GADD45G - growth arrest and DNA damage inducible gamma Gene

Homo sapiens

Also known as CR6; DDIT2; GRP17; GADD45gamma

Gene ID: 10912 | Gene type: protein coding

About GADD45G

Cytogenetic location: 9q22.2 Genomic coordinates (GRCh38): 9:89,605,012-89,606,555 (from NCBI)

This gene has 3 transcripts (splice variants), 343 orthologues and 2 paralogues. Broad expression in liver (RPKM 21.4), placenta (RPKM 16.8) and 22 other tissues.

Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

GADD45G Products(1)

mRNA	Protein	Name
NM_006705.4	NP_006696.1	growth arrest and DNA damage-inducible protein GADD45 gamma

GADD45G Protein Structure

Ribosomal_L7Ae

0
100
159 a.a.

Protein Preferred Names

Protein Names

growth arrest and DNA damage-inducible protein GADD45 gamma

DDIT-2

Recombinant GADD45G Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70218	GADD45G/DDIT2 Protein, Human (His)	O95257 (M1-E159)	≥95%

Related Diseases

Diseases

Alias

Pituitary Adenoma

Adenoma Of The Pituitary Gland	Pituitary Adenomas
Adenoma, Pituitary	Pituitary Gland Adenoma
Pituitary Neoplasms

Retinal Microaneurysm

Microaneurysm

Severe Nonproliferative Diabetic Retinopathy

High Risk Non Proliferative Diabetic Retinopathy

Severe Npdr

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Background Diabetic Retinopathy

Non Proliferative Diabetic Retinopathy	Non-Proliferative Diabetic Retinopathy
Nonproliferative Diabetic Retinopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05231	GADD45G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GADD45G	VGNC	VGNC:103268
Bos taurus	GADD45G	VGNC	VGNC:29208
Felis catus	GADD45G	VGNC	VGNC:102932
Canis familiaris	GADD45G	VGNC	VGNC:41071
Rattus norvegicus	GADD45G	RGD	RGD:1311796
Mus musculus	GADD45G	MGD	MGI:1346325
Others	GADD45G	NCBI

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