Search Result

Results for "

nontoxic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Amyloid-β (9) Antibiotic (3) Apoptosis (5) Aryl Hydrocarbon Receptor (1) Atg4 (1) Autophagy (2) Bacterial (11) BCRP (1) Biochemical Assay Reagents (11) Caspase (2) Cathepsin (1) Cholinesterase (ChE) (3) CMV (1) CRISPR/Cas9 (1) Dengue virus (2) Dynamin (1) Elastase (1) Endogenous Metabolite (4) FGFR (1) Flavivirus (2) Fluorescent Dye (12) Fungal (5) Glucocorticoid Receptor (1) Glucosidase (2) Glutathione Peroxidase (1) HCV Protease (1) HSP (1) IGF-1R (1) iGluR (1) IRE1 (1) Isotope-Labeled Compounds (3) Lactate Dehydrogenase (2) Liposome (3) LPL Receptor (1) MALT1 (1) Microtubule/Tubulin (1) nAChR (1) Necroptosis (1) NF-κB (3) P-glycoprotein (1) Parasite (3) PDGFR (1) Reactive Oxygen Species (7) SARS-CoV (3) STAT (1) Tau Protein (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (3) Infection (23) Inflammation/Immunology (13) Metabolic Disease (13) Neurological Disease (22)
Oligonucleotides:	Fillers (1) Disintegrants (1) Emulsifiers (2) Cationic Lipids (2) Phospholipids (1) Solubilizing Agents (1)

106

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D1416

HMBR	Fluorescent Dye	Others
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-145296

Triflumezopyrim	nAChR	Infection
Triflumezopyrim, a mesoionic insecticide, has high efficiency at a low dosage, and is mainly used to control hopper species. Triflumezopyrim mainly acts on the nicotinic acetylcholine receptor (nAChR) inhibition, which is very highly efficient, rapidly effective, and nearly nontoxic to nontarget arthropods .

HY-W014394

Vanillyl butyl ether	Others	Cardiovascular Disease
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation .

HY-16663

ITX3 2 Publications Verification	Others	Others
ITX3 is a specific and nontoxic inhibitor of TrioN (N-terminal GEF domain of the multidomain Trio protein) with an IC₅₀ value of 76 μM. ITX3 can be used for the research of agent .

HY-W013435

1,2-Diaminoanthraquinone	Fluorescent Dye	Others
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .

HY-N10426

(+)-Cembrene A	Glucosidase	Metabolic Disease
(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-N10190

Asperaculane B	Parasite Endogenous Metabolite	Infection
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC₅₀ of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC₅₀ of 3 µM, and it is nontoxic to human cells .

HY-146686

BuChE-IN-3	Cholinesterase (ChE)	Neurological Disease
BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE with an IC₅₀ of 8.3 nM. BuChE-IN-3 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .

HY-146687

BuChE-IN-4	Cholinesterase (ChE)	Neurological Disease
BuChE-IN-4 (Compound C6) is a potent inhibitor of BuChE with an IC₅₀ of 7.7 nM. BuChE-IN-4 exhibits mild antioxidant capacity, nontoxicity, lipophilicity and neuroprotective activity .

HY-N1446A

Glycerol Monoleate	Endogenous Metabolite	Others
Glycerol Monoleate is a nontoxic, biodegradable and biocompatible, lipophilic glycerol fatty acid ester. Glycerol monooleate has hemolytic properties. glycerol monooleate is used as an emulsifier and an absorption enhancer in combination with bile salts. Glycerol Monoleate can be used in drug delivery systems and siRNA delivery in Vitro .

HY-107553

Chetomin	HSP Apoptosis	Cancer
Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule .

