COQ7-IN-1

Name: COQ7-IN-1
Brand: MedChemExpress
SKU: HY-133033
Rating: 4.5 (1 reviews)

Cat. No.: HY-133033 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

COQ7-IN-1, a highly potent inhibitor of human coenzyme Q (COQ7), interferes with ubiquinone (UQ) synthesis. COQ7-IN-1 does not disturb physiological cell growth of human normal culture cells. COQ7-IN-1 can be used for the research of the balance between UQ supplementation pathways: de novo UQ synthesis and extracellular UQ uptake.

For research use only. We do not sell to patients.

COQ7-IN-1 Chemical Structure

CAS No. : 2579696-72-1

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 110	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 110	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
C3A	GI₅₀	6.1 μM Compound: 8	Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay	[PMID: 31753803]
C3A	GI₅₀	9 μM Compound: 8	Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay	[PMID: 31753803]
HeLa	GI₅₀	> 12 μM Compound: 8	Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay	[PMID: 31753803]
PANC-1	GI₅₀	> 12 μM Compound: 8	Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay	[PMID: 31753803]
PC-3	GI₅₀	> 12 μM Compound: 8	Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay	[PMID: 31753803]
WI-38	GI₅₀	> 12 μM Compound: 8	Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay	[PMID: 31753803]
WI-38	GI₅₀	19 μM Compound: 8	Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 4 days by cell-titer-Glo assay	[PMID: 31753803]

In Vitro

COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cells growth with a GI₅₀ of 19.0 μM. COQ7-IN-1 weakly inhibits C3A cells growth with GI₅₀ of 9.0±1.1 μM. COQ7-IN-1 does not limit C3A cell survival through inhibiting aerobic respiration or increasing oxidative stress^[1].
COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), and then converted to UQ by COQ3. Cells under COQ7 deficiency are unable to produce UQ, and consequently accumulate DMQ. DMQ10 and UQ10 contents in each culture well are 13.2 and 12.2 ng/well for COQ7-IN-1 (10 μM; for 2 days) cultured with HeLa cells. DMQ10 content of COQ7-IN-1 in HeLa cells is 52.0%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	WI-38 cells
Concentration:	0-30 μM
Incubation Time:	4 days
Result:	The concentration that caused 50% cell growth inhibition (GI₅₀) was 19.0 μM.

Molecular Weight

271.70

Formula

C₁₄H₁₀ClN₃O

CAS No.

2579696-72-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC(C2=CC=CC=C2)=NN1C3=CC=C(Cl)C=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (368.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6805 mL	18.4026 mL	36.8053 mL
5 mM	0.7361 mL	3.6805 mL	7.3611 mL
10 mM	0.3681 mL	1.8403 mL	3.6805 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (7.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (250 KB) RP-HPLC (206 KB)

Handling Instructions (2659 KB)

References

[1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6805 mL	18.4026 mL	36.8053 mL	92.0132 mL
	5 mM	0.7361 mL	3.6805 mL	7.3611 mL	18.4026 mL
	10 mM	0.3681 mL	1.8403 mL	3.6805 mL	9.2013 mL
	15 mM	0.2454 mL	1.2268 mL	2.4537 mL	6.1342 mL
	20 mM	0.1840 mL	0.9201 mL	1.8403 mL	4.6007 mL
	25 mM	0.1472 mL	0.7361 mL	1.4722 mL	3.6805 mL
	30 mM	0.1227 mL	0.6134 mL	1.2268 mL	3.0671 mL
	40 mM	0.0920 mL	0.4601 mL	0.9201 mL	2.3003 mL
	50 mM	0.0736 mL	0.3681 mL	0.7361 mL	1.8403 mL
	60 mM	0.0613 mL	0.3067 mL	0.6134 mL	1.5336 mL
	80 mM	0.0460 mL	0.2300 mL	0.4601 mL	1.1502 mL
	100 mM	0.0368 mL	0.1840 mL	0.3681 mL	0.9201 mL

COQ7-IN-1 Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COQ7-IN-12579696-72-1Mitochondrial MetabolismCOQ7UbiquinoneUQCoQsynthesis,Inhibitorinhibitorinhibit

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COQ7-IN-1

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Complete Stock Solution Preparation Table

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