2. PI3K/Akt/mTOR
  3. PI3K
  4. TG 100713

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively.

For research use only. We do not sell to patients.

TG 100713 Chemical Structure

TG 100713 Chemical Structure

CAS No. : 925705-73-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 77 In-stock
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Solid
5 mg USD 70 In-stock
10 mg USD 110 In-stock
50 mg USD 410 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

TG 100713 Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].

IC50 & Target[1]

PI3Kδ

24 nM (IC50)

PI3Kγ

50 nM (IC50)

PI3Kα

165 nM (IC50)

PI3Kβ

215 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.49 μM
Compound: TG100713
Anticancer activity against human A549 cells by MTT assay
Anticancer activity against human A549 cells by MTT assay
10.1039/C3MD00301A
HeLa IC50
0.15 μM
Compound: TG100713
Anticancer activity against human HeLa cells by MTT assay
Anticancer activity against human HeLa cells by MTT assay
10.1039/C3MD00301A
HepG2 IC50
0.82 μM
Compound: TG100713
Anticancer activity against human HepG2 cells by MTT assay
Anticancer activity against human HepG2 cells by MTT assay
10.1039/C3MD00301A
MCF7 IC50
1.03 μM
Compound: TG100713
Anticancer activity against human MCF7 cells by MTT assay
Anticancer activity against human MCF7 cells by MTT assay
10.1039/C3MD00301A
In Vitro

TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TG 100713 Related Antibodies
Molecular Weight

254.25

Formula

C12H10N6O
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

OC1=CC=CC(C2=NC3=C(N)N=C(N)N=C3N=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 6.41 mg/mL (25.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9331 mL 19.6657 mL 39.3314 mL
5 mM 0.7866 mL 3.9331 mL 7.8663 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.49%

SDS (393 KB)

COA (246 KB) HNMR (266 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9331 mL 19.6657 mL 39.3314 mL 98.3284 mL
5 mM 0.7866 mL 3.9331 mL 7.8663 mL 19.6657 mL
10 mM 0.3933 mL 1.9666 mL 3.9331 mL 9.8328 mL
15 mM 0.2622 mL 1.3110 mL 2.6221 mL 6.5552 mL
20 mM 0.1967 mL 0.9833 mL 1.9666 mL 4.9164 mL
25 mM 0.1573 mL 0.7866 mL 1.5733 mL 3.9331 mL
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TG 100713 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TG 100713925705-73-3TG100713TG-100713PI3KPhosphoinositide 3-kinasePI3KδPI3KγPI3KαPI3KβisoformInhibitorinhibitorinhibit

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