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Results for "

pyrimidine derivative

" in MedChemExpress (MCE) Product Catalog:

51

Inhibitors & Agonists

1

Peptides

7

Natural
Products

15

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-I0960
    Uracil
    3 Publications Verification

    		 Endogenous Metabolite Drug Derivative Cancer
    Uracil is a pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA. Uracil is a frequently occurring DNA base damage that results from the spontaneous or chemically induced deamination of cytosine and is mutagenic at the level of replication. Uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins .
    Uracil
  • HY-Y0519
    Pyrimidine

    		Endogenous Metabolite Neurological Disease Cancer
    Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .
    Pyrimidine
  • HY-W027595
    N-Benzyl-6-chloropyrimidin-4-amine

    		Drug Derivative Others
    N-Benzyl-6-chloropyrimidin-4-amine is a pyrimidine derivative .
    N-Benzyl-6-chloropyrimidin-4-amine
  • HY-Y0519R
    Pyrimidine (Standard)

    		Endogenous Metabolite Metabolic Disease
    Pyrimidine (Standard) is the analytical standard of Pyrimidine. This product is intended for research and analytical applications. Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research .
    Pyrimidine (Standard)
  • HY-172003
    Isoorotidine

    		Nucleoside Antimetabolite/Analog Metabolic Disease
    Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).
    Isoorotidine
  • HY-151938
    Reverse transcriptase-IN-3

    		HIV Infection
    Reverse transcriptase-IN-3 is a pyrimidine-5-carboxamide derivative, acts as an inhibitor of HIV-1. Reverse transcriptase-IN-3 shows potent activity against the HIV-1 wild-type and mutant strains .
    Reverse transcriptase-IN-3
  • HY-116150
    Xymedon

    		Others Cardiovascular Disease
    Xymedon is a pyrimidine derivative with anti-atherosclerotic effects. Xymedon reducts plasma cholesterol levels and cholesterol esterification in blood vascular cells .
    Xymedon
  • HY-167828
    ARN25062

    		Ras Cancer
    ARN25062 (compound 27) is a CDC42/RHOJ inhibitor with antitumor activity. ARN25062 is a novel trisubstituted pyrimidine derivative .
    ARN25062
  • HY-157578
    COX-2-IN-38

    		COX Inflammation/Immunology
    COX-2-IN-38 (compound 52*) is a potent inhibitor of COX-2, with the IC50 value of 79.4 nM .
    COX-2-IN-38
  • HY-157583
    COX-2-IN-39

    		COX Others
    COX-2-IN-39 (compound 44) is a potent inhibitor of COX-2, with the IC50 value of 0.4 nM .
    COX-2-IN-39
  • HY-I0960R
    Uracil (Standard)

    		Endogenous Metabolite Cancer
    Uracil (Standard) is the analytical standard of Uracil. This product is intended for research and analytical applications. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil (Standard)
  • HY-I0960S7
    Uracil-d1

    		Endogenous Metabolite Cancer
    Uracil-d1 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d1
  • HY-I0960S9
    Uracil-d4

    		Endogenous Metabolite Cancer
    Uracil-d4 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d4
  • HY-I0960S2
    Uracil-13C

    		Endogenous Metabolite Cancer
    Uracil- 13C is the 13C labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-13C
  • HY-I0960S4
    Uracil-d2

    		Endogenous Metabolite Cancer
    Uracil-d2 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d2
  • HY-I0960S5
    Uracil-15N2

    		Endogenous Metabolite Cancer
    Uracil- 15N2 is the 15N labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-15N2
  • HY-I0960S8
    Uracil-d1-1

    		Endogenous Metabolite Cancer
    Uracil-d1-1 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d1-1
  • HY-I0960S1
    Uracil-13C4

    		Endogenous Metabolite Cancer
    Uracil- 13C4 is the 13C labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-13C4
  • HY-I0960S6
    Uracil-d2-1

    		Endogenous Metabolite Cancer
    Uracil-d2-1 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-d2-1
  • HY-I0960S
    Uracil-13C2,15N2

    		Endogenous Metabolite Cancer
    Uracil- 13C2, 15N2 is the 13C-labeled and 15N-labeled Uracil. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA.
    Uracil-13C2,15N2
  • HY-Y1298
    Methyl acetylacetate
    1 Publications Verification

    Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate

    		 Endogenous Metabolite Metabolic Disease Inflammation/Immunology
    Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives. Methyl acetoacetate can be used in the study of inflammatory diseases .
    Methyl acetylacetate
  • HY-I0960S3
    Uracil-13C4,15N2

    		Endogenous Metabolite Cancer
    Uracil- 13C4, 15N2 is the 13C and 15N labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
    Uracil-13C4,15N2
  • HY-139974
    BChE-IN-2

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-2 (compound 22) is a potent inhibitor of BChE with a Ki of 0.099 μM. BChE-IN-2 is a pyrimidine and pyridine derivative. BChE-IN-2 has the potential for the research of Alzheimer’s disease (AD) .
    BChE-IN-2
  • HY-Y1055A
    Guanine hydrochloride
    3 Publications Verification

    		 Endogenous Metabolite DNA/RNA Synthesis Others
    Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). It is a purine derivative composed of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity nitrogen reservoir .
    Guanine hydrochloride
  • HY-155761
    Antifungal agent 71

    		Fungal Infection
    Antifungal agent 71 (compound 6r) is a trifluoromethyl pyrimidine derivative with antifungal activity. Antifungal agent 71 exhibits good in vitro antifungal activity against F. oxysporum, with the EC50 value of 3.61 μg/mL .
    Antifungal agent 71
  • HY-148832
    BTK-IN-20

    		Btk Inflammation/Immunology Cancer
    BTK-IN-20 (compound 283) is a BTK tyrosine kinase inhibitor and a 1H-pyrazolo[3,4-d]pyrimidine derivative. BTK-IN-20 can be used for the research of cancer and inflammation .
    BTK-IN-20
  • HY-15645
    H4R antagonist 2

    		Histamine Receptor Inflammation/Immunology
    H4R antagonist 2 (page 68), a Furo[3,2-d]pyrimidine derivative, is a potent H4R antagonist. H4R antagonist 2 can be used in research of rheumatoid arthritis .
    H4R antagonist 2
  • HY-145554
    Bafrekalant

    		Drug Derivative Others
    Bafrekalant is a diazabicyclic substituted imidazo[l,2-a]pyrimidine-derivative. Bafrekalant has the potential for the research of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring (extracted from patent WO2018228907A1).
    Bafrekalant
  • HY-W049802
    N-((Allyloxy)carbonyl)-N-methyl-L-alanine

    		Complement System Inflammation/Immunology
    N-((Allyloxy)carbonyl)-N-methyl-L-alanine is a Alanine derivative. N-((Allyloxy)carbonyl)-N-methyl-L-alanine can be used for the synthesis of inhibitors of complement factor D. Complement factor D inhibitors can be used in the research of immune system related disease .
    N-((Allyloxy)carbonyl)-N-methyl-L-alanine
  • HY-Y1055S
    Guanine-13C

    		DNA/RNA Synthesis Endogenous Metabolite Cancer
    Guanine- 13C is the 13C labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
    Guanine-13C
  • HY-16398
    Pipobroman

    		DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .
    Pipobroman
  • HY-164151
    ERK-IN-8

    		ERK Cancer
    ERK-IN-8 (compound I-1) is an aniline pyrimidine derivative that acts as an ERK inhibitor. ERK-IN-8 has a strong inhibitory effect on ERK2 in vitro (IC50≤50 nM). ERK-IN-8 can be used in cancer research .
    ERK-IN-8
  • HY-Y1055S3
    Guanine-15N5

    		Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Others
    Guanine- 15N5 is 15N labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
    Guanine-15N5
  • HY-134772
    AS1810722

    		STAT Cytochrome P450 Inflammation/Immunology
    AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .
    AS1810722
  • HY-149365
    SIKs-IN-1

    		Salt-inducible Kinase (SIK) Inflammation/Immunology
    SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .
    SIKs-IN-1
  • HY-126297
    c-Fms-IN-10

    		c-Fms Inflammation/Immunology Cancer
    c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, an kinase inhibitor of FMS (Colony stimulating factor-1 receptor, CSF-1R) with IC50 of 2 nM. c-Fms-IN-10 has anti-tumor activity .
    c-Fms-IN-10
  • HY-130070
    QO-40

