GADD45G - growth arrest and DNA damage inducible gamma Gene

Homo sapiens

Also known as CR6; DDIT2; GRP17; GADD45gamma

Gene ID: 10912 | Gene type: protein coding

About GADD45G

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,605,012-89,606,555 (from NCBI)

This gene has 3 transcripts (splice variants), 343 orthologues and 2 paralogues. Broad expression in liver (RPKM 21.4), placenta (RPKM 16.8) and 22 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

GADD45G Products(1)

mRNA	Protein	Name
NM_006705.4	NP_006696.1	growth arrest and DNA damage-inducible protein GADD45 gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12052864	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	9827804	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	9827804	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9827804	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9827804	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GADD45G Protein Structure

Ribosomal_L7Ae

0
100
159 a.a.

Protein Preferred Names

Protein Names

growth arrest and DNA damage-inducible protein GADD45 gamma

DDIT-2

GADD45G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GADD45G	O95257	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	GADD45G	O95257	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	GADD45G	O95257	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	GADD45G	O95257	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Prey Pooling	25416956
Intra	GADD45G	O95257	ZNF763	Homo sapiens	Q0D2J5	Validated Y2H	32296183
Intra	GADD45G	O95257	ZNF763	Homo sapiens	Q0D2J5	Y2H Array	32296183
Intra	GADD45G	O95257	ZNF763	Homo sapiens	Q0D2J5	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	AFAP1L1	Homo sapiens	Q8TED9	Y2H Prey Pooling	25416956
Intra	GADD45G	O95257	AFAP1L1	Homo sapiens	Q8TED9	Y2H Array	25416956
Intra	GADD45G	O95257	AFAP1L1	Homo sapiens	Q8TED9	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	AFAP1L1	Homo sapiens	Q8TED9	Y2H Array	31515488
Intra	GADD45G	O95257	AFAP1L1	Homo sapiens	Q8TED9	Validated Y2H	32296183
Intra	GADD45G	O95257	AFAP1L1	Homo sapiens	Q8TED9	Y2H Array	32296183
Intra	GADD45G	O95257	GRAMD4	Homo sapiens	Q6IC98	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	GRAMD4	Homo sapiens	Q6IC98	Y2H Array	32296183
Intra	GADD45G	O95257	GRAMD4	Homo sapiens	Q6IC98	Validated Y2H	32296183
Intra	GADD45G	O95257	NMB	Homo sapiens	P08949-2	Validated Y2H	32296183
Intra	GADD45G	O95257	NMB	Homo sapiens	P08949-2	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	NMB	Homo sapiens	P08949-2	Y2H Array	32296183
Intra	GADD45G	O95257	CFAP44	Homo sapiens	Q96MT7	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	CFAP44	Homo sapiens	Q96MT7	Y2H Array	32296183
Intra	GADD45G	O95257	CNOT9	Homo sapiens	Q92600-3	Validated Y2H	32296183
Intra	GADD45G	O95257	CNOT9	Homo sapiens	Q92600-3	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	CNOT9	Homo sapiens	Q92600-3	Y2H Array	32296183
Intra	GADD45G	O95257	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	GADD45G	O95257	TSNAX	Homo sapiens	Q99598	Y2H Array	32296183
Intra	GADD45G	O95257	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	ZNF664	Homo sapiens	Q8N3J9	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	ZNF664	Homo sapiens	Q8N3J9	Validated Y2H	32296183
Intra	GADD45G	O95257	ZNF664	Homo sapiens	Q8N3J9	Y2H Array	32296183
Intra	GADD45G	O95257	ACTN1	Homo sapiens	P12814	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	ACTN1	Homo sapiens	P12814	Y2H Array	32296183
Intra	GADD45G	O95257	ACTN1	Homo sapiens	P12814	Validated Y2H	32296183
Intra	GADD45G	O95257	GADD45GIP1	Homo sapiens	Q8TAE8	Anti Tag CoIP	12716909
Intra	GADD45G	O95257	GADD45GIP1	Homo sapiens	Q8TAE8	Y2H	12716909
Intra	GADD45G	O95257	MED31	Homo sapiens	Q9Y3C7	Y2H	15383276
Intra	GADD45G	O95257	KAT5	Homo sapiens	Q92993	Pull Down	15383276
