Search Result

Results for "

suppressive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Apoptosis (5) Aryl Hydrocarbon Receptor (1) Aurora Kinase (1) Autophagy (2) DNA/RNA Synthesis (2) Drug Metabolite (1) Epigenetic Reader Domain (1) Glucocorticoid Receptor (1) Insulin Receptor (1) Isotope-Labeled Compounds (1) Parasite (1) PI3K (1) Polo-like Kinase (PLK) (1) PTEN (1) Reactive Oxygen Species (2) STAT (1) Tyrosinase (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (6) Metabolic Disease (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0476

Wilforlide A Regelide; Abruslactone A	Others	Inflammation/Immunology
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .

HY-N6985

Baccatin III	Others	Cancer
Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs .

HY-151971

Aurora Kinases-IN-3	Aurora Kinase Polo-like Kinase (PLK)	Cancer
Aurora Kinases-IN-3 (Compound 15a) is an orally active AURKB inhibitor that elicits an AURKB-suppressive activity by disrupting the mitotic localization of AURKB, rather than inhibiting its phosphorylation of H3 at Ser10 .

HY-N5058

Dehydroeffusol	Apoptosis	Cancer
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity .

HY-B1214S

Prednisolone acetate-d8 Prednisolone 21-acetate-d₈	Isotope-Labeled Compounds Glucocorticoid Receptor	Inflammation/Immunology
Prednisolone acetate-d₈ is the deuterium labeled Prednisolone acetate. Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

HY-133672

(Rac)-Mono(3,5,5-trimethylhexyl) phthalate	Drug Metabolite	Inflammation/Immunology
(Rac)-Mono(3,5,5-trimethylhexyl) phthalate is a important metabolite of commonly used phthalate plasticizers. (Rac)-Mono(3,5,5-trimethylhexyl) phthalate has immuno-suppressive effect .

HY-139252

Anticancer agent 225	Reactive Oxygen Species	Cancer
Anticancer agent 225 (Comp 51) is a triterpenoic acids analogue which exhibits suppressive effect on elimination of different type of cancer stem cells (CSCs) and increase the ROS level of CSCs. Anticancer agent 225 can be used for cancer research .

HY-W145497

D-(+)-Sorbose	Insulin Receptor	Metabolic Disease
D-(+)-Sorbose, an active enantiomer of D-Sorbose, which inhibits disaccharidase activity and demonstrates suppressive action on postprandial blood levels of glucose and insulin in the rat. D-sorbose acts as a sweetener may contribute to the prevention of lifestyle-related diseases, such as type 2 diabetes mellitus .

HY-400705

Duocarmycin SA intermediate-1	Others	Cancer
Duocarmycin SA intermediate-1 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-1 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor-suppressive cytotoxicity with proton irradiation .

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Tyrosinase	Cancer
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant .

HY-148088

M1069	Adenosine Receptor	Cancer
M1069 is a selective and orall active, dual A_2A/A_2B adenosine receptor antagonist with a selectivity of >100 fold against the A₁ and A₃ receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .

HY-Y0152A

Cinchonine monohydrochloride hydrate (8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate	Parasite Apoptosis	Infection Cardiovascular Disease Metabolic Disease Cancer
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis .

HY-147918

Anticancer agent 73	DNA/RNA Synthesis	Cancer
Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo .

HY-148088A

M1069 free base	Adenosine Receptor	Cancer
M1069 (free base) is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 (free base) counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .

HY-150791

FLDP-5	Reactive Oxygen Species DNA/RNA Synthesis	Cancer
FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells .

HY-134463

NHWD-870 1 Publications Verification	Epigenetic Reader Domain Apoptosis	Cancer
NHWD-870 is a potent, orally active and selective BET family bromodomain inhibitor and only binds bromodomains of BRD2, BRD3, BRD4 (IC₅₀=2.7 nM), and BRDT. NHWD-870 has potent tumor suppressive efficacies and suppresses cancer cell-macrophage interaction. NHWD-870 increases tumor apoptosis and inhibits tumor proliferation .

HY-W338764

AHR agonist 3	Apoptosis Aryl Hydrocarbon Receptor	Cancer
AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research .

HY-146087

Autophagy inducer 4	Autophagy	Cancer
Autophagy inducer 4 is a Magnolol-based Mannich base derivatives, which can be used as an anticancer agent. Autophagy inducer 4 suppresses cancer cells via inducing autophagy. Autophagy inducer 4 has 76-fold improvement in cytotoxicity against T47D cells compared with Magnolol. Autophagy inducer 4 also possesses suppressive effects on migration of T47D and Hela cancer cells .

HY-N1435

Oroxin B 3 Publications Verification	Apoptosis PI3K PTEN Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

HY-160496

STAT3-IN-25	STAT	Cancer
STAT3-IN-25 (compound 4c) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-25 has luciferase activities IC₅₀ of 5.3 nM and ATP inhibition IC₅₀ of 4.2 nM.STAT3-IN-25 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 in the low nanomolar range by targeting the STAT3 SH2 domain (K_D=21.3 nM). STAT3-IN-25 exhibits significant suppressive effects in a pancreatic cancer xenograft model .

