2-Ketoglutaric acid-¹³C₂ (Synonyms: Alpha-Ketoglutaric acid-¹³C₂)

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2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

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2-Ketoglutaric acid-<sup>13</sup>C<sub>2</sub> Chemical Structure

2-Ketoglutaric acid-¹³C₂ Chemical Structure

CAS No. : 123953-28-6

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Description	2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid^[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM)^[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning^[2]. 2-Ketoglutaric acid acts as precursor for the synthesis of amino acids and nucleotides^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 2-Ketoglutaric acid-¹³C₂ Related Antibodies
Molecular Weight	148.08
Formula	C₃¹³C₂H₆O₅
CAS No.	123953-28-6
SMILES	OC(CC[13C]([13C](O)=O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief] [2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief] [3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. [Content Brief]

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Keywords:

2-Ketoglutaric acid-¹³C₂123953-28-6Alpha-Ketoglutaric acid-¹³C₂Isotope-Labeled CompoundsTyrosinaseEndogenous MetaboliteInhibitorinhibitorinhibit

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2-Ketoglutaric acid-13C2 (Synonyms: Alpha-Ketoglutaric acid-13C2)

Other Forms of 2-Ketoglutaric acid-13C2:

2-Ketoglutaric acid-13C2 Related Antibodies

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