1. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  2. Monoamine Oxidase Reactive Oxygen Species NF-κB Interleukin Related TNF Receptor
  3. Triphenyl phosphate

Triphenyl phosphate is an organic phosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neurological behavior. Triphenyl phosphate promotes oxidative stress by inducing inflammatory factors like nuclear factor kappa B (NFκB), interleukin-6, and tumor necrosis factor α. Triphenyl phosphate can also cause allergic contact dermatitis.

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Triphenyl phosphate Chemical Structure

Triphenyl phosphate Chemical Structure

CAS No. : 115-86-6

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Description

Triphenyl phosphate is an organic phosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neurological behavior. Triphenyl phosphate promotes oxidative stress by inducing inflammatory factors like nuclear factor kappa B (NFκB), interleukin-6, and tumor necrosis factor α. Triphenyl phosphate can also cause allergic contact dermatitis[1][2].

IC50 & Target

IL-6

 

Molecular Weight

326.28

Formula

C18H15O4P

CAS No.
SMILES

O=P(OC1=CC=CC=C1)(OC2=CC=CC=C2)OC3=CC=CC=C3

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Triphenyl phosphate
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HY-Y1322
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