Cat. No.	Product Name	Target	Research Area

HY-P3865

Pancreastatin (33-49), porcine	Peptides	Metabolic Disease
Pancreastatin (33-49), porcine is a pancreastatin fragment. Pancreastatin is a peptide isolated from porcine pancreas which has insulin-suppressive actions in vitro. Pancreastatin (33-49), porcine enhances the priming effect of glucose .

HY-P3051

CKS-17	Peptides	Inflammation/Immunology
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions .

Cat. No.	Product Name	Target	Research Area

HY-P99327

Tregalizumab BT-061	Inhibitory Antibodies	Inflammation/Immunology
Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0476

Wilforlide A Regelide; Abruslactone A	Triterpenes Classification of Application Fields Terpenoids Source classification Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology	Others
Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .

HY-N6985

Baccatin III	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Others
Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs .

HY-N5058

Dehydroeffusol	Natural Products Juncus effusus Linn. Classification of Application Fields Juncaceae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity .

HY-N1775

3',4'-Dihydroxyacetophenone 3,4-DHAP	Structural Classification Classification of Application Fields Pinaceae Source classification Phenols Polyphenols Picea schrenkiana Fisch. et Mey. Plants Disease Research Fields Cancer	Tyrosinase
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC₅₀ of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant .

HY-Y0152A

Cinchonine monohydrochloride hydrate (8R,9S)-Cinchonine monohydrochloride hydrate; LA40221 monohydrochloride hydrate	Cardiovascular Disease Infection Cinchona succirubra Pav. ex Klotzsch Alkaloids Classification of Application Fields Source classification Rubiaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields	Parasite Apoptosis
Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural compound which has been effectively used as antimalarial agent. Cinchonine monohydrochloride hydrate activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Cinchonine monohydrochloride hydrate is also an inhibitor of human platelet aggregation. Cinchonine monohydrochloride hydrate possesses a suppressive effect on adipogenesis .

HY-N1435

Oroxin B 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Bignoniaceae Plants Oroxylum indicum (Linn.) Bentham ex Kurz Disease Research Fields Cancer	Apoptosis PI3K PTEN Autophagy
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT . Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .

Cat. No.	Product Name	Chemical Structure

HY-B1214S

Prednisolone acetate-d8
Prednisolone acetate-d₈ is the deuterium labeled Prednisolone acetate. Prednisolone acetate (Prednisolone 21-acetate) is an adrenal cortico hormones, with anti-inflammatory, anti-allergic and immune suppressive effects.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80777

	p38 Antibody MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB, IP	Human
	p38 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 41 kDa, targeting to p38. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P80776

	p38 Antibody (YA696) MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat, Monkey
	p38 Antibody (YA696) is a non-conjugated and Mouse origined monoclonal antibody about 41 kDa, targeting to p38 (5A1). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80842

	Phospho-p38 (Thr180/Tyr182) Antibody MAPK14; CSBP; CSBP1; CSBP2; CSPB1; MXI2; SAPK2A; Mitogen-activated protein kinase 14; MAP kinase 14; MAPK 14; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAP kinase MXI2; MAX-interacting protein	WB	Human, Mouse, Rat
	Phospho-p38 (Thr180/Tyr182) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 41 kDa, targeting to Phospho-p38 (Thr180/Tyr182). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80776A

	Phospho-p38 (Thr180+Tyr182) Antibody p38 (phospho T180 + Y182); p-p38 (phospho T180 + Y182); p38 (phospho T180/Y182); CSAID Binding Protein 1; CSAID binding protein; CSAID-binding protein; Csaids binding protein; CSBP 1; CSBP 2; CSBP; CSBP1; CSBP2; CSPB 1; CSPB1; Cytokine suppressive anti inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; EXIP; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAPK 14; MAPK14; MAX interacting protein 2; MAX-interacting protein 2; Mitogen Activated Protein Kinase 14; Mitogen activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MK14_HUMAN; Mxi 2; Mxi2; p38 ALPHA; p38; p38 MAP kinase; p38 MAPK; p38 mitogen activated protein kinase; p38ALPHA; p38alpha Exip; PRKM14; PRKM15; RK; SAPK 2A; SAPK2A; Stress Activated Protein Kinase 2A.	WB, IHC-P, FC, ICC/IF, ELISA	Human, Mouse
	Phospho-p38 (Thr180+Tyr182) Antibody is a rabbit-derived non-conjugated IgG antibody, targeting Phospho-p38 (Thr180+Tyr182), with a predicted molecular weight of 41 kDa (observed band size: ). Phospho-p38 (Thr180+Tyr182) Antibody can be used for WB, IHC-P, FC, ICC/IF, ELISA experiments in human, mouse backgrounds.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

suppressive

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products