Search Result
Results for "
omega-3
" in MedChemExpress (MCE) Product Catalog:
7
Biochemical Assay Reagents
7
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-125139
-
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ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%
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Biochemical Assay Reagents
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Cardiovascular Disease
Others
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omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
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- HY-P2959
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Fish oil from menhaden, crude source of omega-3 fatty acids
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Biochemical Assay Reagents
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Others
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Menhaden oil, crude source of omega-3 fatty acids is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-N12851
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(E)-4-Oxo-2-hexenal
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Bacterial
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Infection
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4-OHE ((E)-4-Oxo-2-hexenal) is a mutagen formed by the peroxidation of omega-3 fats. 4-OHE has antibacterial activity .
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- HY-B0660S
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- HY-120978
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ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester
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Biochemical Assay Reagents
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Others
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omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.
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- HY-154632
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Biochemical Assay Reagents
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Others
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Omega 3 fatty acid triglycerides can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-148944
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Reactive Oxygen Species
Apoptosis
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Cancer
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Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells .
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- HY-124089
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Cannabinoid Receptor
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Metabolic Disease
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Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant .
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- HY-125140
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Others
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Others
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ω-3 Arachidonic acid is a poly fatty acid that is essential for growth and development in infants. ω-3 Arachidonic acid inhibits arachidenol-CoA synthetase with Ki values of 14 µM. It also inhibited arachidenol-CoA synthetase of calf brain extract with IC50 values of about 5 µM .
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- HY-B0747S
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Endogenous Metabolite
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Metabolic Disease
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Eicosapentaenoic acid ethyl ester-d5 is the deuterium labeled Eicosapentaenoic acid ethyl ester. Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid agent.
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- HY-B2167
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- HY-115437
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- HY-B0747R
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EPA ethyl ester(Standard); Ethyl eicosapentaenoate (Standard); AMR101 (Standard)
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Endogenous Metabolite
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Metabolic Disease
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Eicosapentaenoic acid ethyl ester (Standard) is the analytical standard of Eicosapentaenoic acid ethyl ester. This product is intended for research and analytical applications. Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid agent.
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- HY-165078
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(±)11,12-EEQ; (±)11,12-Epoxyeicosatetraenoic acid
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Others
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Others
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(±)11(12)-EpETE ((±)11,12-EEQ) is an EPA hydroxyl product. EPA is a major component of Omega-3 polyunsaturated fatty acids (PUFAs) .
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- HY-B2167S
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DHA-d5; Cervonic acid-d5
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Endogenous Metabolite
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Neurological Disease
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Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
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- HY-N7833
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Biochemical Assay Reagents
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Others
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Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.
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- HY-W440983
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PC(18:0/22:6); DHA-PC; 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine
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PPAR
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Cardiovascular Disease
Cancer
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SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .
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- HY-B0660
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EPA; Timnodonic acid
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Endogenous Metabolite
Histone Demethylase
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Neurological Disease
Cancer
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Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation [3].
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- HY-W011269
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EPA sodium; Timnodonic acid sodium
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Endogenous Metabolite
Histone Demethylase
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Cardiovascular Disease
Metabolic Disease
Cancer
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Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation [3].
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- HY-125527
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RvD1
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Endogenous Metabolite
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Inflammation/Immunology
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Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .
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- HY-B0660A
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EPA (metformin); Timnodonic acid (metformin)
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Endogenous Metabolite
Histone Demethylase
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Neurological Disease
Cancer
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Eicosapentaenoic Acid (EPA) metformin is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic acid metformin exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). EEicosapentaenoic acid metformin activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic acid metformin can promote relaxation of vascular smooth muscle cells and vasodilation [3].
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- HY-125140S
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8(Z),11(Z),14(Z),17(Z)-Eicosatetraenoic-8,9,11,12,14,15,17,18-d8 acid
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Isotope-Labeled Compounds
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Others
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ω-3 Arachidonic Acid-d8 is the deuterium labeled ω-3 Arachidonic Acid[1].
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- HY-115369
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Biochemical Assay Reagents
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Others
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cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.
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- HY-B0660R
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Endogenous Metabolite
Histone Demethylase
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Neurological Disease
Cancer
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Eicosapentaenoic Acid (Standard) is the analytical standard of Eicosapentaenoic Acid. This product is intended for research and analytical applications. Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation [3].
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- HY-124089S
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Isotope-Labeled Compounds
Cannabinoid Receptor
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Metabolic Disease
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Eicosapentaenoyl ethanolamide-d4 is the deuterium labeled Eicosapentaenoyl ethanolamide. Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].
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- HY-125527S
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RvD1-d5
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Isotope-Labeled Compounds
Endogenous Metabolite
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Inflammation/Immunology
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Resolvin D1-d5 is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].
