.

For research use only. We do not sell to patients.

Blonanserin Chemical Structure

Blonanserin Chemical Structure

CAS No. : 132810-10-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Blonanserin:

Blonanserin Related Antibodies

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Sigma 1 Receptor Sigma 2 Receptor

  • Biological Activity

  • Purity & Documentation

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Description

Blonanserin (AD-5423) is a potent?and orally active 5-HT2A?(Ki=0.812 nM) and?dopamine D2?receptor?(Ki =0.142?nM)?antagonist. Blonanserin is usually acts as an atypical antipsychotic?agent and can be used for the research of extrapyramidal symptoms, excessive?sedation, or?hypotension[1].

IC50 & Target[1][2]

D2 Receptor

0.142 nM (Ki)

D3 Receptor

0.494 nM (Ki)

D4 Receptor

150 nM (Ki)

D1 Receptor

1070 nM (Ki)

5-HT2A Receptor

0.812 nM (Ki)

5-HT2C Receptor

26.4 nM (Ki)

5-HT6 Receptor

11.7 nM (Ki)

α1-adrenergic receptor

26.7 (Rat nM (Ki)

α2-adrenergic receptor

530 (Rat c nM (Ki)

In Vitro

Blonanserin exerts some blockade of?α1-adrenergic receptors?(Ki=26.7?nM) and also shows significant affinity for the?D3?receptor?(Ki=0.494 nM). Blonanserin possesses low affinity for the?sigma receptor?(IC50=286 nM), but lacks significant?affinity?for numerous other sites including the?5-HT1A,?5-HT3,?D1,?α2-adrenergic,?β-adrenergic,?H1, and?mACh receptors?and the?monoamine transporters[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Blonanserin Related Antibodies
In Vivo

Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice received saline or phencyclidine once a day for 14 consecutive days[2]
Dosage: 1 mg/kg
Administration: Oral gavage; 1 mg/kg; 14 days
Result: Had an effect on the social deficit in mice that received repeated PCP administration.
Clinical Trial
Molecular Weight

367.50

Formula

C23H30FN3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C2=C(CCCCCC3)C3=NC(N4CCN(CC)CC4)=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7211 mL 13.6054 mL 27.2109 mL
5 mM 0.5442 mL 2.7211 mL 5.4422 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.43 mg/mL (3.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.43 mg/mL (3.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7211 mL 13.6054 mL 27.2109 mL 68.0272 mL
5 mM 0.5442 mL 2.7211 mL 5.4422 mL 13.6054 mL
10 mM 0.2721 mL 1.3605 mL 2.7211 mL 6.8027 mL
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Blonanserin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blonanserin132810-10-7AD-5423AD5423AD 54235-HT ReceptorDopamine ReceptorAdrenergic ReceptorSigma ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorantipsychoticschizophreniaextrapyramidal symptomexcessive sedationhypotensionsocial deficitInhibitorinhibitorinhibit

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