PGRMC1 - progesterone receptor membrane component 1 Gene

Homo sapiens

Also known as IZA; MPR; Dap1; HPR6.6

Gene ID: 10857 | Gene type: protein coding

About PGRMC1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,236,285-119,244,466 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 180.6), kidney (RPKM 113.3) and 24 other tissues.

Summary

This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]

PGRMC1 Products(2)

mRNA	Protein	Name
NM_001282621.2	NP_001269550.1	membrane-associated progesterone receptor component 1 isoform 2
NM_006667.5	NP_006658.1	membrane-associated progesterone receptor component 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables heme binding	IDA IDA: Inferred from direct assay	26988023	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21081644	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	26988023	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in heme biosynthetic process	IDA IDA: Inferred from direct assay	27599036	GOA
involved in positive regulation of lipoprotein transport	IMP IMP: Inferred from mutant phenotype	30443021	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	25390692	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PGRMC1 Protein Structure

Cyt-b5

0
100
195 a.a.

Protein Preferred Names

Protein Names

membrane-associated progesterone receptor component 1

progesterone binding protein

Related Diseases

Diseases

Alias

Cataract 44

CTRCT44	Total Early-Onset Cataract
Cataract 44 And Hypotrichosis	Cataract And Hypotrichosis
Cataract, Type 44

Extragonadal Germ Cell Cancer

Extragonadal Germ Cell Tumor	Extragonadal Germ Cell Malignant Tumor
Neoplasm Of Extragonadal Germ Cell	Tumor Of Extragonadal Germ Cell

Preterm Premature Rupture Of The Membranes

Preterm Premature Rupture Of Membranes	PPROM
Preterm Premature Rupture Of The Membranes, Susceptibility To	Pprom - [Preterm Premature Rupture Of Membranes]
Preterm Rupture Of Membranes

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C	NPC1
Niemann-Pick Disease, Type D	Niemann-Pick Disease Type C1
Niemann-Pick Disease With Cholesterol Esterification Block	Niemann-Pick Disease, Subacute Juvenile Form
Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia	Npc
Niemann-Pick Disease, Chronic Neuronopathic Form	Niemann-Pick Disease Without Sphingomyelinase Deficiency
Niemann-Pick Disease Type C	Niemann-Pick Disease Type D
Niemann-Pick C1 Disease	Niemann-Pick Disease C1
Niemann-Pick Disease Chronic Neuronopathic Form	Niemann-Pick Disease Nova Scotian Type
Niemann-Pick Disease Subacute Juvenile Form	Niemann-Pick Disease Type Ii
Niemann-Picks Disease Type C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115625	AG-205		/	Unkown
HY-121012	(rac)-AG-205		/	Unkown
HY-RS10399	PGRMC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PGRMC1	VGNC	VGNC:75806
Canis familiaris	PGRMC1	VGNC	VGNC:44470
Mus musculus	PGRMC1	MGD	MGI:1858305
Rattus norvegicus	PGRMC1	RGD	RGD:70890
Bos taurus	PGRMC1	VGNC	VGNC:32801

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