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- HY-120987
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Biochemical Assay Reagents
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Others
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6,9,12,15-octadecatetraenoic acid (Glycerol α-monoelaidate) is a rare omega-3 series polyunsaturated fatty acid. In normal people, it accounts for less than 0.25% of serum phospholipid fatty acids. It is found in certain natural oils, such as echium and blackcurrant, and to the extent that these oils are incorporated into nutraceuticals, stearidonic acid can be an important polyunsaturated species in the human diet. Ethyl stearidonic acid, an ester of the free acid, is less water soluble but more suitable for formulating stearidonic acid-containing diets and dietary supplements.
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- HY-125527R
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Endogenous Metabolite
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Inflammation/Immunology
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Resolvin D1 (Standard) is the analytical standard of Resolvin D1. This product is intended for research and analytical applications. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .
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- HY-114041
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RvE1
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Endogenous Metabolite
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Inflammation/Immunology
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Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production .
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- HY-113120
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6Z,9Z,12Z,15Z-Octadecatetraenoic acid
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Endogenous Metabolite
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Others
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Stearidonic acid (6Z,9Z,12Z,15Z-Octadecatetraenoic acid) is an intermediate fatty acid in the biosynthetic pathway from α-linolenic acid to VLC ω-3 PUFA. The conversion efficiency of stearidonic acid is higher than that of alpha-linolenic acid. Increasing the intake of stearidonic acid can increase the content of eicosapentaenoic acid (EPA) in red blood cells. Stearidonic acid can also be isolated from methanolic extracts of the brown alga Brachyphyllum gracilis .
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- HY-114041S1
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RvE1-d4-1
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Endogenous Metabolite
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Inflammation/Immunology
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Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
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- HY-B0747
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EPA ethyl ester; Ethyl eicosapentaenoate; AMR101
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Endogenous Metabolite
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Metabolic Disease
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Eicosapentaenoic acid ethyl ester (EPA ethyl ester) is an orally active ω-3 fatty acid agent. Eicosapentaenoic acid ethyl ester could improve the activity of liver β-oxidase in vitro, reduce the level of liver total triglyceride, increase the content of liver triglyceride and phospholipid ω-3 fatty acid, and increase the total ω-3 fatty acid level in rats [3].
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- HY-101408
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cis-13,16,19-docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid
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Endogenous Metabolite
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Cardiovascular Disease
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Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 μM.
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- HY-124355
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- HY-138969
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10,11-EDP-EA; 10,11-EDP epoxide; 10,11-Epoxy docosapentaenoic ethanolamide
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Others
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Others
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(±)10(11)-EDP ethanolamide (10,11-EDP-EA) (compound C) is an ω-3 endocannabinoid epoxide derivative with antiangiogenic, antitumor and anti-migratory properties in osteosarcoma models.
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- HY-B2167R
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Endogenous Metabolite
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Neurological Disease
Cancer
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Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC50 for RXRα activation by DHA is about 5-10 μM fatty acid [3].
In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .
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- HY-138970
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19,20-DHEA epoxide; 19,20-Epoxy docosapentaenoic acid ethanolamide; 19,20-EDP-EA
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Others
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Others
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(±)19(20)-EDP ethanolamide (19,20-DHEA epoxide) (compound 19) is an ω-3 endocannabinoid epoxide with cytokine modulation in neuroinflammation studies, antiangiogenic effects in vascular endothelial cells, and vasodilatory effects on coronary arteries.
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- HY-138971
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17,18-EEQ-EA; (±)17,18-EEQ-ethanolamide; (±)17(18)-EpETE-EA
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Others
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Others
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(±)17(18)-EpETE-ethanolamide (17,18-EEQ-EA) (compound 17) is an ω-3 endocannabinoid epoxide with cytokine modulation in neuroinflammation studies, antiangiogenic effects in vascular endothelial cells, and vasodilatory effects on coronary arteries.
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- HY-121212
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Others
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Metabolic Disease
Inflammation/Immunology
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Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis . Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent hypertriglyceridemia .
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- HY-115319
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Ferroptosis
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Inflammation/Immunology
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CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research .
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- HY-W747548
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Others
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Inflammation/Immunology
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12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.
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- HY-151245
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Others
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Cancer
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Neolinustatin is a cyanogenic glycoside that can be isolated from flaxseeds .
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- HY-118652
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ω-3 6-keto PGF2α
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Others
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Metabolic Disease
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Δ17-6-keto Prostaglandin F1α (Δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues. Δ17-6-keto PGF1α and other 3-series COX products from EPA, such as PGF3α, PGE3, and thromboxane B3, may be involved in the reduced incidence of glaucoma in patients on a marine-rich (EPA-rich) diet.
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- HY-113445
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COX
Endogenous Metabolite
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Endocrinology
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Thromboxane B3 is a prostaglandin analog derived from arachidonic acid (AA) in the cyclooxygenase (COX) metabolic pathway. Thromboxane B3 is generated from arachidonic acid (AA) in platelets and vascular endothelial cells through the catalysis of cyclooxygenase (COX) and thromboxane synthase (TXS). Thromboxane B3 has been reported to be formed by human platelets upon ingestion of eicosapentaenoic acid (C20: 5ω3) .
