2. Signaling Pathways
  3. Stem Cell/Wnt
    TGF-beta/Smad
  4. PKA

PKA

PKA

Protein kinase A

PKA

Related Products

PDF 0.04 MB

PKA (Protein kinase A) is a Ser/Thr phosphoryl transferase that transfers the γ-phosphate group of ATP to protein substrates. PKA phosphorylates more than 100 cytoplasmic and membrane associated targets. PKA mediates a myriad of cellular signaling events and its activity is tightly regulated both in space and time.

PKA is an evolutionarily conserved negative regulator of the hedgehog (Hh) signal transduction pathway. PKA is known to be required for the proteolytic processing event that generates the repressor forms of the Ci and Gli transcription factors that keep target genes off in the absence of Hh.

PKA Isoform Specific Products:

PKA Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W015782
    4-Ethylresorcinol
    		Inhibitor 99.71%
    4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value.
    4-Ethylresorcinol
  • HY-132302A
    Hu7691 free base
    		Inhibitor
    Hu7691 free base is an orally active, selective Akt inhibitor with IC50s of 4.0 nM, 97.5 nM, 28 nM for Akt1, Akt2 and Akt3, respectively. Hu7691 free base inhibits tumor growth and enables decrease of cutaneous toxicity in mice.
    Hu7691 free base
  • HY-10341C
    Fasudil dihydrochloride
    		Inhibitor
    Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil dihydrochloride
  • HY-10341B
    Fasudil hydrochloride semihydrate
    		Inhibitor
    Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil hydrochloride semihydrate
  • HY-P2473
    Neurogranin (48-76), human
    		Activator
    Neurogranin (48-76), human is a dominant endogenous peptide in Alzheimer's disease (AD) brain tissue. Neurogranin (48-76) is a potential biomarker for synaptic function in AD.
    Neurogranin (48-76), human
  • HY-110005
    Sp-cAMPS triethylamine
    		Activator
    Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC50 of 40 μM.
    Sp-cAMPS triethylamine
  • HY-120994B
    Sp-8-CPT-cAMPS
    		Activator
    Sp-8-CPT-cAMPS, a cAMP analog, is a potent and selective activator of the cAMP-dependent protein kinas A (PKA I and PKA II). Sp-8-CPT-cAMPS selects site A of RI compares to site A of RII by 153-fold and site B of RII compares to site B of RI by 59-fold.
    Sp-8-CPT-cAMPS
  • HY-130060
    12(S)-HETrE
    		Agonist
    12(S)-HETrE is a fatty acid metabolite that inhibits platelet aggregation. 12(S)-HETrE can be used in thrombosis-related research.
    12(S)-HETrE
  • HY-126376
    Iso-​H7 dihydrochloride
    		Inhibitor
    Iso-​H7 dihydrochloride is an inhibitor of protein kinase with IC50 values of 22 and 34 μM to PKC and PKA respectively. Iso-H7 dihydrochloride has negative control of PKA on satellite cell myogenesis.
    Iso-​H7 dihydrochloride
  • HY-150073
    DS01080522
    		Inhibitor
    DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.
    DS01080522
  • HY-137640A
    Sp-8-Br-cAMPS sodium
    		Agonist
    Sp-8-Br-cAMPS sodium is a cAMP analog, which performs a protein kinase A (PKA) activating activity with EC50 of 360 nM. Sp-8-Br-cAMPS sodium inhibits proliferation of T cells and the haemocyte non-self response in Lepidoptera larve.
    Sp-8-Br-cAMPS sodium
  • HY-121828
    TX-1123
    		Inhibitor
    TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src, eEF2-K, and PKA, and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer.
    TX-1123
  • HY-B1899R
    Taurodeoxycholic acid (Standard)
    		Activator
    Taurodeoxycholic acid (Standard) is the analytical standard of Taurodeoxycholic acid. This product is intended for research and analytical applications. Taurodeoxycholate sodium salt is a bile salt-related anionic detergent. Taurodeoxycholic acid is formed in the liver by conjugation of deoxycholate with Taurine (HY-B0351). Taurodeoxycholic acid is used for isolation of membrane proteins including inner mitochondrial membrane proteins. Taurodeoxycholic acid (TDCA) exhibits anti-inflammatory and neuroprotective effects[1][2][3][9][10].
    Taurodeoxycholic acid (Standard)
  • HY-P0228
    PKA RII peptide
    PKA RII peptide is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity.
    PKA RII peptide
  • HY-15141R
    Staurosporine (Standard)
    		Inhibitor
    Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].
    Staurosporine (Standard)
  • HY-150072A
    (2S,4R)-DS89002333
    		Control
    (2S,4R)-DS89002333 is the enantiomer of DS89002333 (HY-150072). DS89002333 is an orally active and potent PRKACA inhibitor, with an IC50 of 0.3 nM.
    (2S,4R)-DS89002333
  • HY-P3745
    H1-7 (histone H1 phosphorylation site), PKA Substrate
    H1-7 (histone H1 phosphorylation site), PKA Substrate, a synthetic polypeptide, can be used as PKA substrate.
    H1-7 (histone H1 phosphorylation site), PKA Substrate
  • HY-148827A
    GEM-231 sodium
    		Inhibitor
    GEM231 sodium is an 18mer antisense oligonucleotide targeting the mRNA of the PKA-I (RIα regulatory subunit of cAMP dependent protein kinase type I ). GEM231 sodium induces cell growth arrest, apoptosis, and differentiation in a variety of cancer cell lines in vitro and in tumors in vivo.
    GEM-231 sodium
  • HY-120994A
    Rp-8-CPT-cAMPS
    		Antagonist
    Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.
    Rp-8-CPT-cAMPS
  • HY-112348
    HA-1004 hydrochloride
    		Inhibitor
    HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.
    HA-1004 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
PKA Isoform Comparison

