Azathioprine-13C4 (Synonyms: BW 57-322-13C4)

Cat. No.: HY-B0256S1: Data Sheet Handling Instructions Technical Support

Azathioprine-13C4 (BW 57-322-13C4) is the 13C labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.

For research use only. We do not sell to patients.

Azathioprine-13C4 Chemical Structure

CAS No. : 1346600-71-2

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1 mg		Get quote	Estimated Time of Arrival: April 15

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Description

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00753103	University Hospital Birmingham NHS Foundation Trust	Wegener´s Granulomatosis\|Renal Limited Vasculitis\|Microscopic Polyangiitis	January 2003	Phase 2
NCT01817972	Gastroenterology Research of America\|UCB Pharma	Crohn´s Disease	March 2013	Phase 3
NCT01446211	Nordic Pharma SAS	Wegeners Granulomatosis	November 2011	Phase 3
NCT00052039	InterMune	Lung Disease\|Pulmonary Fibrosis	April 2002	Phase 3
NCT04469842	Vanderbilt University Medical Center\|Veloxis Pharmaceuticals	Lung Transplant; Complications	August 2023	Early Phase 1
NCT03250143	Postgraduate Institute of Medical Education and Research	Chronic Refractory Urticaria	December 6, 2016	Phase 1\|Phase 2
NCT01381432	GlaxoSmithKline	Liver Diseases	December 2004
NCT01941095	Hoffmann-La Roche	Rheumatoid Arthritis	November 20, 2013	Phase 3
NCT01056237	Zhi-Hong Liu, M.D.\|Nanjing University School of Medicine	Lupus Nephritis	February 2010	Not Applicable
NCT00461825	Poitiers University Hospital	Kidney Transplantation	July 1998	Phase 3
NCT03164473	Assistance Publique - Hôpitaux de Paris\|French Vasculitis Study Group	Eosinophilic Granulomatosis With Polyangiitis	March 7, 2018	Phase 3
NCT00400075	Hospices Civils de Lyon	Polyarteritis Nodosa\|Microscopic Polyangiitis	July 1996	Phase 4
NCT00774852	National Institute of Allergy and Infectious Diseases (NIAID)\|Immune Tolerance Network (ITN)	Lupus Nephritis\|Lupus Erythematosus, Systemic	November 2008	Phase 2
NCT02598596	Ampel BioSolutions, LLC\|IND 2 Results LLC	Gout	December 2015	Phase 2
NCT02929706	Sixth Affiliated Hospital, Sun Yat-sen University\|Sir Run Run Shaw Hospital	Thiopurine-induced Leukopenia	July 2016	Not Applicable
NCT00104299	National Institute of Allergy and Infectious Diseases (NIAID)\|Immune Tolerance Network (ITN)\|Genentech, Inc.	Vasculitis\|Wegener´s Granulomatosis\|Microscopic Polyangiitis	January 2005	Phase 2\|Phase 3
NCT00307645	Assistance Publique - Hôpitaux de Paris	ANCA Associated Systemic Vasculitis Including Wegener´s\|Granulomatosis and Microscopic Polyangiitis and\|Renal Limited Vasculitis	May 2003	Phase 3
NCT00866684	Charite University, Berlin, Germany	Kidney Transplantation\|Skin Cancer	January 2007	Phase 4
NCT00615173	Sun Yat-sen University	Kidney Diseases\|Lupus Nephritis\|Tacrolimus\|Induction Phase\|Maintenance Phase	July 2006	Phase 3
NCT01172002	RenJi Hospital\|Changhai Hospital\|Shanghai 10th People´s Hospital\|Shanghai Zhongshan Hospital\|The First Affiliated Hospital with Nanjing Medical University\|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School\|The First Affiliated Hospital of Soochow University\|Zhejiang University\|Second Affiliated Hospital, School of Medicine, Zhejiang University\|First Affiliated Hospital of Wenzhou Medical University\|Qilu Hospital of Shandong University\|AnHui ShengLi Hospital\|First Affiliated Hospital Bengbu Medical College\|The First Affiliated Hospital of Anhui Medical University	Nephritis\|Lupus	March 2010	Not Applicable
