2. Vitamin D Related/Nuclear Receptor
  3. Thyroid Hormone Receptor
  4. VK-0214

VK-0214 is an agonist for thyroid beta receptor (TRβ), which ameliorates the X-linked adrenoleukodystrophy (X-ALD), through activation of ABCD2 expression and reduction of very long chain fatty acids (VLCFA) accumulation.

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VK-0214 Chemical Structure

VK-0214 Chemical Structure

CAS No. : 852949-30-5

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1 mg USD 240 In-stock
5 mg USD 600 In-stock
10 mg USD 960 In-stock
25 mg USD 1920 In-stock
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Based on 1 publication(s) in Google Scholar

VK-0214 Related Antibodies

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Description

VK-0214 is an agonist for thyroid beta receptor (TRβ), which ameliorates the X-linked adrenoleukodystrophy (X-ALD), through activation of ABCD2 expression and reduction of very long chain fatty acids (VLCFA) accumulation[1].

Molecular Weight

412.42

Formula

C23H25O5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(COC1=CC(C)=C(CC2=CC=C(C(CC3=CC=CC=C3)=C2)O)C(C)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (303.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4247 mL 12.1236 mL 24.2471 mL
5 mM 0.4849 mL 2.4247 mL 4.8494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4247 mL 12.1236 mL 24.2471 mL 60.6178 mL
5 mM 0.4849 mL 2.4247 mL 4.8494 mL 12.1236 mL
10 mM 0.2425 mL 1.2124 mL 2.4247 mL 6.0618 mL
15 mM 0.1616 mL 0.8082 mL 1.6165 mL 4.0412 mL
20 mM 0.1212 mL 0.6062 mL 1.2124 mL 3.0309 mL
25 mM 0.0970 mL 0.4849 mL 0.9699 mL 2.4247 mL
30 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0206 mL
40 mM 0.0606 mL 0.3031 mL 0.6062 mL 1.5154 mL
50 mM 0.0485 mL 0.2425 mL 0.4849 mL 1.2124 mL
60 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
80 mM 0.0303 mL 0.1515 mL 0.3031 mL 0.7577 mL
100 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6062 mL
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VK-0214 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VK-0214852949-30-5VK0214VK 0214Thyroid Hormone ReceptorTHRX-linked adrenoleukodystrophyGBMglioblastomaInhibitorinhibitorinhibit

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