    		Potassium Channel Neurological Disease
    QO-40 is a pyrazolo[1,5-a]pyrimidine-7(4H)-one (PPO) derivative and an activator of the voltage-gated M-type potassium channel KCNQ encoded by the KCNQ2/3 gene (EC50: 1.25 μM) .
    QO-40
  • HY-Y1055S4
    Guanine-13C5

    		Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Others
    Guanine- 13C5 is 13C-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
    Guanine-13C5
  • HY-Y1055S1
    Guanine-13C,15N2

    		DNA/RNA Synthesis Endogenous Metabolite Cancer
    Guanine- 13C, 15N2 is the 13C and 15N labeled Guanine[1]. Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
    Guanine-13C,15N2
  • HY-Y1055
    Guanine
    3 Publications Verification

    		 DNA/RNA Synthesis Endogenous Metabolite Neurological Disease Cancer
    Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .
    Guanine
  • HY-Y1055R
    Guanine (Standard)

    		DNA/RNA Synthesis Endogenous Metabolite Cancer
    Guanine (Standard) is the analytical standard of Guanine. This product is intended for research and analytical applications. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool .
    Guanine (Standard)
  • HY-Y1055S2
    Guanine-13C5,15N5

    		Isotope-Labeled Compounds DNA/RNA Synthesis Endogenous Metabolite Cancer
    Guanine- 13C5, 15N5 is 13C and 15N-labeled Guanine (HY-Y1055). Guanine (2-Aminohypoxanthine) is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
    Guanine-13C5,15N5
  • HY-137265
    Aminomethyltrioxsalen hydrochloride

    		Biochemical Assay Reagents Others
    Aminomethyltrioxsalen hydrochloride is a derivative of Psoralen (HY-N0053). Aminomethyltrioxsalen hydrochloride penetrate intact cells and form interstrand crosslinks between pyrimidine residues of nucleic acid helices upon irradiation with ultraviolet light as a bifunctional nucleic acid intercalating agent, which can be used as a probe for double-stranded regions in heterogeneous nuclear RNA (hnRNA) to detect the secondary structure of hnRNA .
    Aminomethyltrioxsalen hydrochloride
  • HY-16182R
    Ecamsule (Standard)

    		Biochemical Assay Reagents Others
    Ecamsule (Standard) is the analytical standard of Ecamsule. This product is intended for research and analytical applications. Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
    Ecamsule (Standard)
  • HY-16182
    Ecamsule

    		Biochemical Assay Reagents Others
    Ecamsule is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression. Ecamsule has the potential for the research of polymorphous light eruption (PMLE) .
    Ecamsule
  • HY-16182A
    Ecamsule disodium

    		Biochemical Assay Reagents Others
    Ecamsule disodium is a broad-spectrum UVA filter that can be used in sunscreen product. Ecamsule reduces biological damage caused by solar radiation such as pyrimidine dimer formation, p53 protein accumula-tion, or collagenase 2 expression .
    Ecamsule disodium
  • HY-124719
    hSMG-1 inhibitor 11j
    3 Publications Verification

    		 PI3K mTOR GSK-3 CDK Cancer
    hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer .
    hSMG-1 inhibitor 11j
  • HY-161269
    EGFR-IN-101

    		EGFR Cancer
    EGFR-IN-101 (I-10) is a 2-phenylamino pyrimidine derivative. EGFR-IN-101 is a EGFR inhibitor. The IC50 values for EGFR L858R/T790M/C797S and Ba/F3-EGFR L858R/T790M/C797S are 33.26 and 106.4 nM, respectively. EGFR-IN-101 can be used IN the study of non-small cell lung cancer (NSCLC) .
    EGFR-IN-101
  • HY-147684
    FGFR-IN-7

    		FGFR Neurological Disease
    FGFR-IN-7 (compound 17) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-7 shows neuroprotective activity. FGFR-IN-7 improves brain exposure and reduced risk of phospholidosis. FGFR-IN-7 can be used for neurodegenerative diseases research .
    FGFR-IN-7
  • HY-147683
    FGFR-IN-3

    		FGFR Neurological Disease
    FGFR-IN-3 (compound 6) is an orally active, potent and BBB-penetrated FGFR (fibroblast growth factor receptor) modulator. FGFR-IN-3 shows neuroprotective activity. FGFR-IN-3 can be used for neurodegenerative diseases research .
    FGFR-IN-3