Casimersen sodium  (Synonyms: SRP-4045 sodium)

Casimersen sodium is an antisense oligonucleotide of the phosphorodiamidate morpholino oligomer subclass. Casimersen sodium binds to exon 45 of dystrophin pre-mRNA, restores the open-reading frame (by skipping exon 45) resulting in the production of an internally truncated but functional dystrophin protein. Casimersen sodium can be used for the research of Duchenne muscular dystrophy (DMD)^[1].

8068.01

C₂₆₈H₄₀₂N₁₂₄Na₂₂O₉₅P₂₂

Solid

White to off-white

[Casimersen (sodium)]

Room temperature in continental US; may vary elsewhere.

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Shirley M. Casimersen: First Approval. Drugs. 2021;81(7):875-879.  [Content Brief]

  [2]. Casimersen. Am J Health Syst Pharm. 2021;78(13):1149-1150.  [Content Brief]

  [3]. Carver MP, Charleston JS, Shanks C, et al. Toxicological Characterization of Exon Skipping Phosphorodiamidate Morpholino Oligomers (PMOs) in Non-human Primates. J Neuromuscul Dis. 2016;3(3):381-393. doi:10.3233/JND-160157  [Content Brief]