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fluorescence quenching

" in MedChemExpress (MCE) Product Catalog:

32

Inhibitors & Agonists

19

Fluorescent Dye

3

Biochemical Assay Reagents

5

Peptides

3

MCE Kits

1

Click Chemistry

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D1045
    Dabcyl acid

    DABCYL; Para-methyl red

    		 Fluorescent Dye Others
    Dabcyl acid (Dabcyl) is the original dark fluorescence quencher.
    Dabcyl acid
  • HY-D1030
    Fluorescein Biotin

    		Fluorescent Dye Inflammation/Immunology
    Fluorescein Biotin is used as an alternative to radioactive biotin for detecting and quantitating biotin-binding sites by either fluorescence or absorbance; the the fluorescence or absorbance of Fluorescein Biotin is quenched, upon binding to avidin or streptavidin.
    Fluorescein Biotin
  • HY-W012642
    2-Aminopurine

    		DNA Stain Others
    2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics .
    2-Aminopurine
  • HY-P4920
    Mca-SEVNLDAEFK(Dnp)-NH2

    		Fluorescent Dye Others
    Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .
    Mca-SEVNLDAEFK(Dnp)-NH2
  • HY-D1663
    APTAB

    		Fluorescent Dye Others
    APTAB is a fluorescent cationic membrane probe. APTAB locates the anthracene-labeled molecules incorporated into model membranes by fluorescence quenching .
    APTAB
  • HY-173308
    QSY-21

    		Fluorescent Dye Others
    QSY-21 is a fluorescence quencher. QSY-21 possesses broad absorption in far red and NIR range, and can quench fluorescence of dyes that emit in this region. This is a carboxylic acid derivative. QSY-21 has intense absorption maximum at 661 nm, making it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications. It is a common quencher for Cyanine5, Cyanine5.5, AF 647, or other spectrally similar fluorescent dyes.
    QSY-21
  • HY-W012642A
    2-Aminopurine dihydrochloride

    		DNA Stain Others
    2-Aminopurine dihydrochloride is a fluorescent analog of guanosine. 2-Aminopurine dihydrochloride can be used as a fluorescence probe for nucleic acid structure and dynamics. Incorporating 2-Aminopurine dihydrochloride into DNA quenches its fluorescence .
    2-Aminopurine dihydrochloride
  • HY-170466
    16:0-12 Doxyl PC

    1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine

    		 Biochemical Assay Reagents Others
    16:0-12 Doxyl PC (1-Palmitoyl-2-stearoyl-(12-doxyl)-sn-glycero-3-phosphocholine) is a fluorescence quencher, and its nitrogen oxide is located downstream of the sn-2 chain. 16:0-12 Doxyl PC has a better fluorescence quenching effect onthe fluorophore is buried within the hydrocarbon interior of the bilayer .
    16:0-12 Doxyl PC
  • HY-D2579
    Sulfo DBCO-UBQ-2

    		Biochemical Assay Reagents Others
    Sulfo DBCO-UBQ-2 is a click chemistry reagent combining a dark quencher, UBQ-2, with a polyaromatic-azo backbone, offering no native emission. UBQ-2 effectively quenches fluorescence in the 560-670 nm range, ideal for qPCR probes and FRET applications with orange to far-red dyes .
    Sulfo DBCO-UBQ-2
  • HY-126965
    Lipid Y

    		Biochemical Assay Reagents Others
    Lipid Y is a potent monosaccharide which contains two bromines per chain. lipid Y binds to a tryptophan residue in a membrane protein and then quenches the fluorescence of the tryptophan residue .
    Lipid Y
  • HY-118213
    N-(2-Hydroxyethyl)-1,8-naphthalimide

    		Fluorescent Dye Others
    N-(2-Hydroxyethyl)-1,8-naphthalimide is a fluorescent probe for detecting nucleic acids and their precursors. The fluorescence of N-(2-Hydroxyethyl)-1,8-naphthalimide will be quenched by these molecules.
    N-(2-Hydroxyethyl)-1,8-naphthalimide
  • HY-163204
    RhQ-DMB

