Z-Leu-Leu-Glu-AMC (Synonyms: Z-LLE-AMC)

Cat. No.: HY-123053 Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-Leu-Leu-Glu-AMC Chemical Structure

CAS No. : 348086-66-8

Size	Price	Stock	Quantity
1 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 735	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Description

Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome^[1]

Molecular Weight

664.75

Formula

C₃₅H₄₄N₄O₉

CAS No.

348086-66-8

Appearance

Solid

Color

White to off-white

Sequence

{Z}-Leu-Leu-Glu-{AMC}

Sequence Shortening

{Z}-LLE-{AMC}

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (150.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5043 mL	7.5216 mL	15.0433 mL
5 mM	0.3009 mL	1.5043 mL	3.0086 mL
10 mM	0.1504 mL	0.7522 mL	1.5043 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (250 KB) LCMS (88 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. McNaught KS, et al. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett. 2001 Jan 19;297(3):191-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5043 mL	7.5216 mL	15.0432 mL	37.6081 mL
	5 mM	0.3009 mL	1.5043 mL	3.0086 mL	7.5216 mL
	10 mM	0.1504 mL	0.7522 mL	1.5043 mL	3.7608 mL
	15 mM	0.1003 mL	0.5014 mL	1.0029 mL	2.5072 mL
	20 mM	0.0752 mL	0.3761 mL	0.7522 mL	1.8804 mL
	25 mM	0.0602 mL	0.3009 mL	0.6017 mL	1.5043 mL
	30 mM	0.0501 mL	0.2507 mL	0.5014 mL	1.2536 mL
	40 mM	0.0376 mL	0.1880 mL	0.3761 mL	0.9402 mL
	50 mM	0.0301 mL	0.1504 mL	0.3009 mL	0.7522 mL
	60 mM	0.0251 mL	0.1254 mL	0.2507 mL	0.6268 mL
	80 mM	0.0188 mL	0.0940 mL	0.1880 mL	0.4701 mL
	100 mM	0.0150 mL	0.0752 mL	0.1504 mL	0.3761 mL

Z-Leu-Leu-Glu-AMC Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Leu-Leu-Glu-AMC348086-66-8Z-LLE-AMCProteasome20S proteasomesubstratepostacidic-likeInhibitorinhibitorinhibit

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