2-Ketoglutaric acid-¹³C (Synonyms: Alpha-Ketoglutaric acid-¹³C)

Cat. No.: HY-W013636S3: FAQs
Data Sheet SDS COA Handling Instructions

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2-Ketoglutaric acid-¹³C (Alpha-Ketoglutaric acid-¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM).

For research use only. We do not sell to patients.

2-Ketoglutaric acid-<sup>13</sup>C Chemical Structure

2-Ketoglutaric acid-¹³C Chemical Structure

CAS No. : 108395-15-9

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Description

2-Ketoglutaric acid-¹³C (Alpha-Ketoglutaric acid-¹³C) is a ¹³C labeled 2-Ketoglutaric acid (HY-W013636)^[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC₅₀=15 mM)^[2]^[3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

147.09

Formula

C₄¹³CH₆O₅

CAS No.

108395-15-9

Unlabeled CAS

328-50-7

Appearance

Solid

Color

White to light yellow

SMILES

OC(CCC([13C](O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥97.0%

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Data Sheet (267 KB) SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-246. [Content Brief]

[2]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [Content Brief]

[3]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662. [Content Brief]

2-Ketoglutaric acid-¹³C Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Ketoglutaric acid-¹³C108395-15-9Alpha-Ketoglutaric acid-¹³CIsotope-Labeled CompoundsintermediateprecursorTCAcarbonskeletonInhibitorinhibitorinhibit

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2-Ketoglutaric acid-13C (Synonyms: Alpha-Ketoglutaric acid-13C)

Other Forms of 2-Ketoglutaric acid-13C:

2-Ketoglutaric acid-13C Related Antibodies