HY-145276

SARS-CoV-2-IN-10	SARS-CoV	Infection
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145277

SARS-CoV-2-IN-11	SARS-CoV	Infection
SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145080

Dynole 2−24	Dynamin	Neurological Disease
Dynole 2−24 is an indole-based dynamin GTPase inhibitor (IC₅₀=0.56 μM for dynamin I). Dynole 2−24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC_₅₀(CME)=1.9 μM). Dynole 2−24 also shows 4.4-fold selectivity for dynamin I. Dynole 2−24 is active in-cell inhibitor of clathrin-mediated endocytosis . CME: Clathrin mediated endocytosis

HY-100242

Mivotilate YH439	Aryl Hydrocarbon Receptor	Others
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.

HY-111761

DIQ3	Others	Cancer
DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines .

HY-151888

Anticancer agent 92	Others	Cancer
Anticancer agent 92 (Compound 5f) is an anticancer agent that is nontoxic against noncancerous cells .

HY-W143890

Etifenin EHIDA	Biochemical Assay Reagents	Neurological Disease Metabolic Disease
Etifenin can be used for production of non-toxic radiopharmaceuticals which are in regular radiodiagnostic use .

HY-101744

Ipsalazide	Autophagy	Inflammation/Immunology
Ipsalazide is a novel sulfasalazine analog designed to release 5-aminosalicylic acid and a nontoxic carrier molecule in the gastrointestinal tract.

HY-N3373

Loganetin	Bacterial	Infection
Loganetin is a non-toxic natural product that may be applied in the antibacterial agent development for treating multidrug-resistant Gram negative infections.

HY-146070

Elastase-IN-1	Elastase	Inflammation/Immunology Cancer
Elastase-IN-1 (Compound Q11) is an elastase inhibitor with an IC₅₀ of 0.897 µM. Elastase-IN-1 is non-toxic .

HY-107643

Reversan CBLC4H10	P-glycoprotein	Cancer
Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor .

HY-138171

Lipid 5	Liposome	Others
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-161021

AC2 selective-IN-1	Adenylate Cyclase	Others
AC2 selective-IN-1 (compound 14) is a? potent (IC₅₀=4.45 μM), non-toxic, and selective mAC2 inhibitor .

HY-128370

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	CMV	Infection
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .

HY-132934

Ac32Az19 1 Publications Verification	BCRP	Cancer
Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC₅₀ value of 13 nM in the BCRP-overexpressed HEK293/R2 cells.

HY-P3307

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2	Tau Protein	Neurological Disease
Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ₄₂.

HY-146101

NMDA receptor antagonist 5	iGluR	Neurological Disease
NMDA receptor antagonist 5 (Compound 10e) is a potent, brain permeable and non-toxic NMDA receptor antagonist. NMDA receptor antagonist 5 can be used for neurological disorder research .

HY-164370

Hesperidin dihydrochalcone	Others	Infection
Hesperidin dihydrochalcone is a non-toxic, high-sweetness, low-calorie sweetener. Hesperidin dihydrochalcone has many biological activities such as anti-oxidation, protection of liver and kidney, bacteriostasis and improvement of gastrointestinal tract .

HY-U00291

Tauroxicum	Antibiotic	Infection
Tauroxicum can be used as a nontoxic, non-antimicrobial agent that can replace or supplement the use of antibiotics in the animal husbandry of livestock animals to increase health and general well-being, productivity, feed efficiency and weight gain.

HY-146427

Antifungal agent 29	Fungal	Infection
Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM) .

HY-W010860

Copper(II) Gluconate	Others	Others
Copper(II) Gluconate is a non-toxic copper supplement aid. Copper(II) Gluconate is the copper salt of D-gluconic acid. Copper(II) Gluconate as a precursor catalyst that can be used in the photo-induced polymerisation of acrylates .

HY-125170

Galiellalactone	STAT	Cancer
Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC₅₀ of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer .

HY-N5060

Estragole 4-Allylanisole	Parasite	Neurological Disease
Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-P3417

Amp1EP9	Bacterial	Infection
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial agents. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections .

HY-125870

Gellan gum, for cell culture Agar substitute gelling agent, for cell culture	Biochemical Assay Reagents	Inflammation/Immunology
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .

HY-136251

BRD0539	CRISPR/Cas9	Infection
BRD0539 is a cell-permeable and non-toxic inhibitor of CRISPR-Cas9. BRD0539 inhibits Streptococcus pyogenes Cas9 (SpCas9) (apparent IC₅₀=22 μM) in an in vitro DNA cleavage assay .

HY-D0261

Tiron	Biochemical Assay Reagents Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .

HY-145830

AC1-IN-1	Adenylate Cyclase	Neurological Disease
AC1-IN-1 is a potent and selective Adenylyl cyclase type 1 (AC1) inhibitor with an IC₅₀ of 0.54 µM. AC1-IN-1 displays modest antiallodynic effects in a mouse model of inflammatory pain. AC1-IN-1 has CNS activity .

HY-112711

LV-320	Atg4 Autophagy Cathepsin	Cancer
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC₅₀ of 24.5 µM and a K_d of 16 µM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo .

HY-N7393

Isomalt Palatinitol	Lactate Dehydrogenase	Metabolic Disease
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N6595

Lucidone A	Others	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

HY-P10578

SEN 304	Amyloid-β	Neurological Disease
SEN 304 is an Aβ aggregation inhibitor. SEN 304 can bind directly to Aβ(1-42), delay β-sheet formation and promote aggregation of toxic oligomers into a nontoxic form. SEN 304 can be used for research of Alzheimer’s disease .

HY-B2144A

Chitosan (MW 150000) 2 Publications Verification Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000)	Bacterial Fungal	Infection Cancer
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .

HY-B2144B

Chitosan (MW 30000) 1 Publications Verification Deacetylated chitin (MW 30000); Poly(D-glucosamine) (MW 30000)	Bacterial Fungal	Infection Cancer
Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .

HY-141613

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium DOPS-NA	Liposome	Others
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-D1623

Cyanine3 carboxylic acid chloride	Fluorescent Dye	Others
Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions .

HY-Y0836S1

Diethyl succinate-d4 Diethyl Butanedioate-d₄	Isotope-Labeled Compounds	Metabolic Disease
Diethyl succinate-d₄ is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-N5060R

Estragole (Standard)	Parasite	Neurological Disease
Estragole (Standard) is the analytical standard of Estragole. This product is intended for research and analytical applications. Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-135747

Gut restricted-7 2 Publications Verification GR-7	Bacterial	Infection
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice .

Cat. No.	Product Name

HY-L167

Boronic Acid Compound Library

146 compounds

Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.

MCE designs a unique collection of 146 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Cat. No.	Product Name	Type

HY-D1416

HMBR	Fluorescent Dyes/Probes
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-W013435

1,2-Diaminoanthraquinone	Fluorescent Dyes/Probes
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .

HY-15930

TMB

1 Publications Verification

BM blue; Sure Blue TMB

Chromogenic Substrates

TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-15930A

TMB dihydrochloride

1 Publications Verification

BM blue dihydrochloride; Sure Blue TMB dihydrochloride

Chromogenic Substrates

TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-15930C

TMB monosulfate

1 Publications Verification

BM blue monosulfate; Sure Blue TMB monosulfate

Chromogenic Substrates

TMB monosulfate is the monosulfate form of TMB (HY-15930). TMB monosulfate is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB monosulfate can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB monosulfate can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-D1297

ER-Tracker Green

Fluorescent Dyes/Probes

ER-Tracker dye is a derivative of BODIPY series dyes coupled with Glibenclamide (HY-15206), highly selective binding to the endoplasmic reticulum, non-toxic to cells at low concentrations, this type of dye is an environmentally sensitive probe, and formaldehyde treatment can still retain part of the fluorescence, with high fluorescence life, good extinction coefficient and other characteristics. Glibenclamide is an atp-dependent K ⁺ channel blocker (Kir6, KATP) and CFTR Cl-channel blocker that binds in the endoplasmic reticulum. ER-Tracker is not suitable for staining cells after fixation .

