Dopamine-d₅ hydrochloride

Name: Dopamine-d 5 hydrochloride
Brand: MedChemExpress
SKU: HY-B0451AS7
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0451AS7 Purity: 99.6%: FAQs
Data Sheet SDS COA Handling Instructions

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Dopamine-d₅ (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body[1]. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

For research use only. We do not sell to patients.

Dopamine-d<sub>5</sub> hydrochloride Chemical Structure

Dopamine-d₅ hydrochloride Chemical Structure

CAS No. : 2193106-55-5

Size	Price	Stock	Quantity
1 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 930	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

194.67

Formula

C₈H₇D₅ClNO₂

CAS No.

2193106-55-5

Unlabeled CAS

62-31-7

Appearance

Solid

Color

White to off-white

SMILES

NCC([2H])([2H])C1=C([2H])C(O)=C(C([2H])=C1[2H])O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (256.84 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1369 mL	25.6845 mL	51.3690 mL
5 mM	1.0274 mL	5.1369 mL	10.2738 mL
10 mM	0.5137 mL	2.5684 mL	5.1369 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.6%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Juárez Olguín H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467. [Content Brief]

[3]. Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.1369 mL	25.6845 mL	51.3690 mL	128.4225 mL
	5 mM	1.0274 mL	5.1369 mL	10.2738 mL	25.6845 mL
	10 mM	0.5137 mL	2.5684 mL	5.1369 mL	12.8422 mL
	15 mM	0.3425 mL	1.7123 mL	3.4246 mL	8.5615 mL
	20 mM	0.2568 mL	1.2842 mL	2.5684 mL	6.4211 mL
	25 mM	0.2055 mL	1.0274 mL	2.0548 mL	5.1369 mL
	30 mM	0.1712 mL	0.8561 mL	1.7123 mL	4.2807 mL
	40 mM	0.1284 mL	0.6421 mL	1.2842 mL	3.2106 mL
	50 mM	0.1027 mL	0.5137 mL	1.0274 mL	2.5684 mL
	60 mM	0.0856 mL	0.4281 mL	0.8561 mL	2.1404 mL
	80 mM	0.0642 mL	0.3211 mL	0.6421 mL	1.6053 mL
	100 mM	0.0514 mL	0.2568 mL	0.5137 mL	1.2842 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.