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| Cat. No. |
Product Name |
Type |
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- HY-125139
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ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%
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Drug Delivery
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omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
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- HY-P2959
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Fish oil from menhaden, crude source of omega-3 fatty acids
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Cell Assay Reagents
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Menhaden oil, crude source of omega-3 fatty acids is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-120978
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ω-3 Arachidonic acid methyl ester; (all-Z)-8,11,14,17-Eicosatetraenoic acid methyl ester
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Drug Delivery
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omega-3 Arachidonic Acid methyl ester, mainly docosahexaenoic acid, eicosapentaenoic acid and α-Linoleic acid, represented by linoleic acid, is an essential dietary nutrient required for normal growth and development.Omega-3Methyl arachidonic acid is a rare fatty acid Omega-3Neutral fat-soluble form of arachidonic acid. Omega-3Fatty acids, as a group, were associated with reduced inflammation and autoimmune activity, as well as reduced thrombosis and platelet activation.
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- HY-115437
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Drug Delivery
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Methyl all-cis-7,10,13,16,19-docosapentaenoate is a long-chain polyunsaturated omega-3 fatty acid esters.
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- HY-N7833
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Drug Delivery
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Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.
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- HY-115369
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Drug Delivery
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cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare omega-3 fatty acid not found in the normal phospholipid polyunsaturated fatty acid pool Easily detectable, it inhibits the binding of [3H]-LTB4 to porcine neutrophils at a concentration of 5 μM. Methyl docosatrienoate is more fat-soluble than the free acid and may be more desirable than the free acid in some formulations.
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- HY-120987
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Drug Delivery
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6,9,12,15-octadecatetraenoic acid (Glycerol α-monoelaidate) is a rare omega-3 series polyunsaturated fatty acid. In normal people, it accounts for less than 0.25% of serum phospholipid fatty acids. It is found in certain natural oils, such as echium and blackcurrant, and to the extent that these oils are incorporated into nutraceuticals, stearidonic acid can be an important polyunsaturated species in the human diet. Ethyl stearidonic acid, an ester of the free acid, is less water soluble but more suitable for formulating stearidonic acid-containing diets and dietary supplements.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
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- HY-N12851
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- HY-B2167
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- HY-B0660
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- HY-125527
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- HY-114041
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- HY-113120
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- HY-B0747
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- HY-W011269
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- HY-B0660R
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- HY-125527R
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Structural Classification
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
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Endogenous Metabolite
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Resolvin D1 (Standard) is the analytical standard of Resolvin D1. This product is intended for research and analytical applications. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages .
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- HY-101408
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- HY-B2167R
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Structural Classification
Human Gut Microbiota Metabolites
Microorganisms
Ketones, Aldehydes, Acids
Source classification
Disease markers
Endogenous metabolite
Cardiovascular System Disorder
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Endogenous Metabolite
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Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC50 for RXRα activation by DHA is about 5-10 μM fatty acid [3].
In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .
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- HY-151245
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Product Name |
Chemical Structure |
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- HY-B0660S
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Eicosapentaenoic Acid-d5 is the deuterium labeled Eicosapentaenoic Acid. Eicosapentaenoic Acid (EPA; Timnodonic acid) is an omega-3 fatty acid.
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- HY-B2167S
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Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
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- HY-124089S
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Eicosapentaenoyl ethanolamide-d4 is the deuterium labeled Eicosapentaenoyl ethanolamide. Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs). Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR)-induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].
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- HY-125527S
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Resolvin D1-d5 is the deuterium labeled Resolvin D1. Resolvin D1 (RvD1), an endogenous pro-resolving mediator of inflammation, is derived from omega-3 docosahexaenoic acid during the resolution phase of acute inflammation. Resolvin D1 blocks proinflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α–mediated inflammation in macrophages, and enhances phagocytosis of apoptotic cells by macrophages[1][2].
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- HY-B0747S
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Eicosapentaenoic acid ethyl ester-d5 is the deuterium labeled Eicosapentaenoic acid ethyl ester. Eicosapentaenoic acid ethyl ester is an omega-3 fatty acid agent.
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- HY-125140S
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ω-3 Arachidonic Acid-d8 is the deuterium labeled ω-3 Arachidonic Acid[1].
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- HY-114041S1
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Resolvin E1-d4-1 is the deuterium labeled Resolvin E1. Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production[1][2].
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| Cat. No. |
Product Name |
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Classification |
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- HY-17639
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RX-10045
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Alkynes
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Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Product Name |
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Classification |
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- HY-154632
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Others
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Omega 3 fatty acid triglycerides can be used as an excipient. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-W440983
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PC(18:0/22:6); DHA-PC; 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine
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Phospholipids
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SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .
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