2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Prazosin

Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease.

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Prazosin Chemical Structure

Prazosin Chemical Structure

CAS No. : 19216-56-9

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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Prazosin:

Prazosin Related Antibodies

Top Publications Citing Use of Products

    Prazosin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Apr;124:109731.  [Abstract]

    The expression of TNS1 in U937 and HL60 cells treated with different concentration of Prazosin is detected by Western blot analysis

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease[1][2][3][4].

    In Vitro

    Prazosin (50 μM, 18 h) can reduce the production of amyloid beta in N2a cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Prazosin Related Antibodies

    Western Blot Analysis[2]

    Cell Line: N2asw
    Concentration: 50 μM
    Incubation Time: 18 h
    Result: Reduced Aβ levels, induced a significant increase in APP-CTFs, and significantly reduced the production of CTFγ.
    In Vivo

    Prazosin (1 mg/kg, injected into the abdomen once daily, two weeks) can prevent memory deficits in mice by altering the release of inflammatory mediators and astrocytes, alleviating symptoms of Alzheimer's disease[2].
    Prazosin (0.1-2 mg/kg, 3-6 mM, administered systemically or locally, in a single dose) can promote fear extinction in mice[3].
    Prazosin (0.01-1 mg/kg, subcutaneously, in a single dose) can enhance the analgesic effects of morphine in mice[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: APP23 mice[2]
    Dosage: 1 mg/kg; daily; 2 weeks
    Administration: Intraperitoneal injection (i.p.)
    Result: Increased mean freezing time during acclimation, attenuated hippocampal-dependent memory decline, did not affect APP processing or Aβ aggregation in vivo, and increased the number of astrocytes and secretion of anti-inflammatory mediators in APP23 mice.
    Animal Model: C57B1/6N mouse[3]
    Dosage: 0.1-2 mg/kg; 3 and 6 mM; single dose
    Administration: systemic (0.1-2 mg/kg) or local microinjections (3 or 6 mM) into the prelimbic division of medial prefrontal cortex or basolateral amygdala
    Result: Had no effect on fear memory, but indirectly promoted fear extinction by interfering with the initial fear acquisition process.
    Animal Model: C57BL/6J mice[4]
    Dosage: 0.01, 0.1, 0.25, 0.5, 1 mg/kg; single dose
    Administration: Subcutaneous injection (s.c.)
    Result: Had no analgesic effect when used alone, but it enhanced the analgesic effect of morphine and reduced weight loss after morphine withdrawal.
    Clinical Trial
    Molecular Weight

    383.40

    Formula

    C19H21N5O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=CC=CO4
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 41.67 mg/mL (108.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6082 mL 13.0412 mL 26.0824 mL
    5 mM 0.5216 mL 2.6082 mL 5.2165 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 5 mg/mL (13.04 mM); Clear solution

      This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.28%

    COA (249 KB) HNMR (259 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.6082 mL 13.0412 mL 26.0824 mL 65.2061 mL
    5 mM 0.5216 mL 2.6082 mL 5.2165 mL 13.0412 mL
    10 mM 0.2608 mL 1.3041 mL 2.6082 mL 6.5206 mL
    15 mM 0.1739 mL 0.8694 mL 1.7388 mL 4.3471 mL
    20 mM 0.1304 mL 0.6521 mL 1.3041 mL 3.2603 mL
    25 mM 0.1043 mL 0.5216 mL 1.0433 mL 2.6082 mL
    30 mM 0.0869 mL 0.4347 mL 0.8694 mL 2.1735 mL
    40 mM 0.0652 mL 0.3260 mL 0.6521 mL 1.6302 mL
    50 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.3041 mL
    60 mM 0.0435 mL 0.2174 mL 0.4347 mL 1.0868 mL
    80 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8151 mL
    100 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6521 mL
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    Prazosin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Prazosin19216-56-9Adrenergic ReceptorBeta ReceptorMemory losshypertensionanti-inflammatoryanti-anxietyInhibitorinhibitorinhibit

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