2. PROTAC Apoptosis Autophagy
  3. Ligands for E3 Ligase Autophagy Apoptosis
  4. Cereblon inhibitor 2

Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer.

For research use only. We do not sell to patients.

Cereblon inhibitor 2 Chemical Structure

Cereblon inhibitor 2 Chemical Structure

CAS No. : 2639380-62-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 220 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 330 In-stock
25 mg USD 660 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Cereblon inhibitor 2 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cereblon inhibitor 2 (compound 8) is a Cereblon inhibitor useful in solid tumor research, especially breast cancer[1].

Molecular Weight

440.88

Formula

C22H21ClN4O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C2C(C(N(C3C(NC(CC3)=O)=O)C2)=O)=C1)NC4=CC=C(C)C(Cl)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (453.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2682 mL 11.3410 mL 22.6819 mL
5 mM 0.4536 mL 2.2682 mL 4.5364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (11.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2682 mL 11.3410 mL 22.6819 mL 56.7048 mL
5 mM 0.4536 mL 2.2682 mL 4.5364 mL 11.3410 mL
10 mM 0.2268 mL 1.1341 mL 2.2682 mL 5.6705 mL
15 mM 0.1512 mL 0.7561 mL 1.5121 mL 3.7803 mL
20 mM 0.1134 mL 0.5670 mL 1.1341 mL 2.8352 mL
25 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2682 mL
30 mM 0.0756 mL 0.3780 mL 0.7561 mL 1.8902 mL
40 mM 0.0567 mL 0.2835 mL 0.5670 mL 1.4176 mL
50 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
60 mM 0.0378 mL 0.1890 mL 0.3780 mL 0.9451 mL
80 mM 0.0284 mL 0.1418 mL 0.2835 mL 0.7088 mL
100 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
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Cereblon inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cereblon inhibitor 22639380-62-2Cereblon inhibitor2Cereblon inhibitor-2Ligands for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyCereblonInhibitorinhibitorinhibit

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