2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Antibiotic Phospholipase
  4. Neomycin sulfate

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis.

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Neomycin sulfate Chemical Structure

Neomycin sulfate Chemical Structure

CAS No. : 1405-10-3

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10 mM * 1 mL in Water
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Based on 37 publication(s) in Google Scholar

Other Forms of Neomycin sulfate:

Neomycin sulfate Related Antibodies

Top Publications Citing Use of Products

37 Publications Citing Use of MCE Neomycin sulfate

View All Antibiotic Isoform Specific Products:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Phospholipase A PLD Phospholipase C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis[1][2].

IC50 & Target

Aminoglycoside

 

In Vitro

Neomycin is effective against most gram-negative organisms except Pseudomonas aeruginosa and anaerobic bacteria. Its activity against gram-positive microorganisms is more or less limited to staphylococci, but bacterial resistance supervenes after prolonged use[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neomycin sulfate Related Antibodies
Molecular Weight

908.88

Formula

C23H52N6O25S3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@H](O)[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)O[C@@H]1CN.[3H2SO4]
Structure Classification
Initial Source

Micromonospora species
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (275.06 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1003 mL 5.5013 mL 11.0026 mL
5 mM 0.2201 mL 1.1003 mL 2.2005 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (55.01 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.50%

SDS (419 KB)

COA (256 KB) HNMR (300 KB) RP-HPLC (204 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.1003 mL 5.5013 mL 11.0026 mL 27.5064 mL
5 mM 0.2201 mL 1.1003 mL 2.2005 mL 5.5013 mL
10 mM 0.1100 mL 0.5501 mL 1.1003 mL 2.7506 mL
15 mM 0.0734 mL 0.3668 mL 0.7335 mL 1.8338 mL
20 mM 0.0550 mL 0.2751 mL 0.5501 mL 1.3753 mL
25 mM 0.0440 mL 0.2201 mL 0.4401 mL 1.1003 mL
30 mM 0.0367 mL 0.1834 mL 0.3668 mL 0.9169 mL
40 mM 0.0275 mL 0.1375 mL 0.2751 mL 0.6877 mL
50 mM 0.0220 mL 0.1100 mL 0.2201 mL 0.5501 mL
60 mM 0.0183 mL 0.0917 mL 0.1834 mL 0.4584 mL
80 mM 0.0138 mL 0.0688 mL 0.1375 mL 0.3438 mL
100 mM 0.0110 mL 0.0550 mL 0.1100 mL 0.2751 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Neomycin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neomycin1405-10-3BacterialAntibioticPhospholipaseangiogeninproliferationaminoglycosideribosomalproteinsynthesisInhibitorinhibitorinhibit

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