2. Anti-infection Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Fungal IFNAR Reactive Oxygen Species
  4. Cyclo(L-Phe-L-Pro)

Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay.

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Cyclo(L-Phe-L-Pro) Chemical Structure

Cyclo(L-Phe-L-Pro) Chemical Structure

CAS No. : 3705-26-8

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Based on 1 publication(s) in Google Scholar

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Description

Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].

Molecular Weight

244.29

Formula

C14H16N2O2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

Cyclo(FP)
Structure Classification
Initial Source

Human pathogen Vibrio vulnificus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1023.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0935 mL 20.4675 mL 40.9350 mL
5 mM 0.8187 mL 4.0935 mL 8.1870 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0935 mL 20.4675 mL 40.9350 mL 102.3374 mL
5 mM 0.8187 mL 4.0935 mL 8.1870 mL 20.4675 mL
10 mM 0.4093 mL 2.0467 mL 4.0935 mL 10.2337 mL
15 mM 0.2729 mL 1.3645 mL 2.7290 mL 6.8225 mL
20 mM 0.2047 mL 1.0234 mL 2.0467 mL 5.1169 mL
25 mM 0.1637 mL 0.8187 mL 1.6374 mL 4.0935 mL
30 mM 0.1364 mL 0.6822 mL 1.3645 mL 3.4112 mL
40 mM 0.1023 mL 0.5117 mL 1.0234 mL 2.5584 mL
50 mM 0.0819 mL 0.4093 mL 0.8187 mL 2.0467 mL
60 mM 0.0682 mL 0.3411 mL 0.6822 mL 1.7056 mL
80 mM 0.0512 mL 0.2558 mL 0.5117 mL 1.2792 mL
100 mM 0.0409 mL 0.2047 mL 0.4093 mL 1.0234 mL
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Cyclo(L-Phe-L-Pro) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(L-Phe-L-Pro)3705-26-8FungalIFNARReactive Oxygen SpeciesInterferon-α/β receptorInterferon-alpha/beta receptorantifungal cyclic dipeptideIFN-β productionretinoic-acid-inducible gene-IRIG-I activationfree-radical scavenging activityDPPH assayInhibitorinhibitorinhibit

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