2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Cirtociclib

Cirtociclib (BLU-222) is an orally active and highly selective CDK2 inhibitor. Cirtociclib disrupts Rb signaling and causes G1 arrest and apoptosis in CCNE1-amplified endometrial cancer cells.

For research use only. We do not sell to patients.

Cirtociclib Chemical Structure

Cirtociclib Chemical Structure

CAS No. : 2888704-84-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 387 In-stock
Solution
10 mM * 1 mL in DMSO USD 407 In-stock
Solid
5 mg USD 370 In-stock
10 mg USD 640 In-stock
25 mg USD 1280 In-stock
50 mg USD 2250 In-stock
100 mg USD 3950 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cirtociclib (BLU-222) is an orally active and highly selective CDK2 inhibitor. Cirtociclib disrupts Rb signaling and causes G1 arrest and apoptosis in CCNE1-amplified endometrial cancer cells[1][2][3].

In Vitro

Cirtociclib (BLU-222) (25-250 nM; 0-288 h) exhibits antiproliferative activity against KLE and HEC-1-B cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Cirtociclib (BLU-222) (60 mg/kg; twice daily) shows significant anti-tumor activity in both endometrial cancer PDX models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

365.34

Formula

C15H17F2N7O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

FC(OC1=CC(NC2=NC3=C(C=NN3CC4CCOCC4)N=C2)=NN1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (273.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7372 mL 13.6859 mL 27.3718 mL
5 mM 0.5474 mL 2.7372 mL 5.4744 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.02%

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (136 KB) RP-HPLC (231 KB) LCMS (203 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7372 mL 13.6859 mL 27.3718 mL 68.4294 mL
5 mM 0.5474 mL 2.7372 mL 5.4744 mL 13.6859 mL
10 mM 0.2737 mL 1.3686 mL 2.7372 mL 6.8429 mL
15 mM 0.1825 mL 0.9124 mL 1.8248 mL 4.5620 mL
20 mM 0.1369 mL 0.6843 mL 1.3686 mL 3.4215 mL
25 mM 0.1095 mL 0.5474 mL 1.0949 mL 2.7372 mL
30 mM 0.0912 mL 0.4562 mL 0.9124 mL 2.2810 mL
40 mM 0.0684 mL 0.3421 mL 0.6843 mL 1.7107 mL
50 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3686 mL
60 mM 0.0456 mL 0.2281 mL 0.4562 mL 1.1405 mL
80 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.8554 mL
100 mM 0.0274 mL 0.1369 mL 0.2737 mL 0.6843 mL
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Cirtociclib Related Classifications

Keywords:

Cirtociclib2888704-84-3BLU-222BLU222BLU 222CDKApoptosisCyclin dependent kinaseCDK2AntitumorInhibitorinhibitorinhibit

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