HY-D1429

ER-Tracker Blue-White DPX

Fluorescent Dyes/Probes

HY-W923198

Fluorescein O-methacrylate Methacryloyloxy fluorescein	Fluorescent Dyes/Probes
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-sensitive dye featuring a fluorescent monomer, characterized by an excitation spectrum at 490 nm and an emission spectrum at 520 nm. With fluorescein serving as an indicator that possesses minimal negative charges, it exhibits properties such as biocompatibility, non-toxicity, and excellent dispersion in aqueous solutions.

HY-D1623

Cyanine3 carboxylic acid chloride	Fluorescent Dyes/Probes
Cyanine3 carboxylic acid chloride is a non-toxic red fluorescent dye with good solubility in organic solvents. Cyanine3 carboxylic acid chloride can be used as a non-reactive fluorophore for experimental control and calibration. Cyanine3 carboxylic acid chloride can also be synthesized with targeted agents as fluorescent probes for rapid detection of agent reactions .

HY-118540

Resazurin

Diazoresorcinol

Fluorescent Dyes/Probes

Resazurin (Diazoresorcinol) is a water-soluble, non-toxic, stable, membrane-permeable blue non-fluorescent dye (faintly fluorescent). Resazurin is used as a redox indicator, can be reduced to pink, highly fluorescent Resorufin (Ex=530-560 nm, Em=590 nm) in living cells. Resazurin can be used for the detection of cell viability, toxicity, proliferation, migration and invasion in cells (human, plant and animal, bacterial and fungal) .

HY-15930R

TMB (Standard)

Chromogenic Substrates

TMB (Standard) is the analytical standard of TMB. This product is intended for research and analytical applications. TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-D1431

ER-Tracker Red

1 Publications Verification

Fluorescent Dyes/Probes

Cat. No.	Product Name	Type

HY-138171

Lipid 5	Drug Delivery
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-125870

Gellan gum, for cell culture Agar substitute gelling agent, for cell culture	Thickeners
Gellan gum is a linear microbial exopolysaccharide that can be used as a cell scaffold for both soft tissue and load bearing applications. Gellan gum has many advantages such as biocompatibility, biodegradability, nontoxic in nature, and physical stability in the presence of cations .

HY-141613

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium DOPS-NA	Drug Delivery
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-W130177

Iodocholine iodide	Biochemical Assay Reagents
Iodocholine iodide is a non-toxic, metabolizable "green" catalyst that can catalyze the free radical polymerization of functional polymers. Iodocholine iodide is also the non-radioactive iodide of Carbon-11 choline. C-11 Choline can be used in PET imaging and non-informative bone scintigraphy, CT or MRI to monitor various types of cancer .

HY-Y1365

Gelatins

Thickeners

Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy ^[1][2][3].

HY-112758

DLin-KC2-DMA 4 Publications Verification	Drug Delivery
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-D1005

Poloxamer 407 (F127) 2 Publications Verification PEG-PPG-PEG, 12600 (Average Mn)	Co-solvents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8? AM and Quest Rhod-4? AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .

HY-Y0850U

PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)	Drug Delivery
PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) (Polyvinyl alcohol (Mw 31000, 87-89% hydrolyzed, ～630 polymerization); Poly(Ethenol) (Mw 31000, 87-89% hydrolyzed, ～630 polymerization)) is a biocompatible, biodegradable, nontoxic and hydrophilic synthetic polymer. PVA (Mw 31000, 87-89% hydrolyzed, ～630 polymerization) can be used to produce bone tissue engineering scaffold ^[1]

HY-159063

Soy Polysaccharides

Carbohydrates

Soy Polysaccharides are biochemical reagents that can be added to beverages, sauces, and dairy products as thickeners, emulsifiers, and dietary fiber ingredients. Soy Polysaccharides are non-toxic, hydrophilic, and biodegradable, allowing for widespread application in various food sectors. Additionally, Soy Polysaccharides serve as effective stabilizers in oil/water emulsions. Even under acidic conditions, Soy Polysaccharides can stabilize β-conglycinin-based emulsions to prevent flocculation .