NCT05263505	Washington University School of Medicine\|Eli Lilly and Company	Mucous Membrane Pemphigoid\|Cicatrizing Conjunctivitis	February 21, 2022	Phase 2
NCT02425852	Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives	Ulcerative Colitis	December 2016	Phase 4
NCT03414502	University of Nebraska	Rheumatoid Arthritis	August 2007	Phase 3
NCT02247258	Universitaire Ziekenhuizen KU Leuven\|International organization for the study of inflammatory bowel disease (IOIBD)	Crohn Disease\|Recurrence\|Azathioprine\|Prevention	October 2005	Phase 2
NCT01235689	AbbVie (prior sponsor, Abbott)\|AbbVie	Crohn´s Disease	February 11, 2011	Phase 3
NCT05584228	Nantes University Hospital\|Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives	Crohn Disease	April 1, 2023	Not Applicable
NCT02645565	Jawaharlal Institute of Postgraduate Medical Education & Research	Lupus Nephritis	December 2015	Phase 4
NCT04654988	Medical University of Warsaw	Myocarditis\|Heart Failure\|Endomyocardial Biopsy\|Cardiomyopathies, Secondary\|Immunosuppression	May 1, 2022	Phase 4
NCT01559142	Children´s Memorial Health Institute, Poland	Crohn Disease	November 2008	Phase 3
NCT00525473	National Taiwan University Hospital	Azathioprine\|Thiopurine Methyltransferase\|Inosine Triphosphate Pyrophosphatase\|Genetic Polymorphism	February 2007
NCT01823042	Jinling Hospital, China	Crohn´s Disease	October 2012	Not Applicable
NCT04160325	Zhu Weiming\|Jinling Hospital, China	Crohn Disease	May 14, 2018	Not Applicable
NCT03185611	Sixth Affiliated Hospital, Sun Yat-sen University\|First Affiliated Hospital, Sun Yat-Sen University\|Peking Union Medical College Hospital\|Xijing Hospital\|Shanghai 10th People´s Hospital\|RenJi Hospital\|Sir Run Run Shaw Hospital	Crohn Disease	May 18, 2017	Phase 3
NCT00626197	Genentech, Inc.\|Roche Pharma AG	Lupus Nephritis\|Systemic Lupus Erythematosus	February 15, 2008	Phase 3
NCT04660539	Hoffmann-La Roche	Neuromyelitis Optica Spectrum Disorder	March 2, 2021	Phase 3
NCT00204022	Frédéric A. Houssiau, MD, PhD\|Université Catholique de Louvain	Lupus Nephritis	February 2001	Phase 3
NCT00976690	Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives	Crohn Disease	October 2002	Phase 3
NCT00128895	University Medical Center Groningen\|ZonMw: The Netherlands Organisation for Health Research and Development\|Dutch Arthritis Association\|Dutch Kidney Foundation	Vasculitis	June 2003	Phase 4
NCT02281799	Shaare Zedek Medical Center\|Sydney Children´s Hospitals Network\|Christchurch Hospital	Pancreatitis\|Inflammatory Bowel Diseases	March 2015	Phase 4
NCT04737343	Chinese SLE Treatment And Research Group\|Shanghai Zhongshan Hospital\|Affiliated Hospital of Jilin University, Changchun,China\|Second Affiliated Hospital of Nanchang University\|The First Affiliated Hospital of Anhui Medical University\|Beijing Shijitan Hospital, Capital Medical University\|The Affiliated Hospital of Inner Mongolia Medical University\|First Affiliated Hospital of Kunming Medical University\|Sichuan Province People´s Hospital\|Second Affiliated Hospital, School of Medicine, Zhejiang University	ANCA Associated Vasculitis\|Maintenance Therapy	June 30, 2021	Not Applicable
