2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. K-Ras G12C-IN-3

K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.

For research use only. We do not sell to patients.

K-Ras G12C-IN-3 Chemical Structure

K-Ras G12C-IN-3 Chemical Structure

CAS No. : 1629268-19-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 419 In-stock
Solution
10 mM * 1 mL in DMSO USD 419 In-stock
Solid
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

K-Ras G12C-IN-3 Related Antibodies

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. IC50 value: Target: K-ras G12C inhibitor For more information, please see the following patent. Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereof By Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.

Molecular Weight

453.75

Formula

C21H19Cl3N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (66.12 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2039 mL 11.0193 mL 22.0386 mL
5 mM 0.4408 mL 2.2039 mL 4.4077 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

SDS (394 KB)

COA (247 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2039 mL 11.0193 mL 22.0386 mL 55.0964 mL
5 mM 0.4408 mL 2.2039 mL 4.4077 mL 11.0193 mL
10 mM 0.2204 mL 1.1019 mL 2.2039 mL 5.5096 mL
15 mM 0.1469 mL 0.7346 mL 1.4692 mL 3.6731 mL
20 mM 0.1102 mL 0.5510 mL 1.1019 mL 2.7548 mL
25 mM 0.0882 mL 0.4408 mL 0.8815 mL 2.2039 mL
30 mM 0.0735 mL 0.3673 mL 0.7346 mL 1.8365 mL
40 mM 0.0551 mL 0.2755 mL 0.5510 mL 1.3774 mL
50 mM 0.0441 mL 0.2204 mL 0.4408 mL 1.1019 mL
60 mM 0.0367 mL 0.1837 mL 0.3673 mL 0.9183 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

K-Ras G12C-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

K-Ras G12C-IN-31629268-19-4RasInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
K-Ras G12C-IN-3
Cat. No.:
HY-18606
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (394 KB) Français - FR (394 KB) Deutsch - DE (394 KB) Norwegian - NO (394 KB) Español - ES (394 KB) Swedish - SV (394 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.