2. Gene
  3. PGRMC1 - progesterone receptor membrane component 1 Gene

PGRMC1 - progesterone receptor membrane component 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IZA; MPR; Dap1; HPR6.6

Gene ID: 10857 | Gene type: protein coding

About PGRMC1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,236,285-119,244,466 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues.

Summary

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

PGRMC1 Products(2)

mRNA Protein Name
NM_001282621.2 NP_001269550.1 membrane-associated progesterone receptor component 1 isoform 2
NM_006667.5 NP_006658.1 membrane-associated progesterone receptor component 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables heme binding IDA
IDA: Inferred from direct assay
26988023 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21081644 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
26988023 GOA
Biological Process GO Annotation Evidence Reference Source
involved in heme biosynthetic process IDA
IDA: Inferred from direct assay
27599036 GOA
involved in positive regulation of lipoprotein transport IMP
IMP: Inferred from mutant phenotype
30443021 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
25390692 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGRMC1 Protein Structure

Cyt-b5

Cyt-b5: Cytochrome b5-like Heme/Steroid binding domain (73 - 170)

  • 0
  • 100
  • 195 a.a.
Protein Preferred Names Protein Names

membrane-associated progesterone receptor component 1

progesterone binding protein

PGRMC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Anti Tag CoIP
35271311
Intra
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Validated Y2H
32296183
Intra
PGRMC1 O00264 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
PGRMC1 O00264 KCNE5 Homo sapiens Q9UJ90
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 KCNE5 Homo sapiens Q9UJ90
Validated Y2H
32296183
Intra
PGRMC1 O00264 KCNE5 Homo sapiens Q9UJ90
Y2H Array
32296183
Intra
PGRMC1 O00264 DEFB124 Homo sapiens Q8NES8
Validated Y2H
32296183
Intra
PGRMC1 O00264 DEFB124 Homo sapiens Q8NES8
Y2H Array
32296183
Intra
PGRMC1 O00264 DEFB124 Homo sapiens Q8NES8
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 CAMLG Homo sapiens P49069
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 CAMLG Homo sapiens P49069
Validated Y2H
32296183
Intra
PGRMC1 O00264 CAMLG Homo sapiens P49069
Y2H Array
32296183
Intra
PGRMC1 O00264 EVI2B Homo sapiens P34910-2
Validated Y2H
32296183
Intra
PGRMC1 O00264 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
PGRMC1 O00264 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 GET3 Homo sapiens O43681
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 GET3 Homo sapiens O43681
Validated Y2H
32296183
Intra
PGRMC1 O00264 GET3 Homo sapiens O43681
Y2H Array
32296183
Intra
PGRMC1 O00264 DHCR24 Homo sapiens Q15392
Anti Tag CoIP
35271311
Intra
PGRMC1 O00264 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
PGRMC1 O00264 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
PGRMC1 O00264 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra
PGRMC1 O00264 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
PGRMC1 O00264 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 ZNF71 Homo sapiens Q9NQZ8
Y2H Array
32296183
Intra
PGRMC1 O00264 ZNF71 Homo sapiens Q9NQZ8
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 ZNF71 Homo sapiens Q9NQZ8
Validated Y2H
32296183
Intra
PGRMC1 O00264 CIAO1 Homo sapiens O76071
Validated Y2H
32296183
Intra
PGRMC1 O00264 CIAO1 Homo sapiens O76071
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 CIAO1 Homo sapiens O76071
Y2H Array
32296183
Intra
PGRMC1 O00264 POR Homo sapiens P16435
Anti Tag CoIP
21081644
Intra
PGRMC1 O00264 POR Homo sapiens P16435
Anti Tag CoIP
35271311
Intra
PGRMC1 O00264 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
PGRMC1 O00264 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
PGRMC1 O00264 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
PGRMC1 O00264 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra
PGRMC1 O00264 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
PGRMC1 O00264 CCDC134 Homo sapiens Q9H6E4
Validated Y2H
32296183
Intra
PGRMC1 O00264 CCDC134 Homo sapiens Q9H6E4
Y2H Array
32296183
Intra
PGRMC1 O00264 CCDC134 Homo sapiens Q9H6E4
Y2H Prey Pooling
32296183
Cross
PGRMC1 O00264 CYP2C2 Oryctolagus cuniculus P00181
Confocal
21081644
Cross
PGRMC1 O00264 CYP2C2 Oryctolagus cuniculus P00181
Anti Tag CoIP
21081644
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cataract 44

CTRCT44

Total Early-Onset Cataract

Cataract 44 And Hypotrichosis

Cataract And Hypotrichosis

Cataract, Type 44
Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor

Extragonadal Germ Cell Malignant Tumor

Neoplasm Of Extragonadal Germ Cell

Tumor Of Extragonadal Germ Cell
Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes

PPROM

Preterm Premature Rupture Of The Membranes, Susceptibility To

Pprom - [Preterm Premature Rupture Of Membranes]

Preterm Rupture Of Membranes
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C

NPC1

Niemann-Pick Disease, Type D

Niemann-Pick Disease Type C1

Niemann-Pick Disease With Cholesterol Esterification Block

Niemann-Pick Disease, Subacute Juvenile Form

Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

Npc

Niemann-Pick Disease, Chronic Neuronopathic Form

Niemann-Pick Disease Without Sphingomyelinase Deficiency

Niemann-Pick Disease Type C

Niemann-Pick Disease Type D

Niemann-Pick C1 Disease

Niemann-Pick Disease C1

Niemann-Pick Disease Chronic Neuronopathic Form

Niemann-Pick Disease Nova Scotian Type

Niemann-Pick Disease Subacute Juvenile Form

Niemann-Pick Disease Type Ii

Niemann-Picks Disease Type C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115625 AG-205 / Unkown
HY-121012 (rac)-AG-205 / Unkown
HY-RS10399 PGRMC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PGRMC1 VGNC VGNC:75806
Canis familiaris PGRMC1 VGNC VGNC:44470
Mus musculus PGRMC1 MGD MGI:1858305
Rattus norvegicus PGRMC1 RGD RGD:70890
Bos taurus PGRMC1 VGNC VGNC:32801