2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK) ROS Kinase
  4. Iruplinalkib

Iruplinalkib  (Synonyms: WX-0593)

Cat. No.: HY-145574 Purity: 99.29%
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Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement.

For research use only. We do not sell to patients.

Iruplinalkib Chemical Structure

Iruplinalkib Chemical Structure

CAS No. : 1854943-32-0

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Based on 1 publication(s) in Google Scholar

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Description

Iruplinalkib (WX-0593) is a potent, selective, and orally active inhibitor of ALK and ROS1 tyrosine kinase. Iruplinalkib (WX-0593) shows favorable safety and promising antitumor activity in advanced NSCLC with ALK or ROS1 rearrangement[1].

IC50 & Target

ALK and ROS1[1]
Clinical Trial
Molecular Weight

569.08

Formula

C29H38ClN6O2P
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=P(C)(C)C1=C(NC2=NC(NC3=CC=C(N4CCC5(CCN(CC5)C)CC4)C=C3OC)=NC=C2Cl)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (17.57 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7572 mL 8.7861 mL 17.5722 mL
5 mM 0.3514 mL 1.7572 mL 3.5144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7572 mL 8.7861 mL 17.5722 mL 43.9306 mL
5 mM 0.3514 mL 1.7572 mL 3.5144 mL 8.7861 mL
10 mM 0.1757 mL 0.8786 mL 1.7572 mL 4.3931 mL
15 mM 0.1171 mL 0.5857 mL 1.1715 mL 2.9287 mL
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Iruplinalkib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Iruplinalkib1854943-32-0WX-0593WX0593WX 0593Anaplastic lymphoma kinase (ALK)ROS KinaseAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246oralALKROS1tyrosine kinaseNSCLCInhibitorinhibitorinhibit

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