    		P-glycoprotein Cancer
    RhQ-DMB is a potent inhibitor of P-gp. RhQ-DMB exhibits high affinity and inhibitory activity in yeast strains expressing CmABCB1 .
    RhQ-DMB
  • HY-42984
    BHQ-2 NHS

    		Biochemical Assay Reagents Others
    BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. UBHQ-2 NHS has a wide and intense quenching range from 560-670 nm, which makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
    BHQ-2 NHS
  • HY-D0720
    Lucigenin
    5+ Cited Publications

    NSC-151912; L-6868

    		 Fluorescent Dye Reactive Oxygen Species Others
    Lucigenin is a chemiluminescence probe. Lucigenin can be used to detect the production of endogenous superoxide anion radical (O 2-). Lucigenin is extremely sensitive to chloride ions, while it combined with chloride ions, the fluorescence will be quenched. Lucigenin also can be used as a chloride indicator. Ex/Em=455/505 nm .
    Lucigenin
  • HY-P4919
    Mca-SEVNLDAEFK(Dnp)

    		Beta-secretase Others
    Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
    Mca-SEVNLDAEFK(Dnp)
  • HY-126823
    Phen Green SK diacetate (5/6-mixture)
    Maximum Cited Publications
    7 Publications Verification

    PGSK diacetate (5/6-mixture)

    		 Fluorescent Dye Others
    Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+. PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions
    Phen Green SK diacetate (5/6-mixture)
  • HY-D1590
    BODIPY Green 8-P2M

    		Fluorescent Dye Others
    ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .
    BODIPY Green 8-P2M
  • HY-160062
    S2.2 aptamer sodium

    		Mucin Cancer
    S2.2 aptamer sodium is a nucleic acid aptamer targeting the mucin MUC1 and can be used for targeted imaging of MCF-7 cancer cells. S2.2 aptamer sodium was labeled with Cy5, and when fluorescent silicon nanodots (SiND) were present, the fluorescence was quenched; when MUC1 was also present, the fluorescence was restored. S2.2 aptamer sodium detects MUC1 with a linear range of 3.33-250 nM .
    S2.2 aptamer sodium
  • HY-D2761
    DY-680-NHS ester

    		Fluorescent Dye Others
    DY-680-NHS ester is an amine reactive hydrophilic fluorochrome. It can be conjugated to an antibody with higher D/P ratio without causing fluorescence quenching and conjugate precipitation, and it is widely used in applications including western blotting, microscopy, flow cytometry, and cell-based assays. The spectrum has an excitation of 690nm and emission at 709nm.
    DY-680-NHS ester
  • HY-D1682
    NFQ1

    		Fluorescent Dye Others
    NFQ1 is a non-fluorescent quencher (absorption wavelength: 474 nm), and is used for a new type of One Sample Fluorescence Resonance Energy Transfer (OS-FRET) method. OS-FRET enable measurement of unquenched donor emission in the same sample. NFQ1 shows broad absorption spectrum ensuring its utility as a dark acceptor for many donors .
    NFQ1
  • HY-P10922
    Cathepsin E substrate e

    		Cathepsin Others
    Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence .
    Cathepsin E substrate e
  • HY-P3749
    Mca-(ala7,lys(dnp)9)-bradykinin

    		Fluorescent Dye Others
    Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .
    Mca-(ala7,lys(dnp)9)-bradykinin
  • HY-D2365
    QSY 21 NHS

    		Fluorescent Dye Others
    QSY 21 NHS, a dark quencher is an efficient energy transfer acceptor of the far red and NIR fluorescent probes. QSY 21 NHS works in the wavelength range of 540-750 nm, and is frequently used in FRET applications. QSY 21 NHS does not emit fluorescence in normal conditions. NHS esters can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules .
    QSY 21 NHS
  • HY-D2735
    QSY-9-succinimidyl ester

