Alizapride hydrochloride

Name: Alizapride hydrochloride
Brand: MedChemExpress
SKU: HY-A0125A
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0125A Purity: 99.28%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders.

For research use only. We do not sell to patients.

Alizapride hydrochloride Chemical Structure

CAS No. : 59338-87-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 99	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 99	In-stock	Estimated Time of Arrival: December 31
Solid
50 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Alizapride hydrochloride:

Alizapride Get quote
Alizapride-¹³C,d₃ hydrochloride Get quote

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View All Dopamine Receptor Isoform Specific Products:

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders^[1]^[3].

IC₅₀ & Target

Dopamine receptor^[1]

In Vivo

Alizapride (2.5, 5, 10, 25 μg/kg; SC; 7 consecutive days) significantly reduces the bound IgG-sensitized erythrocytes with Splenic macrophages isolated from animals^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Duncan–Hartley guinea pigs^[2]
Dosage:	2.5, 5, 10, 25 μg/kg
Administration:	Alizapride (2.5, 5, 10, 25 μg/kg; SC; 7 consecutive days)
Result:	Reduced the clearance of IgG-sensitized RBCs.

Molecular Weight

351.83

Formula

C₁₆H₂₂ClN₅O₂

CAS No.

59338-87-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(OC)C=C(NN=N2)C2=C1)NCC3N(CC=C)CCC3.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (284.23 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (94.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8423 mL	14.2114 mL	28.4228 mL
5 mM	0.5685 mL	2.8423 mL	5.6846 mL
10 mM	0.2842 mL	1.4211 mL	2.8423 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (142.11 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Bleiberg H, et al. Activity of a new antiemetic agent: alizapride. A randomized double-blind crossover controlled trial. Cancer Chemother Pharmacol. 1988;22(4):316-20. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.8423 mL	14.2114 mL	28.4228 mL	71.0570 mL
	5 mM	0.5685 mL	2.8423 mL	5.6846 mL	14.2114 mL
	10 mM	0.2842 mL	1.4211 mL	2.8423 mL	7.1057 mL
	15 mM	0.1895 mL	0.9474 mL	1.8949 mL	4.7371 mL
	20 mM	0.1421 mL	0.7106 mL	1.4211 mL	3.5529 mL
	25 mM	0.1137 mL	0.5685 mL	1.1369 mL	2.8423 mL
	30 mM	0.0947 mL	0.4737 mL	0.9474 mL	2.3686 mL
	40 mM	0.0711 mL	0.3553 mL	0.7106 mL	1.7764 mL
	50 mM	0.0568 mL	0.2842 mL	0.5685 mL	1.4211 mL
	60 mM	0.0474 mL	0.2369 mL	0.4737 mL	1.1843 mL
	80 mM	0.0355 mL	0.1776 mL	0.3553 mL	0.8882 mL
H₂O	100 mM	0.0284 mL	0.1421 mL	0.2842 mL	0.7106 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.