2. Apoptosis NF-κB
  3. TNF Receptor NF-κB
  4. TNF-α-IN-18

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis.

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TNF-α-IN-18 Chemical Structure

TNF-α-IN-18 Chemical Structure

CAS No. : 1272322-42-5

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Based on 1 publication(s) in Google Scholar

TNF-α-IN-18 Related Antibodies

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Description

TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α (IC50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis[1].

Molecular Weight

336.67

Formula

C16H7ClF2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C2=C(F)C=CC(F)=C2)OC3=CC(Cl)=CC=C3C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (297.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9703 mL 14.8513 mL 29.7027 mL
5 mM 0.5941 mL 2.9703 mL 5.9405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9703 mL 14.8513 mL 29.7027 mL 74.2567 mL
5 mM 0.5941 mL 2.9703 mL 5.9405 mL 14.8513 mL
10 mM 0.2970 mL 1.4851 mL 2.9703 mL 7.4257 mL
15 mM 0.1980 mL 0.9901 mL 1.9802 mL 4.9504 mL
20 mM 0.1485 mL 0.7426 mL 1.4851 mL 3.7128 mL
25 mM 0.1188 mL 0.5941 mL 1.1881 mL 2.9703 mL
30 mM 0.0990 mL 0.4950 mL 0.9901 mL 2.4752 mL
40 mM 0.0743 mL 0.3713 mL 0.7426 mL 1.8564 mL
50 mM 0.0594 mL 0.2970 mL 0.5941 mL 1.4851 mL
60 mM 0.0495 mL 0.2475 mL 0.4950 mL 1.2376 mL
80 mM 0.0371 mL 0.1856 mL 0.3713 mL 0.9282 mL
100 mM 0.0297 mL 0.1485 mL 0.2970 mL 0.7426 mL
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TNF-α-IN-18 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-181272322-42-5TNF ReceptorNF-κBTumor Necrosis Factor ReceptorTNFRNuclear factor-κBNuclear factor-kappaBseptic lethality modelrheumatoid arthritisinflammatory bowel diseaseIBDacute kidney injuryCIA mouseBALB/c mouseC57BL/6 J mouseInhibitorinhibitorinhibit

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