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Results for "

neuroscience

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (1) Adrenergic Receptor (1) Biochemical Assay Reagents (5) CDK (1) Cholinesterase (ChE) (1) Dopamine Receptor (3) Fluorescent Dye (2) LRRK2 (1) mTOR (1) Opioid Receptor (2) Potassium Channel (1) Sodium Channel (1)
By Research Areas:	Cancer (1) Endocrinology (1) Inflammation/Immunology (2) Neurological Disease (14)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4742A

6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) (TFA) 6-FAM-AEEAC-SHK TFA	Biochemical Assay Reagents Potassium Channel	Neurological Disease
6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research .

HY-133527

OG 488, SE Oregon green 488 succinimidyl ester	Fluorescent Dye	Neurological Disease
OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences .

HY-15796

GNE0877 2 Publications Verification	LRRK2	Neurological Disease
GNE0877 is a highly selective, orally active and brain-penetrant LRRK2 inhibitor with an IC₅₀ of 3 nM and a K_i of 0.7 nM. GNE0877 can be used for the research of neuroscience .

HY-D0904

Acetylthiocholine iodide S-Acetylthiocholine iodide; ATCh iodide	Biochemical Assay Reagents	Others
Acetylthiocholine iodide can be used as a substrate for certain enzymes, such as cholinesterase, etc., and can be used to determine the activity level of these enzymes. In addition, the compound is used in some medical research, for example in the fields of neuroscience and organ physiology.

HY-100939

4-Chlorophenylguanidine hydrochloride	Sodium Channel	Neurological Disease
4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo .

HY-W165085

1,10-Bis(pyridinium)decane Decamethylenebispyridinium dibromide	Cholinesterase (ChE)	Neurological Disease
1,10-Bis(pyridinium)decane is an acetylcholinesterase (AchE) inhibitor, with an IC₅₀ of 25.8 nM .

HY-W127702

Scopolamine nitrate Methscopolamine nitrate	Biochemical Assay Reagents	Others
Scopolamine (nitrate) is an organic compound commonly used in neuroscience research and pharmacology research. It can be used to study the role and structure of acetylcholine receptors, and is widely used in drug development and research in related fields. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.

HY-114539

L-750667 triHydrochloride	Dopamine Receptor	Neurological Disease
L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a K_i value of 0.51 nM. The radiolabeled form of L-750667, [ ¹²⁵I]L-750,667, has a K_d value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry .

HY-D1401

OG 488, acid	Fluorescent Dye	Others
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences .

HY-P5859

α-Pompilidotoxin α-PMTX	Biochemical Assay Reagents	Neurological Disease
α-Pompilidotoxin (α-PMTX) is a neurotoxin that can be obtained from the venom of Anoplius safnariensis. α-Pompilidotoxin reversibly and dose-dependently enhances excitatory postsynaptic currents (EPSCs). α-Pompilidotoxin is a useful tool in the field of neuroscience research .

HY-W127699

Propionylcholine (p-toluenesulfonate) N,N,N-Trimethyl-2-(propionyloxy)ethanaminium (p-toluenesulfonate)	Biochemical Assay Reagents	Others
Propionylcholine (p-toluenesulfonate) is an organic compound commonly used in biochemical research and neuroscience research. It can be used to study cholinergic signal transduction and esterase activity, and is widely used in biomedical research and pharmacological research. In addition, this compound is also used as a substrate or catalyst in certain biochemical reactions.

HY-106180

DTI 0009 GR 56072; RG 14202; Selodenoson	Adenosine Receptor	Neurological Disease
DTI 0009 is a selective adenosine A1 receptor agonist used to reduce heart rate in patients with atrial fibrillation and to treat arrhythmias .

HY-106933

Dabelotine	Adrenergic Receptor	Neurological Disease
Dabelotine is an adrenergic receptor agonist used in the study of dementia .

HY-12237

SKF 38393 hydrobromide (±)-SKF-38393 hydrobromide	Dopamine Receptor	Neurological Disease
SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM .

HY-114384B

NV-5138 hydrochloride 5 Publications Verification	mTOR	Neurological Disease
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies .

HY-14793

Lensiprazine	Dopamine Receptor	Neurological Disease
Lensiprazine is a potent dopamine D2 receptor (D2R) antagonist that acts as a serotonin reuptake inhibitor. Lensiprazine can be used to study bipolar disorder and schizophrenia .

HY-155805

CAF-382	CDK	Cancer
CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain .

HY-106769B

(3aR,9aR)-Fluparoxan (3aR,9aR)-GR50360	Others	Neurological Disease
(3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) is a highly selective and potent α2B adrenaline receptor antagonist with the activity of preventing, improving or inhibiting neurodevelopmental disorders and neurodegenerative diseases. As an α2B receptor antagonist, (3aR,9aR)-Fluparoxan can promote the recovery of neurological function. The mechanism of action of (3aR,9aR)-Fluparoxan makes it have important application potential in neuroscience research .

HY-19927A

DA-6886 monohydrochloride	5-HT Receptor	Neurological Disease Endocrinology
DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC₅₀ value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome .

HY-14157

ADL-5747	Opioid Receptor	Inflammation/Immunology
ADL-5747 is a selective and orally active agonist of the δ-opioid receptor (DOR). By binding to the δ-opioid receptors, ADL-5747 activates these receptors, thereby playing a role in pain management pathways. ADL-5747 can be used for research into pain management mechanisms .

HY-14157A

ADL-5747 hydrochloride	Opioid Receptor	Inflammation/Immunology
ADL-5747 hydrochloride is a selective and orally active agonist of the δ-opioid receptor (DOR). By binding to the δ-opioid receptors, ADL-5747 hydrochloride activates these receptors, thereby playing a role in pain management pathways. ADL-5747 hydrochloride can be used for research into pain management mechanisms .

Cat. No.	Product Name

HY-L030

Human Endogenous Metabolite Compound Library	981 compounds
The composition of endogenous metabolite compounds is affected by the upstream influence of the proteome and genome as well as environmental factors, lifestyle factors, medication, and underlying disease. Therefore, metabolites have been described as proximal reporters of disease because their abundances in biological specimens are often directly related to pathogenic mechanisms. In more recent years, metabolomics approach has been adopted or suggested to be used in various research areas including drug discovery, neurosciences, agriculture, food and nutrition, and environmental sciences. MCE owns a unique collection of 981 human endogenous metabolites, all of which are derived from human issues. This library is a powerful tool for metabonomics research and metabolism-related drug discovery.

Human Endogenous Metabolite Compound Library

981 compounds

The composition of endogenous metabolite compounds is affected by the upstream influence of the proteome and genome as well as environmental factors, lifestyle factors, medication, and underlying disease. Therefore, metabolites have been described as proximal reporters of disease because their abundances in biological specimens are often directly related to pathogenic mechanisms. In more recent years, metabolomics approach has been adopted or suggested to be used in various research areas including drug discovery, neurosciences, agriculture, food and nutrition, and environmental sciences.

MCE owns a unique collection of 981 human endogenous metabolites, all of which are derived from human issues. This library is a powerful tool for metabonomics research and metabolism-related drug discovery.

Cat. No.	Product Name	Type