2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Na+/H+ Exchanger (NHE)

Na+/H+ Exchanger (NHE)

Sodium/hydrogen Exchanger; Sodium-hydrogen Exchanger

Na+/H+ exchanger (sodium/hydrogen exchanger, NHE) family exchanges Na+ for H+ according to their concentration gradients, thus promotes the regulation of the stability of cytoplasmic pH and cell volume.

There are nine isoforms of NHE in humans, some NHEs function primarily on the plasma membrane, and others are present on intracellular organelles. NHE1 is expressed in the plasma membrane of virtually all tissues and plays an important role in cardiac health. NHE2 is expressed in the gastrointestinal (GI) tract and contributes to the maintenance of stomach pH and homeostasis, whereas NHE3 predominates in the GI tract and kidneys. NHE4 and NHE5 are abundant in the stomach and brain, respectively. NHE6-9 are expressed in the intracellular compartments of many organ system membranes, but of these NHE8 is the exception and expressed apically.

Na+/H+ Exchanger (NHE) Related Products (32):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100325
    NHE3-IN-1
    		Inhibitor 98.05%
    NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.
    NHE3-IN-1
  • HY-N10156
    1,3,5-Trihydroxy-4-prenylxanthone
    		Inhibitor
    1,3,5-Trihydroxy-4-prenylxanthone is a Na+/H+ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL. 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC50 value of 3.0 μM. 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities.
    1,3,5-Trihydroxy-4-prenylxanthone
  • HY-120623
    BMS-284640
    		Inhibitor
    BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 μM) and NHE-5 (IC50: 3.36 μM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats..
    BMS-284640
  • HY-150269
    RS5517
    		Inhibitor
    RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer.
    RS5517
  • HY-106150
    Eniporide
    		Inhibitor
    Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor. Eniporide specifically inhibits the NHE-1 isoform. Eniporide improves cardiac performance inhibition associated with myocardial ischemia/reperfusion in animals, and limits infarct size in experimental models. Eniporide regulates cardiac performance and high-energy phosphate content in clinically relevant pig models of CPB and cardiac arrest.
    Eniporide
  • HY-163365
    UTX-143
    		Inhibitor
    UTX-143 is an inhibitor of Na+/H+ exchange protein (NHE5). UTX-143 has antitumor activity.
    UTX-143
  • HY-100302
    FR183998 free base
    		Inhibitor 98.00%
    FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
    FR183998 free base
  • HY-132181
    Dimethylamiloride hydrochloride
    		Inhibitor
    Dimethylamiloride hydrochloride is a Na+/H+ exchanger NHE inhibitor with Ki values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research.
    Dimethylamiloride hydrochloride
  • HY-118778
    KR-32568
    		Inhibitor 99.80%
    KR-32568 is a sodium/hydrogen exchanger-1 (NHE-1) inhibitor with an IC50 of 230 nM. KR-32568 has cardioprotective effects.
    KR-32568
  • HY-125144
    BIIB 513
    		Inhibitor
    BIIB 513 is an inhibitor of NHE 1 that protects against myocardial ischemia. BIIB 513 inhibits acid load recovery with an IC50 of 27 nmol/L in cells expressing wild-type NHE 1 under acute acid load.
    BIIB 513
  • HY-W704968
    2-Oxo-zoniporide hydrochloride
    		Inhibitor
    2-Oxo-zoniporide hydrochloride is an oral active sodium-hydrogen exchanger type 1 (NHE-1) inhibitor and can be used for study of myocardial ischemic injury.
    2-Oxo-zoniporide hydrochloride
  • HY-19273A
    Rimeporide hydrochloride
    		Inhibitor
    Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1).
    Rimeporide hydrochloride