2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Ethylvanillin

Ethylvanillin is an orally active antioxidant that can affect cytochrome P450 activity in rats. It can also be used as a food flavoring agent in the field of food processing.

For research use only. We do not sell to patients.

Ethylvanillin Chemical Structure

Ethylvanillin Chemical Structure

CAS No. : 121-32-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Ethylvanillin:

Ethylvanillin Related Antibodies

Top Publications Citing Use of Products

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ethylvanillin is an orally active antioxidant that can affect cytochrome P450 activity in rats. It can also be used as a food flavoring agent in the field of food processing[1][2].

In Vitro

Ethylvanillin (25 mM, 180 min) inhibits AAPH-induced hemolysis in the erythrocyte suspension in erythrocyte oxidative assay[1].
Ethylvanillin (20 mM, 2 hours) shows antioxidant activity in the erythrocyte suspension in ABTS radical assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ethylvanillin Related Antibodies
In Vivo

Ethylvanillin (32.7 mg/kg, p.o., single dose) increases plasma ethyl vanillic acid levels and antioxidant activity in ICR mice[2].
Ethylvanillin (3, 15, and 75 mg/kg, p.o., once daily for 7 days) induces CYP2E1 activity and inhibits CYP1A2 activity in Wistar rats [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (6 weeks)[1]
Dosage: 32.7 mg/kg
Administration: Oral gavage (p.o.), single dose
Result: Increased ethyl vanillic acid metabolite concentration in plasma;
Raised antioxidant activity in plasma.
Animal Model: Wistar rats (6 weeks, 180-200 g)[1]
Dosage: 3, 15, 75 mg/kg
Administration: Oral gavage (p.o.), once daily for 7 days
Result: Increased CYP2E1 activity, decreased CYP1A2 activity.
Molecular Weight

166.18

Formula

C9H10O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=CC1=CC=C(O)C(OCC)=C1
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

Ethanol : ≥ 100 mg/mL (601.77 mM)

DMSO : ≥ 100 mg/mL (601.77 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 5 mg/mL (30.09 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0177 mL 30.0886 mL 60.1772 mL
5 mM 1.2035 mL 6.0177 mL 12.0354 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (246 KB) LCMS (111 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / Ethanol / DMSO 1 mM 6.0177 mL 30.0886 mL 60.1772 mL 150.4429 mL
5 mM 1.2035 mL 6.0177 mL 12.0354 mL 30.0886 mL
10 mM 0.6018 mL 3.0089 mL 6.0177 mL 15.0443 mL
15 mM 0.4012 mL 2.0059 mL 4.0118 mL 10.0295 mL
20 mM 0.3009 mL 1.5044 mL 3.0089 mL 7.5221 mL
25 mM 0.2407 mL 1.2035 mL 2.4071 mL 6.0177 mL
30 mM 0.2006 mL 1.0030 mL 2.0059 mL 5.0148 mL
Ethanol / DMSO 40 mM 0.1504 mL 0.7522 mL 1.5044 mL 3.7611 mL
50 mM 0.1204 mL 0.6018 mL 1.2035 mL 3.0089 mL
60 mM 0.1003 mL 0.5015 mL 1.0030 mL 2.5074 mL
80 mM 0.0752 mL 0.3761 mL 0.7522 mL 1.8805 mL
100 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.5044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ethylvanillin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ethylvanillin121-32-4Cytochrome P450CYPsAntioxidant activityErythrocyte suspensionFood additiveInhibitorinhibitorinhibit

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