HY-15930B

TMB dihydrochloride x.hydrate

Sure Blue TMB dihydrochloride x.hydrate

Enzyme Substrates

TMB (dihydrochloride x.hydrate) is the dihydrochloride x hydrate form of TMB (HY-15930). TMB (dihydrochloride x.hydrate) is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB (dihydrochloride x.hydrate) can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB (dihydrochloride x.hydrate) can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 .

HY-W250127

Disodium terephthalate

Terephthalic acid disodium salt

Buffer Reagents

Disodium terephthalate belongs to the class of organic salts. It is commonly used as a catalyst or intermediate in the production of a variety of industrial and consumer products, including polyethylene terephthalate (PET) plastics, polyester fibers and films. Disodium terephthalate has excellent thermal stability, chemical resistance and mechanical properties, making it ideal for high performance applications. Additionally, it is non-toxic, non-flammable and environmentally friendly, making it an attractive alternative to other petroleum-based chemicals. In the food and pharmaceutical industries, Disodium terephthalate is used as a pH regulator and buffer. It is generally considered safe for use in food and pharmaceutical applications by regulatory agencies such as the FDA.

HY-P3394

Cholera toxin B subunit, from vibrio cholerae

CTB, from vibrio cholerae

Native Proteins

Cholera toxin B subunit, from vibrio cholerae (CTB, from vibrio cholerae) is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. Cholera toxin B subunit, from vibrio cholerae attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. Cholera toxin B subunit, from vibrio cholerae has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Cholera toxin B subunit, from vibrio cholerae has been widely used as a marker of membrane lipid rafts .

Cat. No.	Product Name	Target	Research Area

HY-P0033

Argireline Acetyl hexapeptide-3	Peptides	Neurological Disease
Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity .

HY-P5361

β-Amyloid (40-1)	Peptides	Others
β-Amyloid (40-1) is a biological active peptide. (non-toxic reverse fragment Aβ(40–1), control of HY-P0265)

HY-P3307

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2	Tau Protein	Neurological Disease
Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 is serum stable, non-toxic to neuronal cells, and selectivity inhibits the fibrilization of tau over Aβ₄₂.

HY-P3417

Amp1EP9	Bacterial	Infection
Amp1EP9 is an antimicrobial peptide. Amp1EP9 is a powerful tool for developing potent and nontoxic antimicrobial agents. Amp1EP9 has the potential for the research of multidrug-resistant bacterial infections .

HY-P10560

M918	Peptides	Others
M918 is a cell-penetrating peptide. M918 is internalized by cells through endocytosis and can effectively penetrate a variety of cells in a non-toxic manner. M918 can be used in gene therapy and drug delivery system research .

HY-P0033A

Argireline acetate Acetyl hexapeptide-3 acetate	Peptides	Neurological Disease
Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca ²⁺ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity .

HY-P10578

SEN 304	Amyloid-β	Neurological Disease
SEN 304 is an Aβ aggregation inhibitor. SEN 304 can bind directly to Aβ(1-42), delay β-sheet formation and promote aggregation of toxic oligomers into a nontoxic form. SEN 304 can be used for research of Alzheimer’s disease .

HY-P4900

Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone	Caspase	Others
Fluorescein-6-carbonyl-Asp(OMe)-Glu(OMe)-Val-DL-Asp(OMe)-fluoromethylketone is a cell-permeable, non-toxic inhibitor that binds irreversibly to activated caspase-3 in apoptotic cells. The fluorescence intensity can be measured by flow cytometry, microwell plate reader, or fluorescence microscopy .

