2. Gene
  3. CKS1B - CDC28 protein kinase regulatory subunit 1B Gene

CKS1B - CDC28 protein kinase regulatory subunit 1B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CKS1; ckshs1; PNAS-16; PNAS-18

Gene ID: 1163 | Gene type: protein coding

About CKS1B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,974,681-154,979,251 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 29.0), fat (RPKM 22.7) and 24 other tissues.

Summary

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

CKS1B Products(1)

mRNA Protein Name
NM_001826.3 NP_001817.1 cyclin-dependent kinases regulatory subunit 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
2227411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKS1B Protein Structure

CKS

CKS: Cyclin-dependent kinase regulatory subunit (5 - 73)

  • 0
  • 79 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinases regulatory subunit 1

CDC2-associated protein CKS1

CKS1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CKS1B P61024 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
CKS1B P61024 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 CDX4 Homo sapiens O14627
Y2H Array
25416956
Intra
CKS1B P61024 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
CKS1B P61024 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
CKS1B P61024 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
CKS1B P61024 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
CKS1B P61024 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
CKS1B P61024 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
CKS1B P61024 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra
CKS1B P61024 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
CKS1B P61024 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
CKS1B P61024 WASF3 Homo sapiens Q9UPY6-2
Validated Y2H
32296183
Intra
CKS1B P61024 WASF3 Homo sapiens Q9UPY6-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 WASF3 Homo sapiens Q9UPY6-2
Y2H Array
32296183
Intra
CKS1B P61024 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
CKS1B P61024 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
CKS1B P61024 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
CKS1B P61024 CT45A1 Homo sapiens Q5HYN5
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CT45A1 Homo sapiens Q5HYN5
Y2H Array
32296183
Intra
CKS1B P61024 CT45A1 Homo sapiens Q5HYN5
Validated Y2H
32296183
Intra
CKS1B P61024 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
CKS1B P61024 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
CKS1B P61024 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CDK3 Homo sapiens Q00526
Anti Tag CoIP
33961781
Intra
CKS1B P61024 CDK3 Homo sapiens Q00526
Anti Tag CoIP
28514442
Intra
CKS1B P61024 CDK3 Homo sapiens Q00526
Validated Y2H
32296183
Intra
CKS1B P61024 TRIM49C Homo sapiens P0CI26
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TRIM49C Homo sapiens P0CI26
Y2H Array
32296183
Intra
CKS1B P61024 SNRNP35 Homo sapiens Q16560-2
Validated Y2H
32296183
Intra
CKS1B P61024 SNRNP35 Homo sapiens Q16560-2
Y2H Array
32296183
Intra
CKS1B P61024 SNRNP35 Homo sapiens Q16560-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CKS1B P61024 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CKS1B P61024 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra
CKS1B P61024 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 MIPOL1 Homo sapiens Q8TD10
Y2H Array
25416956
Intra
CKS1B P61024 TRIM14 Homo sapiens Q14142
Validated Y2H
32296183
Intra
CKS1B P61024 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
CKS1B P61024 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SERTAD2 Homo sapiens Q14140
Validated Y2H
32296183
Intra
CKS1B P61024 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Array
25416956
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
CKS1B P61024 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PAX5 Homo sapiens Q02548
Validated Y2H
32296183
Intra
CKS1B P61024 CDK2 Homo sapiens P24941
BRET
37398436
Intra
CKS1B P61024 CDK2 Homo sapiens P24941
Anti Tag CoIP
33961781
Intra
CKS1B P61024 CDK2 Homo sapiens P24941
Anti Tag CoIP
28514442
Intra
CKS1B P61024 CCNC Homo sapiens P24863
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CCNC Homo sapiens P24863
Y2H Array
32296183
Intra
CKS1B P61024 ZBTB9 Homo sapiens Q96C00
Validated Y2H
32296183
Intra
CKS1B P61024 ZBTB9 Homo sapiens Q96C00
Y2H Array
32296183
Intra
CKS1B P61024 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MED12L Homo sapiens Q86YW9
Y2H Array
32296183
Intra
CKS1B P61024 MED12L Homo sapiens Q86YW9
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MED12L Homo sapiens Q86YW9
Validated Y2H
32296183
Intra
CKS1B P61024 CDK1 Homo sapiens P06493
Anti Tag CoIP
33961781
Intra
CKS1B P61024 CDK1 Homo sapiens P06493
Anti Tag CoIP
28514442
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
Anti Tag CoIP
33961781
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
X-Ray Diffraction
16209941
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
Anti Tag CoIP
28514442
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
Pull Down
12813041
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
ITC
16209941
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Validated Y2H
32296183
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Array
32296183
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Array
31515488
Intra
CKS1B P61024 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
CKS1B P61024 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
CKS1B P61024 TRIM49 Homo sapiens P0CI25
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TRIM49 Homo sapiens P0CI25
Y2H Array
32296183
Intra
CKS1B P61024 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CKS1B P61024 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
CKS1B P61024 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
CKS1B P61024 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
CKS1B P61024 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
25416956
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Y2H Array
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
CKS1B P61024 CCDC120 Homo sapiens Q96HB5
Y2H Array
32296183
Intra
CKS1B P61024 CCDC120 Homo sapiens Q96HB5
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
CKS1B P61024 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
CKS1B P61024 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
CKS1B P61024 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra
CKS1B P61024 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 NR5A1 Homo sapiens Q13285
Y2H Array
32296183
Intra
CKS1B P61024 NR5A1 Homo sapiens Q13285
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 NR5A1 Homo sapiens Q13285
Validated Y2H
32296183
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Validated Y2H
32296183
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Clear Cell Adenofibroma

Cystadenofibroma
Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance

Mgus

Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

Monoclonal Gammopathy Nos

Iga Gammopathy

Monoclonal Gammoglobulinopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02742 CKS1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CKS1B RGD RGD:1561797
Bos taurus CKS1B VGNC VGNC:27387
Mus musculus CKS1B MGD MGI:1889208
Macaca mulatta CKS1B VGNC VGNC:106341
Others CKS1B NCBI