12β-Acetoxyganoderic Acid θ

Cat. No.: HY-N5153 Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

12β-Acetoxyganoderic Acid θ is a triterpenoid that can be isolated from G. lucidum.

For research use only. We do not sell to patients.

12β-Acetoxyganoderic Acid θ Chemical Structure

CAS No. : 2374206-90-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Description

12β-Acetoxyganoderic Acid θ is a triterpenoid that can be isolated from G. lucidum^[1].

Molecular Weight

572.69

Formula

C₃₂H₄₄O₉

CAS No.

2374206-90-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@]12[C@]([C@@H](C(C3=C1C(C[C@]4([H])[C@@]3(CC[C@@H](C4(C)C)O)C)=O)=O)OC(C)=O)([C@@](CC2=O)([H])[C@H](C)C[C@H](O)/C=C(C)/C(O)=O)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Ganoderma lucidum

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (174.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7461 mL	8.7307 mL	17.4615 mL
5 mM	0.3492 mL	1.7461 mL	3.4923 mL
10 mM	0.1746 mL	0.8731 mL	1.7461 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.37 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (254 KB) HNMR (284 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Wu YL, et al. Triterpenoids from Ganoderma lucidum and Their Potential Anti-inflammatory Effects. J Agric Food Chem. 2019 May 8;67(18):5147-5158. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7461 mL	8.7307 mL	17.4615 mL	43.6536 mL
	5 mM	0.3492 mL	1.7461 mL	3.4923 mL	8.7307 mL
	10 mM	0.1746 mL	0.8731 mL	1.7461 mL	4.3654 mL
	15 mM	0.1164 mL	0.5820 mL	1.1641 mL	2.9102 mL
	20 mM	0.0873 mL	0.4365 mL	0.8731 mL	2.1827 mL
	25 mM	0.0698 mL	0.3492 mL	0.6985 mL	1.7461 mL
	30 mM	0.0582 mL	0.2910 mL	0.5820 mL	1.4551 mL
	40 mM	0.0437 mL	0.2183 mL	0.4365 mL	1.0913 mL
	50 mM	0.0349 mL	0.1746 mL	0.3492 mL	0.8731 mL
	60 mM	0.0291 mL	0.1455 mL	0.2910 mL	0.7276 mL
	80 mM	0.0218 mL	0.1091 mL	0.2183 mL	0.5457 mL
	100 mM	0.0175 mL	0.0873 mL	0.1746 mL	0.4365 mL