HY-P10546

Polyalanine peptide pALA	Bacterial	Infection
Polyalanine peptide (pALA) is an antimicrobial peptide that targets biofilms and Gram-negative bacteria and is non-toxic to mammalian cells. Polyalanine peptide forms an α-helical conformation that effectively permeabilizes Gram-negative bacterial membranes, thereby inducing lethal cell leakage. Polyalanine peptide can be used in anti-infection research .

HY-P5486

Tet-20	Bacterial	Others
Tet-20 is a biological active peptide. (Tet-20, is a synthetic cathelicidin-derived peptide. It was tested as infection-resistant coating for medical devices. When tethered on an implant surface Tet-20 exhibited broad antimicrobial activities both in vivo and in vitro. It can stop biofilm formation and appears to be non-toxic to eukaryotic cells)

HY-P1629

Temporin A	Bacterial Fungal Antibiotic	Infection
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .

HY-105066

Davunetide 1 Publications Verification	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Peptides	Cancer
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC₅₀ of 48.90 µg/mL .

Cat. No.	Product Name	Target	Research Area

HY-P99488

Briquilimab JSP-191	Inhibitory Antibodies	Inflammation/Immunology Cancer
Briquilimab (JSP-191) is a non-toxic humanized monoclonal antibody targeting CD117 (c-Kit) to deplete hematopoietic stem cell (HSC). Briquilimab has safety to clear host marrow niche space to enable sufficient donor HSC engraftment and immune reconstitution as primary method of severe combined immunodeficiency (SCID) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014394

Vanillyl butyl ether	Cardiovascular Disease Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Others
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether has been proposed as a mild warming agent providing a warming sensation and enhancing the blood circulation .

HY-N3373

Loganetin	Infection Structural Classification Human Gut Microbiota Metabolites Iridoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants Endogenous metabolite Disease Research Fields	Bacterial
Loganetin is a non-toxic natural product that may be applied in the antibacterial agent development for treating multidrug-resistant Gram negative infections.

HY-N5060

Estragole 4-Allylanisole	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Source classification Phenylpropanoids Plants Pandanaceae	Parasite
Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-N7393

Isomalt Palatinitol	other families Source classification Metabolic Disease Plants Disease Research Fields Saccharides	Lactate Dehydrogenase
Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-W010041

Scyllo-Inositol	Structural Classification Natural Products Source classification Endogenous metabolite	Amyloid-β Endogenous Metabolite
Scyllo-Inositol, an amyloid inhibitor, potentialy inhibits α-synuclein aggregation. Scyllo-Inositol stabilizes a non-fibrillar non-toxic form of amyloid-β peptide (Aβ42) in vitro, reverses cognitive deficits, and reduces synaptic toxicity and lowers amyloid plaques in an Alzheimer's disease mouse model .

HY-N10426

(+)-Cembrene A	Structural Classification Animals Terpenoids Source classification	Glucosidase
(+)-Cembrene A (Compound 5) is a α-glucosidase inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-N10190

Asperaculane B	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Endogenous metabolite Disease Research Fields	Parasite Endogenous Metabolite
Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC₅₀ of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC₅₀ of 3 µM, and it is nontoxic to human cells .

HY-N1446A

Glycerol Monoleate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Glycerol Monoleate is a nontoxic, biodegradable and biocompatible, lipophilic glycerol fatty acid ester. Glycerol monooleate has hemolytic properties. glycerol monooleate is used as an emulsifier and an absorption enhancer in combination with bile salts. Glycerol Monoleate can be used in drug delivery systems and siRNA delivery in Vitro .

HY-N6595

Lucidone A	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Lucidone A is a lanostanoid isolated from the fruiting bodies of G. resinaceum. lucidone A showed inhibitory effects against the increase of ALT and AST levels in HepG2 cells induced by H2O2 compared to a control group in the range of their maximum non-toxic concentration (MNTC) .

