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hexokinase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Hexokinase (17) Antibiotic (1) Apoptosis (8) Autophagy (1) Drug Derivative (1) HSV (5) Isotope-Labeled Compounds (5) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Parasite (2) PROTACs (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Hexokinase Glucokinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134929

Hexokinase 2 inhibitor 1	Hexokinase	Infection Cancer
Hexokinase 2 inhibitor 1 (Compound 2a) is a hexokinase 2 (HK2) inhibitor with anti-tumor activity and can be used in cancer research .

HY-19992

3-Bromopyruvic acid 20+ Cited Publications Bromopyruvic acid; hexokinase II inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

HY-13966S

2-Deoxy-D-glucose-d1 2-DG-d₁; 2-Deoxy-D-arabino-hexose-d₁; D-Arabino-2-deoxyhexose-d₁	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S2

2-Deoxy-D-glucose-13C 2-DG-¹³C; 2-Deoxy-D-arabino-hexose-¹³C; D-Arabino-2-deoxyhexose-¹³C	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-139409A

2-Deoxy-D-glucose 6-phosphate disodium 1 Publications Verification	Drug Derivative	Metabolic Disease
2-Deoxy-D-glucose 6-phosphate disodium, a derivative of 2-Deoxy-D-glucose, is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-W000133

Metrizamide Amipaque	Hexokinase	Neurological Disease
Metrizamide (Amipaque) is used as the contrast medium for angiography in neuroradiological investigations . Metrizamide inhibits human brain hexokinase .

HY-168717

Antitumor agent-190	Hexokinase Microtubule/Tubulin Reactive Oxygen Species	Cancer
Antitumor agent-190 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC₅₀ value of 0.764 μM against MD-MBA-231 cells. Antitumor agent-190 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle .

HY-13966S4

2-Deoxy-D-glucose-13C-1 2-DG-¹³C-1; 2-Deoxy-D-arabino-hexose-¹³C-1; D-Arabino-2-deoxyhexose-¹³C-1	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-169728

SID 24785302	Hexokinase	Cardiovascular Disease Neurological Disease
SID 24785302 is an inhibitor for *hexokinase. SID 24785302 inhibits* glycolysis, regulates mitochondrial functions, thereby inhibiting the replication of mutant mtDNA .

HY-13966

2-Deoxy-D-glucose Maximum Cited Publications 209 Publications Verification 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Hexokinase HSV Apoptosis	Cancer
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-111331

Germicidin B	Antibiotic Hexokinase	Infection
Germicidin B is an antibiotic with bactericidal properties. Germicidin B can inhibit hexokinase II, with an IC₅₀ of 25.16 μM .

HY-B0486

Lonidamine 5+ Cited Publications AF-1890; Diclondazolic Acid; DICA	Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-155008

PROTAC HK2 Degrader-1 2 Publications Verification	PROTACs Hexokinase	Cancer
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

HY-B0486R

Lonidamine (Standard)	Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (Standard) is the analytical standard of Lonidamine. This product is intended for research and analytical applications. Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-13966S3

2-Deoxy-D-glucose-13C6 2-DG-¹³C₆; 2-Deoxy-D-arabino-hexose-¹³C₆; D-Arabino-2-deoxyhexose-¹³C₆	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-U00462

D-Mannoheptulose	Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-U00462S

D-Mannoheptulose-13C	Isotope-Labeled Compounds Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	888 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 888 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

888 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 888 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L009

Kinase Inhibitor Library	3,157 compounds
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. Kinase inhibitor library designed by MCE contains 3,157 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Kinase Inhibitor Library

3,157 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,157 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13966

2-Deoxy-D-glucose 205+ Cited Publications 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Hexokinase HSV Apoptosis
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-U00462

D-Mannoheptulose	Persea americana Mill Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Lauraceae Disease Research Fields Saccharides Monosaccharides	Hexokinase
D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-111331

Germicidin B	Structural Classification Microorganisms Antibiotics Source classification	Antibiotic Hexokinase
Germicidin B is an antibiotic with bactericidal properties. Germicidin B can inhibit hexokinase II, with an IC₅₀ of 25.16 μM .

Cat. No.	Product Name	Chemical Structure

HY-13966S

2-Deoxy-D-glucose-d1
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S2

2-Deoxy-D-glucose-13C
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S4

2-Deoxy-D-glucose-13C-1
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase[1][2].

HY-13966S3

2-Deoxy-D-glucose-13C6
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-U00462S

D-Mannoheptulose-13C
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

D-Mannoheptulose-13C

D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

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hexokinase inhibitor

Inhibitors & Agonists

Screening Libraries

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products