NCT05861297	Nahda University	Immune Thrombocytopenia Purpura	May 5, 2020	Phase 4
NCT00098111	Massachusetts General Hospital	Crohn´s Disease	April 2005	Phase 3
NCT00537316	Merck Sharp & Dohme LLC	Ulcerative Colitis	July 2007	Phase 3
NCT00656656	University of Luebeck	Pemphigus	January 2008	Phase 2
NCT03229746	Assiut University	Immune Thrombocytopenia	August 1, 2017	Phase 4
NCT05969730	Mazandaran University of Medical Sciences	Atopic Dermatitis	August 15, 2023	Not Applicable
NCT02994927	ChemoCentryx	ANCA-Associated Vasculitis	March 15, 2017	Phase 3
NCT00230035	National Institute of Allergy and Infectious Diseases (NIAID)	Systemic Lupus Erythematosus	September 2005	Phase 2
NCT00494741	Mario Negri Institute for Pharmacological Research\|Agenzia Italiana del Farmaco	Kidney Transplant	May 2007	Phase 4
NCT02498977	King´s College London\|King´s College Hospital NHS Trust\|National Institute for Health Research, United Kingdom	Transplantation, Liver	October 2015	Phase 4
NCT00321906	University of Chicago\|Astellas Pharma Inc\|Loyola University\|University of Florida\|University of Pennsylvania\|Baylor College of Medicine\|Ochsner Health System\|Columbia University\|University of Wisconsin, Madison	Delayed Graft Function\|Acute Graft Rejection	April 2002	Phase 4
NCT03791827	Xiqiang Dang\|The Children´s Hospital Affiliated to Suzhou University\|Shandong Provincial Hospital\|Guizhou Provincial People´s Hospital\|LanZhou University\|The First Affiliated Hospital of Inner Mongolia Medical College\|People´s Hospital of Zhangjiajie\|Puyang Oilfield General Hospital\|The First Affiliated Hospital of Anhui Medical University\|Guizhou Maternal and Child Health Care Hospital\|The Second Affiliated Hospital & Yuying Children´s Hospital of Wenzhou Medical University\|Shenzhen Children´s Hospital\|The Second Affiliated Hospital of Harbin Medical University\|Yichang Central People´s Hospital\|Xian Children´s Hospital\|Wuhan Children´s Hospital, Tongji Medical College, Huazhong University of Science & Technology\|The First People´s Hospital of Yunnan\|The First Affiliated Hospital of Xiamen University\|The First Affiliated Hospital of Xinxiang Medical College\|Shanxi Provincial Maternity and Children´s Hospital\|Liaocheng People´s Hospital\|Fujian Provincial Hospital\|First Affiliated Hospital of Guangxi Medical University\|Second Hospital of Lanzhou University\|Guangzhou First People´s Hospital\|The Second Hospital of Shandong University\|Children´s Hospital of Hebei Province\|Beijing Children´s Hospital\|Zhengzhou Children´s Hospital\|The Children´s Hospital of Chongqing Medical University\|Wuxi Women´s & Children´s Hospital\|The Children´s Hospital of Fudan University\|Shanghai Children´s Medical Center\|Qilu Children´s Hospital of Shandong University\|Second Xiangya Hospital of Central South University	Lupus Nephritis\|Children\|Steroid\|Immunosuppressive Treatment	December 1, 2018
NCT02949349	Genovate Biotechnology Co., Ltd.,	Lupus Nephritis	July 2015	Phase 2
NCT01727193	First Affiliated Hospital, Sun Yat-Sen University	Myasthenia Gravis	September 2012	Phase 3