HY-N5060R

Estragole (Standard)	Structural Classification Pandanus amaryllifolius Roxb. Simple Phenylpropanols Source classification Phenylpropanoids Plants Pandanaceae	Parasite
Estragole (Standard) is the analytical standard of Estragole. This product is intended for research and analytical applications. Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

HY-P99488

Briquilimab JSP-191	Classification of Application Fields Disease Research Fields Cancer	Others
Briquilimab (JSP-191) is a non-toxic humanized monoclonal antibody targeting CD117 (c-Kit) to deplete hematopoietic stem cell (HSC). Briquilimab has safety to clear host marrow niche space to enable sufficient donor HSC engraftment and immune reconstitution as primary method of severe combined immunodeficiency (SCID) .

HY-14621

Zingerone 4 Publications Verification Vanillylacetone; Gingerone	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Zingiber officinale Roscoe Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Inflammation/Immunology Disease Research Fields Zingiberaceae	NF-κB
Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .

HY-N7393R

Isomalt (Standard)	other families Source classification Plants Saccharides	Lactate Dehydrogenase
Isomalt (Standard) is the analytical standard of Isomalt. This product is intended for research and analytical applications. Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes .

HY-N2132

Flavokawain B 1 Publications Verification Flavokavain B	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Cancer	Apoptosis
Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .

HY-N0626

Sorbic acid	Infection Structural Classification Microorganisms other families Preservatives Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite Disease Research Fields Food Research	Fungal Bacterial Endogenous Metabolite Antibiotic IGF-1R
Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways 。

HY-18979

Lactimidomycin 1 Publications Verification	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Flavivirus Dengue virus
Lactimidomycin is a glutarimide-containing compound isolated from Streptomyces. Lactimidomycin is a potent inhibitor of eukaryotic translation elongation. Lactimidomycin has a potent antiproliferative effect on tumor cell lines and selectively inhibit protein translation. Lactimidomycin inhibits protein synthesis with an IC₅₀ value of 37.82 nM. Lactimidomycin is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Anticancer and antiviral activities .

HY-14621R

Zingerone (Standard)	Zingiber officinale Roscoe Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Plants Zingiberaceae	NF-κB
Zingerone (Standard) is the analytical standard of Zingerone. This product is intended for research and analytical applications. Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale, with potent anti-inflammatory, antidiabetic, antilipolytic, antidiarrhoeic, antispasmodic and anti-tumor properties . Zingerone alleviates oxidative stress and inflammation, down-regulates NF-κB mediated signaling pathways . Zingerone acts as an anti-mitotic agent, and inhibits the growth of neuroblastoma cells .

HY-Y0836

Diethyl succinate 1 Publications Verification Diethyl Butanedioate	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Biochemical Assay Reagents Reactive Oxygen Species
Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-P1940

Maculosin Cyclo(Tyr-Pro)	Alkaloids Monophenols Microorganisms Pyrrole Alkaloids Source classification Phenols Disease Research Fields Cancer	Others
Maculosin is a host-specific phytotoxin for spotted knapweed from Alternaria alternata. Maculosin is a quorum-sensing molecule involved in cell-cell communication by Pseudomonas aeruginosa. Maculosin also acts as a signaling molecule regulating virulence gene expression in Lactobacillus reuteri. Maculosin shows antioxidant, anti-cancer and non-toxicity properties. Maculosin shows cytotoxic activity against the human liver cancer cell lines, with an IC₅₀ of 48.90 µg/mL .

HY-N2132R

Flavokawain B (Standard)	Structural Classification Chalcones Monophenols Flavonoids other families Source classification Phenols Plants	Apoptosis
Flavokawain B (Standard) is the analytical standard of Flavokawain B. This product is intended for research and analytical applications. Flavokawain B (Flavokavain B) is a chalcone isolated from the root extracts of kava-kava plant and a potent apoptosis inducer for inhibiting the growth of various cancer cell lines. Flavokawain B (Flavokavain B) shows strong antiangiogenic activity. Flavokawain B (Flavokavain B) inhibits human brain endothelial cell (HUVEC) migration and tube formation with very low and non-toxic concentrations .

