CDK3 - cyclin dependent kinase 3 Gene

Homo sapiens

Gene ID: 1018 | Gene type: protein coding

About CDK3

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,000,855-76,005,998 (from NCBI)

This gene has 3 transcripts (splice variants), 121 orthologues and 26 paralogues. Ubiquitous expression in skin (RPKM 8.9), small intestine (RPKM 6.9) and 25 other tissues.

Summary

This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

CDK3 Products(1)

mRNA	Protein	Name
NM_001258.4	NP_001249.1	cyclin-dependent kinase 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9840943	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	24550317	GOA
involved in G0 to G1 transition	IDA IDA: Inferred from direct assay	15084261	GOA
involved in negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	25344755	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of cyclin-dependent protein kinase holoenzyme complex	IPI IPI: Inferred from physical interaction	15084261	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK3 Protein Structure

Pkinase

0
100
200
305 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinase 3

cell division protein kinase 3

CDK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CDK3	Q00526	CCNI	Homo sapiens	Q14094	Validated Y2H	32296183
Intra	CDK3	Q00526	CCNI	Homo sapiens	Q14094	Y2H Array	32296183
Intra	CDK3	Q00526	CCNI	Homo sapiens	Q14094	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	CDK3	Q00526	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	CDK3	Q00526	SPDYE4	Homo sapiens	A6NLX3	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	SPDYE4	Homo sapiens	A6NLX3	Y2H Array	32296183
Intra	CDK3	Q00526	a0a384nq31_human	Homo sapiens	A0A384NQ31	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	a0a384nq31_human	Homo sapiens	A0A384NQ31	Y2H Array	32296183
Intra	CDK3	Q00526	OR2G6	Homo sapiens	Q5TZ20	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	OR2G6	Homo sapiens	Q5TZ20	Validated Y2H	32296183
Intra	CDK3	Q00526	OR2G6	Homo sapiens	Q5TZ20	Y2H Array	32296183
Intra	CDK3	Q00526	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	CDK3	Q00526	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CDK3	Q00526	PAX8	Homo sapiens	Q06710	Validated Y2H	32296183
Intra	CDK3	Q00526	PAX8	Homo sapiens	Q06710	Y2H Array	32296183
Intra	CDK3	Q00526	LHX4	Homo sapiens	Q969G2	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	LHX4	Homo sapiens	Q969G2	Validated Y2H	32296183
Intra	CDK3	Q00526	LHX4	Homo sapiens	Q969G2	Y2H Array	32296183
Intra	CDK3	Q00526	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	CDK3	Q00526	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	CDK3	Q00526	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	CDK3	Q00526	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	CDK3	Q00526	CCND3	Homo sapiens	P30281	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	CCND3	Homo sapiens	P30281	Y2H Array	32296183
Intra	CDK3	Q00526	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	33961781
Intra	CDK3	Q00526	CCNE2	Homo sapiens	O96020	Anti Tag CoIP	28514442
Intra	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Y2H Array	32296183
Intra	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	33961781
Intra	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	TAP	23602568
Intra	CDK3	Q00526	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	28514442
Intra	CDK3	Q00526	CCNC	Homo sapiens	P24863	Y2H Array	32296183
Intra	CDK3	Q00526	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	CKS1B	Homo sapiens	P61024	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	CKS1B	Homo sapiens	P61024	TAP	23602568
Intra	CDK3	Q00526	CKS1B	Homo sapiens	P61024	Anti Tag CoIP	33961781
Intra	CDK3	Q00526	CKS1B	Homo sapiens	P61024	Y2H Array	32296183
Intra	CDK3	Q00526	NELFA	Homo sapiens	Q9H3P2	Y2H Array	32296183
Intra	CDK3	Q00526	NELFA	Homo sapiens	Q9H3P2	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	NELFA	Homo sapiens	Q9H3P2	Validated Y2H	32296183
Intra	CDK3	Q00526	CKS2	Homo sapiens	P33552	Anti Tag CoIP	33961781
Intra	CDK3	Q00526	CKS2	Homo sapiens	P33552	Anti Tag CoIP	28514442
Intra	CDK3	Q00526	CKS2	Homo sapiens	P33552	Y2H Array	32296183
Intra	CDK3	Q00526	CKS2	Homo sapiens	P33552	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	RACGAP1	Homo sapiens	Q9H0H5	Y2H Array	32296183
Intra	CDK3	Q00526	RACGAP1	Homo sapiens	Q9H0H5	Validated Y2H	32296183
Intra	CDK3	Q00526	RACGAP1	Homo sapiens	Q9H0H5	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	CCNH	Homo sapiens	P51946	Y2H Array	32296183
Intra	CDK3	Q00526	CCNH	Homo sapiens	P51946	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	CDK3	Q00526	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183
Intra	CDK3	Q00526	FOXP2	Homo sapiens	O15409	Y2H Prey Pooling	32296183
Intra	CDK3	Q00526	FOXP2	Homo sapiens	O15409	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10014	R547	Inhibitor	99.57%	Phase 1
HY-12871B	Atuveciclib	Inhibitor	99.80%	Phase 1
HY-15504	RGB-286638	Inhibitor	99.70%	Phase 1
HY-15504A	RGB-286638 free base	Inhibitor	98.07%	Phase 1
HY-137443	Ipivivint	Inhibitor	99.65%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10329	JNJ-7706621	Inhibitor	99.91%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-15241	NVP-LCQ195	Inhibitor	98.81%	Unkown
HY-N9561	Vanicoside B	Inhibitor	99.82%	Unkown
HY-X0009A	JSH-009 dimaleate	Inhibitor	/	Unkown
HY-163856	CDK7-IN-30	Inhibitor	/	Unkown
HY-142696	CDK6/PIM1-IN-1	Inhibitor	/	Unkown
HY-151878	CDK7-IN-20	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDK3	VGNC	VGNC:107052
Mus musculus	CDK3	MGD	MGI:1916931
Bos taurus	CDK3	VGNC	VGNC:55794
Canis familiaris	CDK3	VGNC	VGNC:51938
Others	CDK3	NCBI

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