Tributyl citrate

Cat. No.: HY-W013762 Purity: 98.33%: FAQs
Data Sheet SDS COA Handling Instructions

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Tributyl citrate is a citric acid ester. Tributyl citrate can be used as an excipient, such as plasticizer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.

For research use only. We do not sell to patients.

Tributyl citrate Chemical Structure

CAS No. : 77-94-1

Size	Price	Stock	Quantity
100 g	USD 29	In-stock	Estimated Time of Arrival: December 31
250 g	USD 58	In-stock	Estimated Time of Arrival: December 31
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Tributyl citrate:

Tributyl citrate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

360.45

Formula

C₁₈H₃₂O₇

CAS No.

77-94-1

Appearance

Liquid (Density: 1.080±0.06 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(CC(C(OCCCC)=O)(O)CC(OCCCC)=O)OCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (277.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7743 mL	13.8715 mL	27.7431 mL
5 mM	0.5549 mL	2.7743 mL	5.5486 mL
10 mM	0.2774 mL	1.3872 mL	2.7743 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 20% SBE-β-CD in Saline
Solubility: 40 mg/mL (110.97 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.33%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (244 KB) HNMR (244 KB) RP-HPLC (246 KB)

Handling Instructions (2659 KB)

References

[1]. FINKELSTEIN M, et al. Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate. Toxicol Appl Pharmacol. 1959 May;1(3):283-98. [Content Brief]

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7743 mL	13.8715 mL	27.7431 mL	69.3577 mL
	5 mM	0.5549 mL	2.7743 mL	5.5486 mL	13.8715 mL
	10 mM	0.2774 mL	1.3872 mL	2.7743 mL	6.9358 mL
	15 mM	0.1850 mL	0.9248 mL	1.8495 mL	4.6238 mL
	20 mM	0.1387 mL	0.6936 mL	1.3872 mL	3.4679 mL
	25 mM	0.1110 mL	0.5549 mL	1.1097 mL	2.7743 mL
	30 mM	0.0925 mL	0.4624 mL	0.9248 mL	2.3119 mL
	40 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.7339 mL
	50 mM	0.0555 mL	0.2774 mL	0.5549 mL	1.3872 mL
	60 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1560 mL
	80 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8670 mL
	100 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6936 mL