NCT04761952	Sixth Affiliated Hospital, Sun Yat-sen University	Inflammatory Bowel Diseases\|Crohn Disease\|Polyunsaturated Acid Lipidosis	February 13, 2021	Not Applicable
NCT03151525	Istituto Clinico Humanitas\|Agenzia Italiana del Farmaco	Colitis, Ulcerative	May 8, 2017	Phase 4
NCT04882683	Shandong Qilu Stem Cells Engineering Co., Ltd.	Ulcerative Colitis	June 1, 2021	Not Applicable
NCT00425438	Hoffmann-La Roche	Lupus Nephritis	March 2007	Phase 3
NCT02413047	Indiana University	Inflammatory Bowel Disease\|Ulcerative Colitis\|Crohn´s Disease	May 2015	Not Applicable
NCT00695344	Fundacion Investigacion y Desarrollo	Cardiac Transplant	January 2006	Phase 4
NCT02177071	Groupe d´Etude Therapeutique des Affections Inflammatoires Digestives\|Saint-Louis Hospital, Paris, France	Crohn´s Disease	October 9, 2015	Phase 4
NCT01390766	GlaxoSmithKline	Liver Diseases	August 2002
NCT05349006	Hospices Civils de Lyon	Central Nervous System Inflammation\|MOG-IgG Associated Disease	January 1, 2023	Phase 3
NCT03370601	University Hospital, Lille	Inflammatory Bowel Diseases	January 3, 2017	Not Applicable
NCT01564823	Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa\|Effice Servicios Para la Investigacion S.L.	Crohn´s Disease	June 2012	Phase 3
NCT01880307	Erasmus Medical Center\|University of Roma La Sapienza\|Universitair Ziekenhuis Brussel	Crohn´s Disease	January 2013	Phase 4
NCT00608894	Veloxis Pharmaceuticals	Autoimmune Hepatitis	December 2007	Phase 2
NCT03930264	Nova Laboratories Limited\|Medicines Evaluation Unit Ltd\|Syne Qua Non Limited\|Alderley Analytical Ltd\|Black County Pathology Services\|Diamond Pharma Services Regulatory Affairs Consultancy\|Boyd Consultants	Therapeutic Equivalency	April 11, 2019	Phase 1
NCT00748644	Assistance Publique - Hôpitaux de Paris	Wegener Granulomatosis\|Microscopic Polyangiitis	October 2008	Phase 3
NCT05813860	Sixth Affiliated Hospital, Sun Yat-sen University	Crohn Disease\|Infliximab	April 30, 2023	Phase 4
NCT03449758	Sanofi\|Regeneron Pharmaceuticals	Rheumatoid Arthritis	March 5, 2018	Phase 4
NCT02852694	PIBD-Net\|European Commission	Crohn´s Disease	February 28, 2017	Phase 4
NCT03770663	Assistance Publique - Hôpitaux de Paris	Antisynthetase Syndrome (ASS)\|Interstitial Lung Disease	February 5, 2021	Phase 3
NCT01284725	Assistance Publique Hopitaux De Marseille	Nephritis of Lupus	January 2011	Phase 3
NCT02517684	Erasmus Medical Center\|ZonMw: The Netherlands Organisation for Health Research and Development\|Hospira, now a wholly owned subsidiary of Pfizer	Crohn´s Disease	April 2015	Phase 4
NCT03498703	Ain Shams University\|Capital Birth Center	Recurrent Implantation Failure\|In Vitro Fertilization\|Intracytoplsmic Sperm Injection	April 25, 2018	Phase 2
NCT01697267	Cambridge University Hospitals NHS Foundation Trust\|Arthritis Research UK\|Roche Pharma AG\|Genentech, Inc.\|University of Pennsylvania	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis\|Microscopic Polyangiitis\|Wegener Granulomatosis	April 2013	Phase 3
NCT00349674	Hospices Civils de Lyon	Systemic Wegener´s Granulomatosis	January 1999	Phase 3
NCT04773392	University of Southern California\|Veloxis Pharmaceuticals	Kidney Transplantation\|Kidney Transplant Rejection	November 23, 2021	Phase 4