HY-Y0836R

Diethyl succinate (Standard)	Structural Classification Natural Products Microorganisms other families Source classification Plants	Biochemical Assay Reagents Reactive Oxygen Species
Diethyl succinate (Standard) is the analytical standard of Diethyl succinate. This product is intended for research and analytical applications. Diethyl succinate (Diethyl Butanedioate) can be utilized at physiological pH, allowing it to penetrate biological membranes and integrate into the cells of tissue cultures, where it is metabolized via the tricarboxylic acid cycle. Diethyl succinate modulates the polarization and activation of microglial cells by reducing mitochondrial fission and the levels of reactive oxygen species (ROS), thereby exerting an inflammatory protective effect in primary microglial cells. Furthermore, Diethyl succinate is non-toxic and can be used in flavorings and seasonings .

HY-N7402

Hexyl hexanoate	Structural Classification Natural Products Animals Source classification	Others
Hexyl hexanoate is a fruit aroma component with potential food and beverage additive activity. Hexyl hexanoate is found in alcoholic beverages and is used to blend fruit flavors. Hexyl hexanoate is present in many fruits, Parmesan cheese, alcoholic beverages, and black tea. Hexyl hexanoate is a volatile component produced as a result of fruit ripening. Toxicity assessments of hexyl hexanoate showed that it is not mutagenic and that exposure is below safety thresholds for repeated dose, reproduction, and local respiratory toxicity. Hexyl hexanoate is also below thresholds in skin sensitization assessments, and for phototoxicity and photosensitization, the results showed that it does not present a relevant risk. Hexyl hexanoate is considered non-persistent, non-bioaccumulative, and non-toxic according to the environmental criteria of the International Fragrance Association .

Cat. No.	Product Name	Chemical Structure

HY-Y0836S

Diethyl succinate-13C4
Diethyl succinate- ¹³C₄ is the ¹³C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-Y0836S1

Diethyl succinate-d4
Diethyl succinate-d₄ is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].

HY-W013576S

Methyl 2-Octynoate-d5
Methyl 2-Octynoate-d₅ is deuterated labeled Estragole (HY-N5060). Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability . Estragole displays anti-toxoplasma activity .

Cat. No.	Product Name		Classification

HY-138171

Lipid 5		Cationic Lipids
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects .

HY-141613

1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium DOPS-NA		Phospholipids
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-Y1365

Gelatins		Emulsifiers Disintegrants
Gelatins is a non-toxic, non carcinogenic, biodegradable, and non irritating natural polymer derived from partial hydrolysis of collagen. Due to its strong liquid absorption and swelling ability, Gelatins has excellent hemostatic properties and can be used as a matrix material for the reduction, growth, and stability of metal nanoparticles. Gelatins can also be used for tumor cell culture and tumor therapy ^[1][2][3].

HY-112758

DLin-KC2-DMA 4 Publications Verification		Cationic Lipids
DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies .

HY-D1005

Poloxamer 407 (F127) 2 Publications Verification PEG-PPG-PEG, 12600 (Average Mn)		Emulsifiers Solubilizing Agents
Poloxamer 407 (F127) is a nonionic surfactant that is 100% active and relatively non-toxic to cells at low concentrations, and frequently used with dye AM esters such as Indo-1 AM, Fura-2 AM, Calcein AM, Fluo-3 AM, Fluo-4 AM, Quest Fluo-8? AM and Quest Rhod-4? AM, etc. to improve their water solubility. Poloxamer 407 is also a lipoprotein lipase inhibitor .

HY-W115746

Ethyl cellulose Ethyl cellulose N-200		Fillers
Ethyl cellulose is a derivative of cellulose. Ethyl cellulose serves as a non-toxic and biodegradable polymer, with unique properties such as oleogel formation, delivery of active component, and film-forming ability in the food and pharmaceutical sectors. Ethyl cellulose can be used as an excipient, such as coating agent, flavoring agent, tablet filler. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

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