2. Metabolic Enzyme/Protease Anti-infection
  3. Cytochrome P450 Fungal
  4. Antifungal agent 114

Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes.

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Antifungal agent 114

Antifungal agent 114 Chemical Structure

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes[1].

Molecular Weight

506.93

Formula

C23H18ClF3N4O2S
SMILES

O=C(C1=CC=C(C2=CC=C(Cl)C=C2F)S1)N(CC(O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antifungal agent 114 Related Classifications

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Keywords:

Antifungal agent 114Antifungal agent114Antifungal agent-114Cytochrome P450FungalCYPsantifungalCryptococcus neoformansCandidaAspergillusInhibitorinhibitorinhibit

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