NCT03101800	Hvidovre University Hospital\|Aalborg University Hospital\|Zealand University Hospital\|University of Copenhagen\|Odense University Hospital\|Aarhus University Hospital\|Viborg Regional Hospital\|Vejle Hospital\|Sydvestjysk Hospital Esbjerg	Colitis, Ulcerative\|Colitis Ulcerative Exacerbation	December 14, 2016	Phase 3
NCT00849368	University of Zurich	Inflammatory Bowel Disease	January 2009	Phase 1
NCT00626678	Tehran University of Medical Sciences	Pemphigus Vulgaris	January 2008	Phase 2
NCT02444728	Chinese SLE Treatment And Research Group\|Peking Union Medical College Hospital	Thrombocytopenia	July 2015	Phase 3
NCT02900443	Radboud University Medical Center\|Leiden University Medical Center	Autoimmune Hepatitis	January 2017	Phase 4
NCT03490539	Duke University\|Beth Israel Deaconess Medical Center\|Patient-Centered Outcomes Research Institute	Neurological Disorder\|Autoimmune Diseases	May 7, 2018
NCT02579733	Kyungpook National University Hospital\|Celltrion	Ulcerative Colitis	February 1, 2016	Phase 4
NCT00504244	Erasmus Medical Center\|Novartis Pharmaceuticals	Systemic Lupus Erythematosus	July 2007	Phase 3
NCT00741338	Genzyme, a Sanofi Company\|BioMarin+Genzyme LLC\|Sanofi	Mucopolysaccharidosis I	September 2008	Phase 1\|Phase 2
NCT00150891	University of Giessen\|Heidelberg University\|Astellas Pharma Inc\|Novartis\|Fresenius AG\|Hoffmann-La Roche\|Biotest	Renal Failure, Chronic	January 1998
NCT05237323	I.M. Sechenov First Moscow State Medical University	Lymphocytic Myocarditis (Disorder)\|Heart Failure\|Dilated Cardiomyopathy\|Cardiomyopathies\|Sudden Cardiac Death	October 1, 2020	Phase 3
NCT01663623	Human Genome Sciences Inc., a GSK Company\|GlaxoSmithKline	Vasculitis	March 20, 2013	Phase 3
NCT00984568	Merck Sharp & Dohme LLC	Colitis, Ulcerative	November 2009	Phase 3
NCT00647166	Assistance Publique - Hôpitaux de Paris	MPA\|PAN or EGPA With FFS=0\|At Diagnosis or Within the First 15 Days Following Initiation of Corticosteroids	May 2008	Phase 3
NCT00113503	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)\|Prometheus Laboratories	Crohn´s Disease	July 2005	Phase 2
NCT01015391	Jinling Hospital, China	Crohn´s Disease	November 2009	Not Applicable
NCT01112215	Hospital Universitari Vall d´Hebron Research Institute	Systemic Lupus Erythematosus	December 2009	Phase 4
NCT05896605	First Affiliated Hospital of Guangxi Medical University	NMO Spectrum Disorder\|Azathioprine Adverse Reaction	January 1, 2020	Phase 4
NCT02998827	Sixth Affiliated Hospital, Sun Yat-sen University	Crohn Disease	November 2016	Not Applicable
NCT04933292	Xiaoli Fan\|West China Hospital	Autoimmune Hepatitis\|Primary Biliary Cirrhosis	June 16, 2021	Phase 4
NCT02332356	Tokyo Medical and Dental University	Crohn Disease	September 2014	Phase 3
NCT00189397	All India Institute of Medical Sciences, New Delhi	Parthenium Dermatitis	February 2003	Not Applicable
NCT03350633	Tianjin Medical University General Hospital	Neuromyelitis Optica Spectrum Disorders\|Neuromyelitis Optica	November 1, 2017	Phase 2\|Phase 3
NCT01877746	St. Anne´s University Hospital Brno, Czech Republic	Inflammatory Cardiomyopathy	January 2013	Phase 3
NCT02463331	University of Sao Paulo General Hospital	Autoimmune Hepatitis	May 2003	Phase 4