    		Fluorescent Dye Others
    QSY-9-succinimidyl ester is a nonfluorescent acceptor molecule with a terminal NHS ester group. QSY-9-succinimidyl ester has a wide and intense quenching range from 500-600 nm that makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with fluorescent dyes at 500 nm to 600 nm. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
    QSY-9-succinimidyl ester
  • HY-W142692
    Dodecyl β-D-glucopyranoside

    		Biochemical Assay Reagents Others
    Dodecyl β-D-glucopyranoside is a non-ionic detergent and surfactant commonly used to solubilize and purify membrane proteins in biochemical research. Dodecyl β-D-glucopyranoside also interacts with bovine serum albumin (BSA) to quench its intrinsic fluorescence. The critical micelle concentration (CMC) of Dodecyl β-D-glucopyranoside (DG) and DG/BSA complex is 2.0 mM and 2.34 mM, respectively. Micelles can be formed in aqueous solutions above this concentration .
    Dodecyl β-D-glucopyranoside
  • HY-D2204
    SHP1-IN-1

    		Phosphatase Fluorescent Dye Cancer
    SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe 3+ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .
    SHP1-IN-1
  • HY-W127832
    Ru(dpp)3(PF6)2

    		Fluorescent Dye Others
    Ru(dpp)3(PF6)2 is a complex containing metallic ruthenium (Ru) and is a chemiluminescent oxygen probe. [Ru(dpp)3] 2+ is a luminescent substance that can undergo metal-to-ligand charge transfer (MLCT), and fluorescence will appear during the transfer of Ru to the ligand. At the same time, the fluorescence of Ru(dpp)3(PF6)2 is effectively quenched by molecular oxygen, so it is widely used in biosensors, environmental monitoring, and materials science. The property of Ru(dpp)3(PF6)2, which oxidizes Ru 2+ to Ru 3+, has also been used to design and construct solid-state light-emitting electrochemical cells .
    Ru(dpp)3(PF6)2
  • HY-123630
    Allura Red AC

    FD&C RED NO. 40; CI 16035

    		 5-HT Receptor TNF Receptor IFNAR Reactive Oxygen Species Interleukin Related Inflammation/Immunology
    Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .
    Allura Red AC
  • HY-172309
    UBQ-3 NHS ester

    		Fluorescent Dye Others
    UBQ-3 NHS Ester is a fluroescent agent with a terminal NHS ester group. UBQ-3 NHS Ester has a wide quenching range from 620-730 nm, which makes the compound useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with far-red to near-IR emitting dyes such as Cy5, Cy5.5, Alexa Fluor 633, 647, 700. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
    UBQ-3 NHS ester
  • HY-W127716
    Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2
    1 Publications Verification

    		 Fluorescent Dye Cancer
    Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .
    Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2
  • HY-123630R
    Allura Red AC (Standard)

    		Fluorescent Dye Interleukin Related 5-HT Receptor IFNAR Reactive Oxygen Species Inflammation/Immunology
    Allura Red AC (Standard) is an analytical standard of Allura Red AC. This product is intended for research and analytical applications. Allura Red AC is a food colorant, appearing as a deep red water-soluble powder or granules, used in various applications such as beverages, syrups, candies, and cereals. Allura Red AC can statically quench the intrinsic fluorescence of HSA. Additionally, Allura Red AC is a 5-hydroxytryptamine (5-HT) pathway-associated pro-inflammatory agent, capable of exacerbating experimental colitis. Allura Red AC holds potential for research in inflammatory bowel disease (IBD), intestinal barrier function, and food additive safety .
    Allura Red AC (Standard)
  • HY-43520
    BODIPY-FL

    		Fluorescent Dye Others
    BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. BODIPY-FL-labeled sphingolipid analogs can be used to investigate sphingolipid internalization, transport, and endocytosis in mouse embryonic stem cells. BODIPY-FL-labeled monoterpenes can quickly penetrate bacteria, mammalian, and fungal cells, allowing for the detection of characteristics of a broad spectrum of Gram-positive and Gram-negative bacteria, as well as pathogenic fungi. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .
    BODIPY-FL

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