2. Gene
  3. Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Uae1

Gene ID: 114711 | Gene type: protein coding

About Gne

Summary

Enables N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in GNE myopathy and sialuria. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gne Products(1)

mRNA Protein Name
NM_053765.3 NP_446217.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N-acylmannosamine kinase activity IDA
IDA: Inferred from direct assay
9305887 RGD
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
IDA: Inferred from direct assay
9305887 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17118363 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
9305887 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UDP-GlcNAc-2-epimerase/ManAc kinase

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase

Gne Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Gne O35826 ZBTB16 Homo sapiens Q05516
Y2H
17118363
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13246 Apitolisib 99.29% Phase 2
HY-128850 N-Acetyl-D-mannosamine ≥98.0% Phase 2
Pre-clinical Phase
Bioactive Molecules (73)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.73% Unkown
HY-147214 GNE-7883 Inhibitor 98.49% Unkown
HY-108696 GNE-781 Inhibitor 98.16% Unkown
HY-100343 GNE-495 Inhibitor 99.40% Unkown
HY-107986 GNE-6776 Inhibitor 98.01% Unkown
HY-15796 GNE0877 Inhibitor 99.81% Unkown
HY-108435 GNE-049 Inhibitor 99.40% Unkown
HY-12947 GNE-3511 Inhibitor 99.07% Unkown
HY-12632 GNE 2861 Inhibitor 99.20% Unkown
HY-112937 GNE-6640 Inhibitor 99.91% Unkown
HY-129939 PROTAC BRD4 ligand-1 Inhibitor 99.85% Unkown
HY-18163 GNE-7915 Inhibitor 99.82% Unkown
HY-15766 GNE-617 Inhibitor 99.69% Unkown
HY-100742 GNE-140 racemate Inhibitor 99.38% Unkown
HY-129937A GNE-987 Inhibitor 99.91% Unkown
HY-135892 GNE-1858 Inhibitor 99.42% Unkown
HY-120028 GNE-207 Inhibitor 97.02% Unkown
HY-100726 GNE-272 Inhibitor 99.76% Unkown
HY-149026 GNE-064 Inhibitor 99.75% Unkown
HY-154984 JET-209 Degrader 98.07% Unkown
HY-145341 GNE-149 Antagonist 99.66% Unkown
HY-107409 GNE 5729 Agonist 99.50% Unkown
HY-12763 GNE-317 Inhibitor 99.14% Unkown
HY-123621 GNE-375 Inhibitor 99.81% Unkown
HY-133736 PROTAC BRD4 Degrader-5-CO-PEG3-N3 99.73% Unkown
HY-112803 GNE-371 98.21% Unkown
HY-12628 GNE-618 Inhibitor 99.89% Unkown
HY-10811 GNE-493 Inhibitor 99.81% Unkown
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% Unkown
HY-158113 CBPD-409 Degrader / Unkown
HY-114332 GNE-8505 Inhibitor 99.86% Unkown
HY-11042 GNE-477 Inhibitor 98.75% Unkown
HY-19775 GNE-6468 Antagonist 98.04% Unkown
HY-141551 GNE-274 Degrader 98.93% Unkown
HY-15883 GNE-900 99.21% Unkown
HY-12282 GNE-9605 Inhibitor 99.72% Unkown
HY-129938 PROTAC BRD4 Degrader-24 99.61% Unkown
HY-142160 GNE-9815 Inhibitor 98.28% Unkown
HY-19774 GNE-0946 Inhibitor 98.09% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.07% Unkown
HY-123824 GNE-0439 Inhibitor 99.80% Unkown
HY-12410 GNE-9822 Inhibitor ≥95.0% Unkown
HY-129527 GNE-9278 Modulator 99.91% Unkown
HY-149056 GNE-6893 Inhibitor 99.94% Unkown
HY-150289 GNE-235 98.45% Unkown
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% Unkown
HY-108337 GNE-0723 Agonist 98.74% Unkown
HY-117865 GNE-886 Inhibitor 99.81% Unkown
HY-112279 GNE-131 Inhibitor 98.15% Unkown
HY-107498 GNE-8324 Modulator 98.88% Unkown
HY-149056A (3S,4R)-GNE-6893 Inhibitor 99.49% Unkown
HY-RS05551 GNE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-18163A GNE-7915 tosylate Inhibitor 99.69% Unkown
HY-U00428 GNE 220 Inhibitor / Unkown
HY-10812 GNE-490 Inhibitor 96.29% Unkown
HY-126291 GNE-616 Inhibitor / Unkown
HY-132294 GNE-502 Inhibitor 99.73% Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-128585 GNE684 Inhibitor / Unkown
HY-134592 Piperidine-GNE-049-N-Boc 98.82% Unkown
HY-107409B (S,S)-GNE 5729 99.65% Unkown
HY-107423 GNE 6901 Agonist / Unkown
HY-124153 GNE-431 Inhibitor / Unkown
HY-129937 (S)-GNE-987 Inhibitor / Unkown
HY-132294A (1S,3R)-GNE-502 Inhibitor / Unkown
HY-13847 GNE-555 Inhibitor / Unkown
HY-141551B (R)-GNE-274 / Unkown
HY-148238 GNE-2256 Inhibitor / Unkown
HY-162553 GNE7599 / Unkown
HY-16983 GNE-3500 Antagonist / Unkown
HY-16984 GNE-4997 Inhibitor / Unkown
HY-12517 GNE-293 Inhibitor / Unkown
HY-15882 GNE-783 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gne NCBI NCBI:10020