4-Hydroxydiphenylamine (Synonyms: p-Anilinophenol; 4-Hydroxy-DPA)

Cat. No.: HY-W088320 Purity: 98.02%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

4-Hydroxydiphenylamine (p-Anilinophenol; 4-Hydroxy-DPA) is an aromatic amine organic compound. 4-Hydroxydiphenylamine has antioxidant activity and is also used as a catalyst or intermediate in some chemical reactions to synthesize other compounds. 4-Hydroxydiphenylamine can be used in the research of environmental science and toxicology.

For research use only. We do not sell to patients.

4-Hydroxydiphenylamine Chemical Structure

CAS No. : 122-37-2

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	Get quote	Estimated Time of Arrival: December 31
25 g	Get quote	Estimated Time of Arrival: December 31
50 g	Get quote

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Description

Molecular Weight

185.22

Formula

C₁₂H₁₁NO

CAS No.

122-37-2

Appearance

Solid

Color

Brown to breen

SMILES

OC1=CC=C(C=C1)NC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (539.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3990 mL	26.9949 mL	53.9898 mL
5 mM	1.0798 mL	5.3990 mL	10.7980 mL
10 mM	0.5399 mL	2.6995 mL	5.3990 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (26.99 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (26.99 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.02%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (246 KB) HNMR (112 KB) RP-HPLC (247 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Gardner A M, et al. Microbial degradation of/sup 14/C-diphenylamine in a laboratory model sewage sludge system[J]. Bull. Environ. Contam. Toxicol.;(United States), 1982, 28(1). [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.3990 mL	26.9949 mL	53.9898 mL	134.9746 mL
	5 mM	1.0798 mL	5.3990 mL	10.7980 mL	26.9949 mL
	10 mM	0.5399 mL	2.6995 mL	5.3990 mL	13.4975 mL
	15 mM	0.3599 mL	1.7997 mL	3.5993 mL	8.9983 mL
	20 mM	0.2699 mL	1.3497 mL	2.6995 mL	6.7487 mL
	25 mM	0.2160 mL	1.0798 mL	2.1596 mL	5.3990 mL
	30 mM	0.1800 mL	0.8998 mL	1.7997 mL	4.4992 mL
	40 mM	0.1350 mL	0.6749 mL	1.3497 mL	3.3744 mL
	50 mM	0.1080 mL	0.5399 mL	1.0798 mL	2.6995 mL
	60 mM	0.0900 mL	0.4499 mL	0.8998 mL	2.2496 mL
	80 mM	0.0675 mL	0.3374 mL	0.6749 mL	1.6872 mL
	100 mM	0.0540 mL	0.2699 mL	0.5399 mL	1.3497 mL

4-Hydroxydiphenylamine Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxydiphenylamine122-37-2p-Anilinophenol 4-Hydroxy-DPADrug IntermediateDrug IintermediateAromatic aminesantioxidant activityintermediatestoxicologyInhibitorinhibitorinhibit

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4-Hydroxydiphenylamine (Synonyms: p-Anilinophenol; 4-Hydroxy-DPA)

4-Hydroxydiphenylamine Related Antibodies

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