Intra	GADD45G	O95257	MAP3K4	Homo sapiens	Q9Y6R4	DHFR Reconstruction	12052864
Intra	GADD45G	O95257	MAP3K4	Homo sapiens	Q9Y6R4	Anti Tag CoIP	33961781
Intra	GADD45G	O95257	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	GADD45G	O95257	BLOC1S2	Homo sapiens	Q6QNY1	Validated Y2H	32296183
Intra	GADD45G	O95257	CEP126	Homo sapiens	Q9P2H0	Y2H	15383276
Intra	GADD45G	O95257	CEP126	Homo sapiens	Q9P2H0	Pull Down	15383276
Intra	GADD45G	O95257	LRIF1	Homo sapiens	Q5T3J3	Validated Y2H	32296183
Intra	GADD45G	O95257	LRIF1	Homo sapiens	Q5T3J3	Y2H	15383276
Intra	GADD45G	O95257	LRIF1	Homo sapiens	Q5T3J3	Y2H Array	32296183
Intra	GADD45G	O95257	LRIF1	Homo sapiens	Q5T3J3	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	UTP14A	Homo sapiens	Q9BVJ6	Pull Down	15383276
Intra	GADD45G	O95257	RASSF10	Homo sapiens	A6NK89	Y2H Array	32296183
Intra	GADD45G	O95257	RASSF10	Homo sapiens	A6NK89	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	ARPC5L	Homo sapiens	Q9BPX5	Y2H	21988832
Intra	GADD45G	O95257	ARPC5L	Homo sapiens	Q9BPX5	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	ARPC5L	Homo sapiens	Q9BPX5	Validated Y2H	32296183
Intra	GADD45G	O95257	ARPC5L	Homo sapiens	Q9BPX5	Y2H Array	32296183
Intra	GADD45G	O95257	DCTN2	Homo sapiens	Q13561	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	DCTN2	Homo sapiens	Q13561	Validated Y2H	32296183
Intra	GADD45G	O95257	DCTN2	Homo sapiens	Q13561	Y2H Array	32296183
Intra	GADD45G	O95257	RRP7A	Homo sapiens	Q9Y3A4	Y2H Array	32296183
Intra	GADD45G	O95257	RRP7A	Homo sapiens	Q9Y3A4	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	RRP7A	Homo sapiens	Q9Y3A4	Validated Y2H	32296183
Intra	GADD45G	O95257	RWDD2B	Homo sapiens	P57060	Validated Y2H	32296183
Intra	GADD45G	O95257	RWDD2B	Homo sapiens	P57060	Y2H Array	32296183
Intra	GADD45G	O95257	RWDD2B	Homo sapiens	P57060	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	RWDD2B	Homo sapiens	P57060	Validated Y2H	25416956
Intra	GADD45G	O95257	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	GADD45G	O95257	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	GADD45G	O95257	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	GADD45G	O95257	ENKD1	Homo sapiens	Q9H0I2	Y2H Array	32296183
Intra	GADD45G	O95257	ENKD1	Homo sapiens	Q9H0I2	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	FAM156B	Homo sapiens	Q8NDB6	Validated Y2H	32296183
Intra	GADD45G	O95257	FAM156B	Homo sapiens	Q8NDB6	Y2H Array	32296183
Intra	GADD45G	O95257	FAM156B	Homo sapiens	Q8NDB6	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	RCN1	Homo sapiens	Q15293	Y2H Array	32296183
Intra	GADD45G	O95257	RCN1	Homo sapiens	Q15293	Y2H Prey Pooling	32296183
Intra	GADD45G	O95257	RCN1	Homo sapiens	Q15293	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GADD45G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70218	GADD45G/DDIT2 Protein, Human (His)	O95257 (M1-E159)	≥95%

Related Diseases

Diseases

Alias

Pituitary Adenoma

Adenoma Of The Pituitary Gland	Pituitary Adenomas
Adenoma, Pituitary	Pituitary Gland Adenoma
Pituitary Neoplasms

Retinal Microaneurysm

Microaneurysm

Severe Nonproliferative Diabetic Retinopathy

High Risk Non Proliferative Diabetic Retinopathy

Severe Npdr

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Background Diabetic Retinopathy

Non Proliferative Diabetic Retinopathy	Non-Proliferative Diabetic Retinopathy
Nonproliferative Diabetic Retinopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05231	GADD45G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GADD45G	VGNC	VGNC:103268
Bos taurus	GADD45G	VGNC	VGNC:29208
Felis catus	GADD45G	VGNC	VGNC:102932
Canis familiaris	GADD45G	VGNC	VGNC:41071
Rattus norvegicus	GADD45G	RGD	RGD:1311796
Mus musculus	GADD45G	MGD	MGI:1346325
Others	GADD45G	NCBI

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