NCT02936375	RenJi Hospital	Lupus Nephritis	September 7, 2017	Phase 2
NCT00268515	National Heart, Lung, and Blood Institute (NHLBI)	Lung Diseases	April 1998	Phase 2
NCT03393247	Sixth Affiliated Hospital, Sun Yat-sen University	Crohn Disease	June 1, 2017	Not Applicable
NCT00521950	ZonMw: The Netherlands Organisation for Health Research and Development\|Radboud University Medical Center	Inflammatory Bowel Diseases\|Crohn Disease\|Ulcerative Colitis	September 2007	Not Applicable
NCT00755859	A. Manzoni Hospital	IGA Nephropathy	May 1998	Phase 4
NCT00431119	University Hospital Muenster\|Hoffmann-La Roche	Bullous Pemphigoid	October 1997	Phase 2
NCT00768729	National Institute of Allergy and Infectious Diseases (NIAID)	Kidney Failure, Chronic\|Kidney Transplantation\|Immunosuppression	May 2009	Phase 1
NCT00377637	Hoffmann-La Roche\|Aspreva Pharmaceuticals	Lupus Nephritis	July 2005	Phase 3
NCT05965284	Chinese SLE Treatment And Research Group	ANCA-associated Vasculitis\|Maintenance Therapy	March 9, 2023	Phase 4
NCT00399399	Hospices Civils de Lyon	Churg-Strauss Syndrome	July 1996	Phase 4
NCT00946946	Dr. Falk Pharma GmbH	Crohn´s Disease	February 2002	Phase 3
NCT01802593	Prof. Arie Levine\|Wolfson Medical Center	Crohn´s Disease	February 2013	Phase 4
NCT01392833	A. Manzoni Hospital	IgA Nephropathy\|Chronic Kidney Disease	December 1999	Phase 3
NCT03580876	Védrines, Philippe, M.D.	Clinical Failure After Switch	July 23, 2018	Phase 4
NCT03026907	University Medical Center Groningen	Hand Eczema	May 2016	Phase 3
NCT00987116	Assistance Publique - Hôpitaux de Paris	Myasthenia Gravis	June 2009	Phase 4
NCT02939573	University of Pennsylvania\|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)\|National Center for Advancing Translational Sciences (NCATS)\|Office of Rare Diseases (ORD)	Primary Cutaneous Vasculitis\|Cutaneous Polyarteritis Nodosa\|IgA Vasculitis\|Henoch-Schönlein Purpura	January 1, 2017	Phase 2
NCT05545384	Assistance Publique - Hôpitaux de Paris\|Institut National de la Santé Et de la Recherche Médicale, France	Acute Demyelinating Syndrome	July 2023	Phase 2\|Phase 3
NCT03681652	Schneider Children´s Medical Center, Israel	Crohn Disease	February 11, 2019
NCT03002038	Isfahan University of Medical Sciences	Neuromyelitis Optica Spectrum Disorder	September 2015	Phase 2\|Phase 3

Molecular Weight

281.23

Formula

C₅¹³C₄H₇N₇O₂S

CAS No.

1346600-71-2

Unlabeled CAS

446-86-6

SMILES

O=[N+]([O-])[13C](N=[13CH]N1[13CH3])=[13C]1SC2=C3C(N=CN3)=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (276 KB) Handling Instructions (2659 KB)

References

[1]. Patel, A.A., R.A. Swerlick, and C.O. McCall, Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol, 2006. 55(3): p. 369-89. [Content Brief]

[2]. Maltzman, J.S. and G.A. Koretzky, Azathioprine: old drug, new actions. J Clin Invest, 2003. 111(8): p. 1122-4. [Content Brief]

[3]. Dubinsky, M.C., Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol, 2004. 2(9): p. 731-43. [Content Brief]

Azathioprine-13C4 Related Classifications

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Keywords:

Azathioprine-13C41346600-71-2BW 57-322-13C4Isotope-Labeled Compoundsstable isotopeAzathioprineInhibitorinhibitorinhibit

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