YM928

Cat. No.: HY-118814: FAQs
Data Sheet Handling Instructions

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YM928 is an orally active and noncompetitive α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC₅₀ value of 2 μM. YM928 blocks AMPA-induced intracellular calcium influx with an IC₅₀ value of 3 μM and antagonizes AMPA-induced inward currents with an IC₅₀ value of 1 μM. YM928 is promising for research of neurological disorders.

For research use only. We do not sell to patients.

YM928 Chemical Structure

CAS No. : 190842-36-5

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AMPA Receptor NMDA Receptor Kainate Receptor

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Neuron	IC₅₀	2 μM Compound: 16i, YM928	Inhibition of kainate-induced neurotoxicity in primary rat hippocampal neurons after 24 hrs by LDH assay Inhibition of kainate-induced neurotoxicity in primary rat hippocampal neurons after 24 hrs by LDH assay	[PMID: 25792143]

Molecular Weight

303.77

Formula

C₁₄H₁₀ClN₃OS

CAS No.

190842-36-5

SMILES

O=C1N=C(SC2=NC=CC=C12)N(C)C3=CC=C(C=C3)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ohno K, et al. Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. J Pharmacol Exp Ther. 2003 Jul;306(1):66-72. [Content Brief]

YM928 Related Classifications

Neurological Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM928190842-36-5YM 928YM-928iGluRIonotropic glutamate receptorsorally activeAMPArat hippocampalcalcium influxneurological disordersInhibitorinhibitorinhibit

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