2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide 4'-ether-PEG1-azide

Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs.

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Thalidomide 4'-ether-PEG1-azide Chemical Structure

Thalidomide 4'-ether-PEG1-azide Chemical Structure

CAS No. : 2758432-02-7

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Thalidomide 4'-ether-PEG1-azide Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs[1].

Molecular Weight

387.35

Formula

C17H17N5O6
CAS No.
SMILES

[N-]=[N+]=NCCOCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Thalidomide 4'-ether-PEG1-azide Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide 4'-ether-PEG1-azide2758432-02-7Ligands for E3 LigaseE3 ligase-recruiting MoietyThalidomideCRBNPEGlinkercereblonInhibitorinhibitorinhibit

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