PKA

PKAR

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

PKA Inhibitors, Agonists & Activators
Product NamePKAPKARPurity    
Bucladesine sodium
PKA
 99.48%
PKC-IN-6
PKA, IC50: >500 μM
 99.63%
Fasudil Hydrochloride
PKA, IC50: 4.58 μM
 99.97%
Bucladesine calcium
PKA
 99.52%
Daphnetin
PKA, IC50: 9.33 μM
 99.77%
KT5823
PKA, Ki: 10 μM
 99.90%
PKA Inhibitor Fragment (6-22) amide TFA
PKA, Ki: 2.8 nM
 99.87%
AT13148
PKA, IC50: 3 nM
 99.21%
AT7867
PKA, IC50: 20 nM
 99.88%
Bilobetin
PKA
 99.39%
Sp-cAMPS sodium salt
PKA I
PKA II
 99.45%
CW 008
PKA
 98.15%
AT7867 dihydrochloride
PKA, IC50: 20 nM
 99.75%
Hu7691
PKA, IC50: 11 nM
 99.91%
Jaspamycin
Trypanosoma brucei PKA holoenzyme, Kd: 8 nM
Trypanosoma brucei PKAR(199-499), EC50: 6.5 nM
98.60%
Sp-cAMPS
PKA I
PKA II
 
A-3 hydrochloride
PKA, Ki: 4.3 μM
 99.75%
PF-4950834
PKA, IC50: 424 nM
 99.60%
Akt1&PKA-IN-1
PKAa, IC50: 0.03 μM
 
Fasudil
PKA, IC50: 4.58 μM
 
Hu7691 free base
PKA, IC50: 11 nM
 
Fasudil dihydrochloride
PKA, IC50: 4.58 μM
 
Fasudil hydrochloride semihydrate
PKA, IC50: 4.58 μM
 
Sp-cAMPS triethylamine
PKA I
PKA II
 
Sp-8-Br-cAMPS sodium
PKA, EC50: 360 nM
 
PKA Inhibitor Fragment (6-22) amide
PKA, Ki: 2.8 nM
 
HA-100 hydrochloride
PKA, IC50: 8 μM
 
HA-100 dihydrochloride
PKA, IC50: 8 μM
 
GSK466317A
PKA, IC50: 12.59 μM
 
Balanol
PKA
 
LX7101 monohydrochloride
PKA, IC50: <1 nM