2. Apoptosis NF-κB
  3. TNF Receptor NF-κB
  4. TNF-α-IN-18

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis.

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TNF-α-IN-18 Chemical Structure

TNF-α-IN-18 Chemical Structure

CAS No. : 1272322-42-5

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Based on 1 publication(s) in Google Scholar

TNF-α-IN-18 Related Antibodies

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Description

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis[1].

Molecular Weight

336.67

Formula

C16H7ClF2O4
CAS No.
SMILES

O=C(C1=C(C2=C(F)C=CC(F)=C2)OC3=CC(Cl)=CC=C3C1=O)O
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TNF-α-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-181272322-42-5TNF ReceptorNF-κBTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBseptic lethality modelrheumatoid arthritisinflammatory bowel diseaseIBDacute kidney injuryCIA mouseBALB/c mouseC57BL/6 J mouseInhibitorinhibitorinhibit

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