2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. 2-Ketoglutaric acid potassium

2-Ketoglutaric acid potassium  (Synonyms: Alpha-Ketoglutaric acid potassium)

Cat. No.: HY-W013636C Purity: ≥98.0%
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2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC50 value of 15 mM.

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2-Ketoglutaric acid potassium Chemical Structure

2-Ketoglutaric acid potassium Chemical Structure

CAS No. : 997-43-3

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Based on 3 publication(s) in Google Scholar

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2-Ketoglutaric acid potassium Related Antibodies

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Description

2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium is a reversible inhibitor of tyrosinase with an IC50 value of 15 mM[1][2].

Molecular Weight

185.20

Formula

C5H6KO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(CCC(O)=O)=O)O.[K]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (539.96 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3996 mL 26.9978 mL 53.9957 mL
5 mM 1.0799 mL 5.3996 mL 10.7991 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.3996 mL 26.9978 mL 53.9957 mL 134.9892 mL
5 mM 1.0799 mL 5.3996 mL 10.7991 mL 26.9978 mL
10 mM 0.5400 mL 2.6998 mL 5.3996 mL 13.4989 mL
15 mM 0.3600 mL 1.7999 mL 3.5997 mL 8.9993 mL
20 mM 0.2700 mL 1.3499 mL 2.6998 mL 6.7495 mL
25 mM 0.2160 mL 1.0799 mL 2.1598 mL 5.3996 mL
30 mM 0.1800 mL 0.8999 mL 1.7999 mL 4.4996 mL
40 mM 0.1350 mL 0.6749 mL 1.3499 mL 3.3747 mL
50 mM 0.1080 mL 0.5400 mL 1.0799 mL 2.6998 mL
60 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
80 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.6874 mL
100 mM 0.0540 mL 0.2700 mL 0.5400 mL 1.3499 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2-Ketoglutaric acid potassium Related Classifications

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Keywords:

2-Ketoglutaric acid997-43-3Alpha-Ketoglutaric acidTyrosinaseintermediateprecursorTCAcarbonskeletonInhibitorinhibitorinhibit

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