2. Infection

Infection

Infection

Infection

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Infection is a pathophysiological process that involves the invasion and colonization of a living organism (host) by disease-causing infectious agents, the reaction of host tissues to these agents and the toxins they produce, and the transmission of infectious agents to other hosts. Common infectious agents include viruses, viroids, prions, bacteria, nematodes, arthropods, and other macroparasites such as tapeworms. Hosts can fight infections using their immune system. Mammals often engage both innate and adaptive immune systems to eliminate infectious agents or inhibit their growth and transmission. When infection occurs, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs exist, depending on the type of organism targeted; they include antibacterial (antibiotic), antiviral, antifungal and antiparasitic agents.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-139628
    JPD447 2883235-86-5 99.80%
    JPD447, a MAC-0547630 derivative, is a novel class of UppS inhibitor to potentiate β-lactam antibiotics.
    JPD447
  • HY-141622
    SDZ 224-015 161511-45-1
    SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM).
    SDZ 224-015
  • HY-141715
    BRD-8000.3 2365504-95-4 ≥98.0%
    BRD-8000.3, as a specific EfpA inhibitor, is a narrow-spectrum, bactericidal antimycobacterial agent with good wild-type activity. BRD-8000.3 can be used for the research of tuberculosis.
    BRD-8000.3
  • HY-148706
    STAT3-IN-17 1245814-52-1 ≥98.0%
    STAT3-IN-17 is a moderate STAT3 inhibitor (IC50=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori.
    STAT3-IN-17
  • HY-149606
    TKB245 2892688-16-1 98.98%
    TKB245 is a highly potent SARS-CoV-2 Mpro inhibitor that effectively blocks SARS-CoV-2 replication in VeroE6 cells.
    TKB245
  • HY-151167
    LasR-IN-4 183488-96-2 99.52%
    LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production.
    LasR-IN-4
  • HY-155635
    Nav1.8-IN-4 1620846-16-3 99.78%
    Nav1.8-IN-4 (compound 9a) is a Nav1.8 channel inhibitor (IC50=0.014 μM). Nav1.8-IN-4 can be used for research on pain-related diseases.
    Nav1.8-IN-4
  • HY-163901
    E6-272 945142-65-4 99.93%
    E6-272 is an inhibitor for human papillomavirus 16 (HPV 16). E6-272 inhibits the proliferation of HPV-positive cells SiHa and CaSki with GI50 of 32 nM and 62 nM. E6-272 induces apoptosis in cell SiHa and CaSki.
    E6-272
  • HY-17503R
    Metoprolol (Standard) 51384-51-1
    Metoprolol (Standard) is the analytical standard of Metoprolol. This product is intended for research and analytical applications. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties.
    Metoprolol (Standard)
  • HY-A0147A
    Grepafloxacin hydrochloride 161967-81-3 99.23%
    Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinolone antibiotic with potent activity against community-acquired respiratory pathogens including Streptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile.
    Grepafloxacin hydrochloride
  • HY-B0035S
    Sulfamethazine-d4 1020719-82-7 99.91%
    Sulfamethazine-d4 is a deuterium labeled Sulfamethazine (Sulfadimidine). Sulfamethazine is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections)[1][2].
    Sulfamethazine-d4
  • HY-B0101S
    Fluconazole-d4 1124197-58-5 99.66%
    Fluconazole-d4 is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].
    Fluconazole-d4
  • HY-B1128A
    Cefamandole sodium 30034-03-8
    Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.
    Cefamandole sodium
  • HY-B1144A
    Chlormidazole hydrochloride 74298-63-8 98.98%
    Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses.
    Chlormidazole hydrochloride
  • HY-B1190A
    Cefadroxil hydrate 66592-87-8 ≥99.0%
    Cefadroxil hydrate (BL-S 578 hydrate) is an orally active and first-generation cephalosporin with a broad spectrum antibacterial activity. Cefadroxil hydrate (BL-S 578 hydrate) also acts as a substrate of the peptide transporter PEPT1 and PEPT2.
    Cefadroxil hydrate
  • HY-B2144I
    Chitosan (≥90% deacetylated,viscosity 10 mPa.s) 9012-76-4
    Chitosan (Deacetylated chitin) (≥90% deacetylated,viscosity 10 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan (≥90% deacetylated,viscosity 10 mPa.s) can be used as a versatile biomaterial in drug delivery, tissue engineering, and wound healing.
    Chitosan (≥90% deacetylated,viscosity 10 mPa.s)
  • HY-E70079
    Cystathionine β-lyase, Recombinant Microorganisms 9055-05-4
    Cystathionine β-lyase, Recombinant Microorganisms (CBL) is an enzyme that catalyzes the breakdown of cystathionine to homocysteine, the penultimate step in methionine biosynthesis. Cystathionine β-lyase is important for bacterial virulence.
    Cystathionine β-lyase, Recombinant Microorganisms
  • HY-N0492A
    α-Lipoic Acid sodium 2319-84-8 99.92%
    α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.
    α-Lipoic Acid sodium
  • HY-N0717A
    D-Valine 640-68-6 ≥98.0%
    D-Valine is the enantiomer of L-Valine (HY-N0717). L-Valine is one of 20 proteinogenic amino acids. L-Valine is an essential amino acid.
    D-Valine
  • HY-N10420
    Hinokinin 26543-89-5 99.38%
    Hinokinin (Compound 1) is a compound isolated from the stems of Hypoestes aristate. Hinokinin exhibits moderate activity of HIV-1 protease enzyme.
    Hinokinin
Cat. No. Product Name / Synonyms Application Reactivity