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Isoforms Recommended:	Phospholipase A

Results for "

cPLA2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) COX (1) DAGL (1) Endogenous Metabolite (4) FAAH (1) Integrin (1) Isotope-Labeled Compounds (1) MAGL (1) Phosphatase (1) Phospholipase (23)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Inflammation/Immunology (16) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W654264

2-Methylbutyrylcarnitine chloride	Endogenous Metabolite Integrin	Cardiovascular Disease
2-Methylbutyrylcarnitine (chloride) is a gut microbial metabolite which binds to integrin *α2β1* in platelets, potentiating cytosolic phospholipase A2 (cPLA2) activation and platelet hyperresponsiveness. 2-Methylbutyrylcarnitine (chloride) enhances platelet hyperreactivity and thrombus formation in mice. 2-Methylbutyrylcarnitine (chloride) is a branched-chain acylcarnitine .

HY-103334

MAFP 4 Publications Verification Methyl Arachidonyl Fluorophosphonate	Phospholipase	Cardiovascular Disease Neurological Disease Metabolic Disease
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of *cPLA2* and *iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase*.

HY-14952

Giripladib PLA-695	Phospholipase	Inflammation/Immunology Cancer
Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A₂ (cPLA₂). Giripladib can be used for osteoarthritis and breast cancer research ^[2].

HY-138871

cPLA2α-IN-derivative 1	Phospholipase	Inflammation/Immunology
cPLA2α-IN-derivative 1 is an inactive alcohol derivative of a highly potent Cytosolic phospholipase A2α (cPLA2α) inhibitor .

HY-162368

cPLA2α-IN-2	Phospholipase	Others
cPLA2α-IN-2 (Compound 122) is an inhibitor of cytosolic phospholipase A₂α (cPLA₂α) .

HY-D1647

7-Hydroxycoumarinyl-γ-linolenate	Phospholipase	Others
7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A₂ (cPLA₂) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA₂ .

HY-162228

VI-60	COX Phospholipase	Inflammation/Immunology
VI-60 is a dual, orally active inhibitor of *cPLA₂* and *COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA₂/COX-2/PGE₂* pathway .

HY-W127380

Arachidonoyl thio-PC	Biochemical Assay Reagents	Others
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-127110

AK106-001616	Phospholipase	Others Neurological Disease Inflammation/Immunology
AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC₅₀=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis .

HY-112738

AX048	Phospholipase	Inflammation/Immunology
AX048 is an inhibitor for calcium-dependent phospholipase A2 *cPLA₂* with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy .

HY-N0134

Tanshinone I 4 Publications Verification Tanshinone A	Phospholipase	Cardiovascular Disease Cancer
Tanshinone I is an inhibitor of type IIA human recombinant *sPLA₂* (IC₅₀=11 μM) and rabbit recombinant *cPLA₂* (IC₅₀=82 μM).

HY-N0134R

Tanshinone I (Standard)	Phospholipase	Cardiovascular Disease Cancer
Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC₅₀=11 μM) and rabbit recombinant cPLA2 (IC₅₀=82 μM).

HY-W713925

Diheptanoyl Thio-PC	Endogenous Metabolite	Metabolic Disease
Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.

HY-138990

GK563	Phospholipase Apoptosis	Inflammation/Immunology
GK563 is a selective Ca ²⁺-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an IC₅₀ value of 1 nM. GK563 is 22000 times more active against GVIA iPLA₂ than GIVA cPLA₂. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes .

HY-18540

KT109	DAGL MAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages .

HY-149654

*FAAH/cPLA2α-IN-1*	FAAH Phospholipase	Neurological Disease Inflammation/Immunology
FAAH/cPLA2α-IN-1 is a dual inhibitor of FAAH and *cPLA2α* with IC₅₀s of 32 and 47 nM, respectively .

HY-108611

AACOCF3 3 Publications Verification Arachidonyl trifluoromethyl ketone	Phospholipase	Cardiovascular Disease
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease ^[2] .

HY-120050

GK470	Phospholipase	Inflammation/Immunology
GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA₂) with an IC₅₀ of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC₅₀ value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE₂ levels .

HY-19920

AVX001 AKH-217	Phospholipase	Inflammation/Immunology
AVX001 is an inhibitor of phospholipase A2 (cPLA2α) that can be used in the research of psoriasis .

HY-W019838

D-Erythro-dihydrosphingosine Sphinganine (d18:0)	Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A₂α (cPLA₂α) activity.

HY-106253

Efipladib	Phospholipase	Inflammation/Immunology
Efipladib is a potent, selective and orally active *cPLA₂α* inhibitor with an IC₅₀ of 0.04 μM and a K_d of 0.067 μM .

HY-111376

Pyrrophenone 3 Publications Verification	Phospholipase	Cardiovascular Disease Inflammation/Immunology
Pyrrophenone is a potent and specific cytosolic phospholipase A₂α (cPLA₂α) inhibitor with an IC₅₀ value of 4.2 nM .

HY-119019

ASB14780 1 Publications Verification	Phosphatase	Inflammation/Immunology
ASB14780 is a 4-phenoxy derivative, the cytosolic Phospholipase A₂α (cPLA₂α) inhibitor, with an IC₅₀ value of 20 nM .

HY-W019838S

D-Erythro-dihydrosphingosine-d7 Sphinganine (d18:0)-d₇	Isotope-Labeled Compounds Endogenous Metabolite Phospholipase	Cancer
D-Erythro-dihydrosphingosine-d₇ is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

HY-10801

CAY10650 Maximum Cited Publications 8 Publications Verification	Phospholipase	Inflammation/Immunology
CAY10650 is a highly potent cytosolic phospholipase A2α *(cPLA2α)* inhibitor with an IC₅₀ value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion ^[2].

HY-U00037

Ecopladib PLA 725	Phospholipase	Inflammation/Immunology
Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC₅₀s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blood assays, respectively.

HY-116301

CAY10502	Phospholipase	Inflammation/Immunology
CAY10502 is a potent, calcium-dependent cytosolic phospholipase A2 α (cPLA₂α) inhibitor with an IC₅₀ of 4.3 nM for isolated enzyme. CAY10502 can be used in the research of retinopathy and inflammatory diseases ^[2] .

HY-168431

GK420 AVX420	Phospholipase	Cancer
GK420 (AVX420) is a potent inhibitor of cytosolic phospholipase A2α (cPLA2α), with the X_I(50) of 0.0016. GK420 inhibits arachidonic acid release with the EC₅₀ of 0.09 μM. GK420 plays an important role in cancer research .

Cat. No.	Product Name	Type

HY-D1647

7-Hydroxycoumarinyl-γ-linolenate	Chromogenic Substrates
7-Hydroxycoumarinyl-γ-linolenate is a cytosolic phospholipase A₂ (cPLA₂) fluorogenic substrate. 7-Hydroxycoumarinyl-γ-linolenate can be used to monitor the enzymatic activity of cPLA₂ .

HY-W713925

Diheptanoyl Thio-PC	Dyes
Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH).1 Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.

Cat. No.	Product Name	Type

HY-W127380

Arachidonoyl thio-PC	Enzyme Substrates
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

Arachidonoyl thio-PC

Enzyme Substrates

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

Cat. No.	Product Name	Category	Target	Chemical Structure