2. Gene
  3. BTN2A2 - butyrophilin subfamily 2 member A2 Gene

BTN2A2 - butyrophilin subfamily 2 member A2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as BTF2; BT2.2; BTN2.2

Gene ID: 10385 | Gene type: protein coding

About BTN2A2

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,383,108-26,394,874 (from NCBI)

This gene has 16 transcripts (splice variants), 110 orthologues and 15 paralogues. Broad expression in lymph node (RPKM 8.9), appendix (RPKM 6.5) and 24 other tissues.

Summary

Butyrophilin is the major protein associated with fat droplets in the milk. This gene is a member of the BTN2 subfamily of genes, which encode proteins belonging to the butyrophilin protein family. The gene is located in a cluster on chromosome 6, consisting of seven genes belonging to the expanding B7/butyrophilin-like group, a subset of the immunoglobulin gene superfamily. The encoded protein is a type I receptor glycoprotein involved in lipid, fatty-acid and sterol metabolism. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

BTN2A2 Products(6)

mRNA Protein Name
NM_001197237.2 NP_001184166.1 butyrophilin subfamily 2 member A2 isoform a precursor
NM_001197238.2 NP_001184167.1 butyrophilin subfamily 2 member A2 isoform c precursor
NM_001197239.2 NP_001184168.1 butyrophilin subfamily 2 member A2 isoform d precursor
NM_001197240.2 NP_001184169.1 butyrophilin subfamily 2 member A2 isoform e precursor
NM_006995.5 NP_008926.2 butyrophilin subfamily 2 member A2 isoform a precursor
NM_181531.3 NP_853509.1 butyrophilin subfamily 2 member A2 isoform b precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTN2A2 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (35 - 133)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (160 - 233)

PRY

PRY: SPRY-associated domain (329 - 377)

SPRY

SPRY: SPRY domain (379 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 523 a.a.
Protein Preferred Names Protein Names

butyrophilin subfamily 2 member A2

butyrophilin 2

BTN2A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra BTN2A2 Q8WVV5 MRM3 Homo sapiens Q9HC36
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 MRM3 Homo sapiens Q9HC36
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 MRM3 Homo sapiens Q9HC36
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMEM179B Homo sapiens Q7Z7N9
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMEM179B Homo sapiens Q7Z7N9
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SPNS3 Homo sapiens Q6ZMD2-2
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 SPNS3 Homo sapiens Q6ZMD2-2
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SLC14A1 Homo sapiens Q13336-2
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SLC14A1 Homo sapiens Q13336-2
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 PSMA3 Homo sapiens P25788
Y2H Prey Pooling
25416956
Intra BTN2A2 Q8WVV5 PSMA3 Homo sapiens P25788
Y2H Array
25416956
Intra BTN2A2 Q8WVV5 SLC1A3 Homo sapiens P43003
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 SLC1A3 Homo sapiens P43003
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 GJB3 Homo sapiens O75712
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 GJB3 Homo sapiens O75712
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 HSD3B7 Homo sapiens Q9H2F3
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 HSD3B7 Homo sapiens Q9H2F3
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 EMP1 Homo sapiens P54849
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 SYT1 Homo sapiens P21579
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 SYT1 Homo sapiens P21579
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra BTN2A2 Q8WVV5 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra BTN2A2 Q8WVV5 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra BTN2A2 Q8WVV5 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra BTN2A2 Q8WVV5 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra BTN2A2 Q8WVV5 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra BTN2A2 Q8WVV5 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTN2A2 Proteins

Cat. No. Product Name Accession Purity
HY-P7682 BTN2A2 Protein, Human (HEK293, Fc) Q8WVV5 (Q33-V237) ≥95%
HY-P72344 BTN2A2 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q8WVV5 (Q33-V237) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01672 BTN2A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BTN2A2 MGD MGI:3606486
Rattus norvegicus BTN2A2 RGD RGD:1306973
Others BTN2A2 NCBI